ANKRD55 and SETD9

		ANKRD55	SETD9
Description		ankyrin repeat domain 55	SET domain containing 9
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Nucleoplasm Mitochondrion
	Molecular Function	Protein Binding	Protein Binding Methyltransferase Activity Lysine N-methyltransferase Activity Transferase Activity
	Biological Process		Methylation Regulation Of Signal Transduction By P53 Class Mediator
Pathways			Regulation of TP53 Activity through Methylation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Alzheimer's disease (cognitive decline) ( 23535033) Celiac disease or Rheumatoid arthritis ( 21383967) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) IgA levels ( 28628107) IgG glycosylation ( 23382691) Immature fraction of reticulocytes ( 32888494) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lung function (FEV1) ( 30061609) Macular thickness ( 30535121) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 24076602 27386562 31604244) Optic disc size ( 31809533) Pediatric autoimmune diseases ( 26301688) Post-traumatic stress disorder ( 27167565) Reticulocyte fraction of red cells ( 32888494) Rheumatoid arthritis ( 24390342 23143596 30572963 30423114) Rheumatoid arthritis (ACPA-negative) ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Sero-negative rheumatoid arthritis ( 28706201) Serum alkaline phosphatase levels ( 33547301) Triglycerides ( 20686565) Type 1 diabetes ( 34127860) Type 2 diabetes ( 29358691 22885922 26818947 26961502 27189021 32499647 30718926 30297969 28869590) Urate levels ( 23263486) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 28448500 25673412)	Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		22 interacting genes: ABI2 ANKS1A BACH2 BANP BOLA2 BOLA2B CABP5 CFAP206 CLIC3 FHL2 FHL5 FRS3 HGS HSF2BP NCK2 NOXA1 PFDN5 PTK6 TEKT4 TRIM23 ZMYND19 ZSCAN1	2 interacting genes: CRK PLCG2
Entrez ID		79722	133383
HPRD ID		07758	14572
Ensembl ID		ENSG00000164512	ENSG00000155542
Uniprot IDs		Q3KP44	Q8NE22
PDB IDs
Enriched GO Terms of Interacting Partners?		Cytoplasm Iron-sulfur Cluster Assembly Complex [2Fe-2S] Cluster Assembly	Response To Yeast Phosphotyrosine Residue Binding Protein Tyrosine Kinase Binding Response To Fungus Scaffold Protein Binding Helper T Cell Diapedesis Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin Cerebellar Neuron Development Inositol Trisphosphate Biosynthetic Process Follicular B Cell Differentiation Response To Hepatocyte Growth Factor Positive Regulation Of Locomotion Regulation Of Innate Immune Response Cellular Response To Nitric Oxide Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Cell Migration Positive Regulation Of Rac Protein Signal Transduction Diapedesis Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Motility Positive Regulation Of Receptor Clustering Regulation Of Receptor Clustering Insulin-like Growth Factor Receptor Binding Cellular Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Reelin-mediated Signaling Pathway Cellular Response To Reactive Nitrogen Species Response To Nitric Oxide Response To Endothelin Cellular Response To Endothelin Postsynaptic Specialization Assembly Positive Regulation Of Neuroinflammatory Response Regulation Of Dendritic Cell Cytokine Production Intracellular Vesicle Positive Regulation Of Interleukin-23 Production Macrophage Activation Involved In Immune Response Cellular Response To Lectin Antifungal Innate Immune Response Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Interleukin-23 Production Phospholipase C Activity Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Inositol Trisphosphate Metabolic Process Positive Regulation Of Dendritic Cell Cytokine Production Inositol Phosphate Biosynthetic Process Positive Regulation Of Phagocytosis, Engulfment Phosphorylation-dependent Protein Binding Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Postsynaptic Specialization Organization
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