ANKRD55 and PTK6

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		ANKRD55	PTK6
Name		ankyrin repeat domain 55	protein tyrosine kinase 6
Structure		No pdb structure
GO Annotations	Cellular Component	None	Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Body Cell Projection
	Molecular Function	Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding
	Biological Process	None	Protein Phosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Neuron Projection Development Cell Migration Cell Differentiation ERBB2 Signaling Pathway Positive Regulation Of DNA Replication Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Cycle Negative Regulation Of Growth Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Autophosphorylation Intestinal Epithelial Cell Differentiation Negative Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Retinoic Acid
Pathways		None	SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1 ERBB2 Activates PTK6 Signaling PTK6 Regulates Proteins Involved in RNA Processing PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 PTK6 Regulates Cell Cycle PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases PTK6 Down-Regulation PTK6 Expression PTK6 Activates STAT3 PTK6 promotes HIF1A stabilization Cytoprotection by HMOX1
Drugs		None	Vandetanib Tivozanib Fostamatinib Zanubrutinib
GWAS		Alanine aminotransferase levels ( 33547301 ) Alzheimer's disease (cognitive decline) ( 23535033 ) Celiac disease or Rheumatoid arthritis ( 21383967 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 28067908 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) IgA levels ( 28628107 ) IgG glycosylation ( 23382691 ) Immature fraction of reticulocytes ( 32888494 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Lung function (FEV1) ( 30061609 ) Macular thickness ( 30535121 ) Monocyte count ( 32888494 27863252 ) Monocyte percentage of white cells ( 32888494 ) Multiple sclerosis ( 24076602 27386562 31604244 ) Optic disc size ( 31809533 ) Pediatric autoimmune diseases ( 26301688 ) Post-traumatic stress disorder ( 27167565 ) Reticulocyte fraction of red cells ( 32888494 ) Rheumatoid arthritis ( 24390342 23143596 30572963 30423114 ) Rheumatoid arthritis (ACPA-negative) ( 23143596 ) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596 ) Sero-negative rheumatoid arthritis ( 28706201 ) Serum alkaline phosphatase levels ( 33547301 ) Triglycerides ( 20686565 ) Type 1 diabetes ( 34127860 ) Type 2 diabetes ( 29358691 22885922 26818947 26961502 27189021 32499647 30718926 30297969 28869590 ) Urate levels ( 23263486 ) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993 ) Vertical cup-disc ratio (multi-trait analysis) ( 31959993 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500 ) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500 ) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 ) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412 )	Autism spectrum disorder or schizophrenia ( 28540026 ) Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Hair shape ( 29220522 ) Prostate cancer ( 23535732 )
Novel Interactors		2 novel interactors: SETD9 SNX18	None recorded
Interacting Genes		22 interacting genes: ABI2 ANKS1A BACH2 BANP BOLA2 BOLA2B CABP5 CFAP206 CLIC3 FHL2 FHL5 FRS3 HGS HSF2BP NCK2 NOXA1 PFDN5 PTK6 TEKT4 TRIM23 ZMYND19 ZSCAN1	35 interacting genes: ACTN3 ANKRD55 APP AR CBLB CCDC33 DDX17 DOK1 DTX3 EFHC2 EGFR ERBB2 ERBB3 ERBB4 EXOC5 FCHO1 FGFR1 GAB1 HIF1A KHDRBS1 KHDRBS2 KIAA1217 KIT LINC01139 MEIS2 MET MKRN3 MYOZ3 PITX1 PRDM6 REL SLA STAP2 WASL ZNF341
Entrez ID		79722	5753
HPRD ID		07758	03594
Ensembl ID		ENSG00000164512	ENSG00000101213
Uniprot IDs		Q3KP44	Q13882
PDB IDs		Not available	1RJA 2KGT 5D7V 5DA3 5H2U 6CZ2 6CZ3 6CZ4 8S1C
GO Terms Enriched among Interactors		Cytoplasm Iron-sulfur Cluster Assembly Complex [2Fe-2S] Cluster Assembly	Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Complex Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Epithelial Cell Proliferation ERBB2 Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Basal Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway ERBB Signaling Pathway SH2 Domain Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway ERBB3:ERBB2 Complex Visual Learning Regulation Of MAPK Cascade Positive Regulation Of Metabolic Process Visual Behavior Positive Regulation Of Macromolecule Metabolic Process Regulation Of Epithelial Cell Proliferation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Regulation Of Phosphorus Metabolic Process Regulation Of Intracellular Signal Transduction Anatomical Structure Morphogenesis Regulation Of MiRNA Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Regulation Of Growth Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signal Transduction Positive Regulation Of RNA Metabolic Process Regulation Of MiRNA Metabolic Process Regulation Of RNA Metabolic Process Response To Growth Factor ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Regulation Of DNA-templated Transcription Associative Learning Regulation Of RNA Biosynthetic Process Protein Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Population Proliferation