BAG5 and ATP5MJ

Data Source: HiPPIP (Novel)

		BAG5	ATP5MJ
Name		BAG cochaperone 5	ATP synthase membrane subunit j
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Membrane Inclusion Body Junctional Membrane Complex Perinuclear Region Of Cytoplasm	Fibrillar Center Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Proton-transporting ATP Synthase Complex
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Protein-folding Chaperone Binding Ubiquitin Ligase Inhibitor Activity	Protein Binding
	Biological Process	Protein Folding Golgi Organization Negative Regulation Of Neuron Projection Development Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Stabilization Negative Regulation Of Protein Refolding Regulation Of Inclusion Body Assembly Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	Proton Motive Force-driven ATP Synthesis
Pathways		Regulation of HSF1-mediated heat shock response	Formation of ATP by chemiosmotic coupling Cristae formation
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Body mass index ( 26426971 ) Brain morphology (MOSTest) ( 32665545 ) Broad depression or schizophrenia ( 30626913 ) Depression ( 29700475 ) Schizophrenia ( 25056061 )	No GWAS studies recorded
Novel Interactors		5 novel interactors: ANXA3 ATP5MJ IGHG4 JMJD6 SIVA1	1 novel interactors: BAG5
Interacting Genes		19 interacting genes: BANP CDCA7L CIRBP CREBBP DES EFEMP1 FAM118B GOLGA6A KASH5 KRTAP5-4 LRRK1 PINK1 PRKN SNCA STUB1 THAP1 TP53 TRIM27 VCP	4 interacting genes: APOC1 CIDEB MTCH2 PIN1
Entrez ID		9529	9556
HPRD ID		04862	05199
Ensembl ID		ENSG00000166170	ENSG00000156411
Uniprot IDs		A0A024R6M6 Q9UL15	P56378
PDB IDs		2D9D 3A8Y	8H9F 8H9J 8H9M 8H9Q 8H9S 8H9T 8H9U 8H9V 8KHF 8KI3
GO Terms Enriched among Interactors		Regulation Of Mitophagy Regulation Of Autophagy Of Mitochondrion Positive Regulation Of ATP Biosynthetic Process Identical Protein Binding Dopamine Transport Regulation Of Purine Nucleotide Metabolic Process Mitochondrion To Lysosome Vesicle-mediated Transport Positive Regulation Of Mitophagy Cellular Response To Hydrogen Sulfide Regulation Of ATP Biosynthetic Process Regulation Of Dopamine Secretion Regulation Of Oxidative Phosphorylation Cellular Response To Topologically Incorrect Protein Positive Regulation Of Autophagy Of Mitochondrion Regulation Of Aerobic Respiration Positive Regulation Of Protein-containing Complex Assembly Monoamine Transport Regulation Of Protein Stability Regulation Of Autophagy Response To Hydrogen Sulfide Negative Regulation Of Autophagy Protein Stabilization Negative Regulation Of Mitochondrial Fission Positive Regulation Of ATP Metabolic Process Regulation Of Mitochondrion Organization Regulation Of Synaptic Vesicle Transport Regulation Of Catecholamine Secretion Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Protein-containing Complex Assembly Lewy Body Dopamine Uptake Involved In Synaptic Transmission Mitochondrion Organization Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Regulation Of Cellular Respiration Regulation Of Release Of Cytochrome C From Mitochondria Tau Protein Binding Positive Regulation Of Post-translational Protein Modification Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Reactive Oxygen Species Metabolic Process Hsp70 Protein Binding Autophagy Ubiquitin Protein Ligase Binding Positive Regulation Of Organelle Organization Macroautophagy Inclusion Body Assembly Positive Regulation Of Small Molecule Metabolic Process Mitophagy Fibrillar Center Protein Destabilization	Negative Regulation Of Catabolic Process Very-low-density Lipoprotein Particle Assembly Protein-lipid Complex Assembly Plasma Lipoprotein Particle Assembly Regulation Of Triglyceride Metabolic Process Establishment Of Protein Localization To Mitochondrion Negative Regulation Of Phosphatidylcholine Catabolic Process Cis-trans Isomerase Activity Regulation Of Phosphorus Metabolic Process Negative Regulation Of Small Molecule Metabolic Process Negative Regulation Of Protein Catabolic Process Negative Regulation Of Protein Refolding Establishment Of Protein Localization To Mitochondrial Membrane Involved In Mitochondrial Fission Negative Regulation Of Phosphate Metabolic Process Lipid Homeostasis Regulation Of Phosphatidylcholine Catabolic Process Protein Peptidyl-prolyl Isomerization Phosphothreonine Residue Binding Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Regulation Of Intrinsic Apoptotic Signaling Pathway Very-low-density Lipoprotein Particle Clearance Chylomicron Remnant Clearance Triglyceride-rich Lipoprotein Particle Clearance Negative Regulation Of Protein Folding Lipid Droplet Fusion Phosphatidylcholine-sterol O-acyltransferase Activator Activity Negative Regulation Of Triglyceride Catabolic Process Phosphoserine Residue Binding Junctional Membrane Complex Regulation Of Cellular Component Organization Regulation Of Primary Metabolic Process Protein Stabilization Regulation Of Phospholipid Catabolic Process Lipase Inhibitor Activity Organelle Organization Hematopoietic Stem Cell Migration Regulation Of Lipid Metabolic Process Lipid Transport Regulation Of Phosphatidylcholine Metabolic Process Chylomicron Regulation Of Small Molecule Metabolic Process Negative Regulation Of Metabolic Process Phospholipid Efflux Protein-containing Complex Assembly Phospholipase Inhibitor Activity Mitogen-activated Protein Kinase Kinase Binding GTPase Activating Protein Binding Ubiquitin Ligase Activator Activity Establishment Of Protein Localization To Organelle Regulation Of Protein Folding