| Name |
ankyrin repeat domain 55 |
chloride intracellular channel 3 |
| Structure |
No pdb structure
|
|
| GO Annotations |
Cellular Component |
None
|
|
| Molecular Function |
|
|
| Biological Process |
None
|
|
| GWAS |
- Alanine aminotransferase levels ( 33547301
)
- Alzheimer's disease (cognitive decline) ( 23535033
)
- Celiac disease or Rheumatoid arthritis ( 21383967
)
- Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007
)
- Crohn's disease ( 28067908
)
- High light scatter reticulocyte count ( 32888494
)
- High light scatter reticulocyte percentage of red cells ( 32888494
)
- IgA levels ( 28628107
)
- IgG glycosylation ( 23382691
)
- Immature fraction of reticulocytes ( 32888494
)
- Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761
)
- Lung function (FEV1) ( 30061609
)
- Macular thickness ( 30535121
)
- Monocyte count ( 32888494
27863252
)
- Monocyte percentage of white cells ( 32888494
)
- Multiple sclerosis ( 24076602
27386562
31604244
)
- Optic disc size ( 31809533
)
- Pediatric autoimmune diseases ( 26301688
)
- Post-traumatic stress disorder ( 27167565
)
- Reticulocyte fraction of red cells ( 32888494
)
- Rheumatoid arthritis ( 24390342
23143596
30572963
30423114
)
- Rheumatoid arthritis (ACPA-negative) ( 23143596
)
- Rheumatoid arthritis (ACPA-positive) ( 24532676
23143596
)
- Sero-negative rheumatoid arthritis ( 28706201
)
- Serum alkaline phosphatase levels ( 33547301
)
- Triglycerides ( 20686565
)
- Type 1 diabetes ( 34127860
)
- Type 2 diabetes ( 29358691
22885922
26818947
26961502
27189021
32499647
30718926
30297969
28869590
)
- Urate levels ( 23263486
)
- Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993
)
- Vertical cup-disc ratio (multi-trait analysis) ( 31959993
)
- Waist-to-hip ratio adjusted for BMI ( 26426971
)
- Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625
)
- Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971
)
- Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500
)
- Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625
)
- Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500
)
- Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625
)
- Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971
)
- Waist-to-hip ratio adjusted for body mass index ( 28448500
25673412
)
|
No GWAS studies recorded
|
| Novel Interactors |
2 novel interactors:
SETD9
SNX18
|
None recorded
|
| Interacting Genes |
22 interacting genes:
ABI2
ANKS1A
BACH2
BANP
BOLA2
BOLA2B
CABP5
CFAP206
CLIC3
FHL2
FHL5
FRS3
HGS
HSF2BP
NCK2
NOXA1
PFDN5
PTK6
TEKT4
TRIM23
ZMYND19
ZSCAN1
|
35 interacting genes:
AGR2
ALX1
ANKRD23
ANKRD55
APP
CIMIP2B
DDIT4L
DNM1
EFHC2
GLYR1
INCA1
KATNBL1
KRT85
KRTAP13-3
LELP1
MAPK15
MBD3L1
MECOM
MIA3
MSX2
POT1
PROSER2
SCML4
SPMIP4
SPMIP6
STMN3
TBC1D3
TBC1D3C
TBC1D3K
TEPSIN
TLE5
VPS4A
ZBTB42
ZC2HC1C
ZNF620
|
| Entrez ID |
79722 |
9022 |
| HPRD ID |
07758
|
05941
|
| Ensembl ID |
ENSG00000164512
|
ENSG00000169583
|
| Uniprot IDs |
Q3KP44
|
O95833
|
| PDB IDs |
Not available
|
3FY7
3KJY
|
| GO Terms Enriched among Interactors |
|
None
|