BAG5 and CIRBP

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		BAG5	CIRBP
Name		BAG cochaperone 5	cold inducible RNA binding protein
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Membrane Inclusion Body Junctional Membrane Complex Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytoplasmic Stress Granule
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Protein-folding Chaperone Binding Ubiquitin Ligase Inhibitor Activity	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Translation Repressor Activity Small Ribosomal Subunit RRNA Binding
	Biological Process	Protein Folding Golgi Organization Negative Regulation Of Neuron Projection Development Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Stabilization Negative Regulation Of Protein Refolding Regulation Of Inclusion Body Assembly Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway	Response To Cold Response To UV Negative Regulation Of Translation Stress Granule Assembly Positive Regulation Of Translation Positive Regulation Of MRNA Splicing, Via Spliceosome MRNA Stabilization
Pathways		Regulation of HSF1-mediated heat shock response	None
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Body mass index ( 26426971 ) Brain morphology (MOSTest) ( 32665545 ) Broad depression or schizophrenia ( 30626913 ) Depression ( 29700475 ) Schizophrenia ( 25056061 )	Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 )
Novel Interactors		5 novel interactors: ANXA3 ATP5MJ IGHG4 JMJD6 SIVA1	None recorded
Interacting Genes		19 interacting genes: BANP CDCA7L CIRBP CREBBP DES EFEMP1 FAM118B GOLGA6A KASH5 KRTAP5-4 LRRK1 PINK1 PRKN SNCA STUB1 THAP1 TP53 TRIM27 VCP	21 interacting genes: APP ATXN1 BAG5 CEBPA CSNK2A1 FBXO7 HNRNPA0 HNRNPK IL7R KHDRBS1 KHDRBS2 LNX1 NEIL3 PRMT1 RBMX RBMY1A1 RBMY1F SNRPA SRF SRSF3 UBC
Entrez ID		9529	1153
HPRD ID		04862	08375
Ensembl ID		ENSG00000166170	ENSG00000099622
Uniprot IDs		A0A024R6M6 Q9UL15	D6W5Y5 K7EPM4 K7EQR7 Q14011 Q53XX5
PDB IDs		2D9D 3A8Y	1X5S 5TBX 8CMK
GO Terms Enriched among Interactors		Regulation Of Mitophagy Regulation Of Autophagy Of Mitochondrion Positive Regulation Of ATP Biosynthetic Process Identical Protein Binding Dopamine Transport Regulation Of Purine Nucleotide Metabolic Process Mitochondrion To Lysosome Vesicle-mediated Transport Positive Regulation Of Mitophagy Cellular Response To Hydrogen Sulfide Regulation Of ATP Biosynthetic Process Regulation Of Dopamine Secretion Regulation Of Oxidative Phosphorylation Cellular Response To Topologically Incorrect Protein Positive Regulation Of Autophagy Of Mitochondrion Regulation Of Aerobic Respiration Positive Regulation Of Protein-containing Complex Assembly Monoamine Transport Regulation Of Protein Stability Regulation Of Autophagy Response To Hydrogen Sulfide Negative Regulation Of Autophagy Protein Stabilization Negative Regulation Of Mitochondrial Fission Positive Regulation Of ATP Metabolic Process Regulation Of Mitochondrion Organization Regulation Of Synaptic Vesicle Transport Regulation Of Catecholamine Secretion Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Protein-containing Complex Assembly Lewy Body Dopamine Uptake Involved In Synaptic Transmission Mitochondrion Organization Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Regulation Of Cellular Respiration Regulation Of Release Of Cytochrome C From Mitochondria Tau Protein Binding Positive Regulation Of Post-translational Protein Modification Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Reactive Oxygen Species Metabolic Process Hsp70 Protein Binding Autophagy Ubiquitin Protein Ligase Binding Positive Regulation Of Organelle Organization Macroautophagy Inclusion Body Assembly Positive Regulation Of Small Molecule Metabolic Process Mitophagy Fibrillar Center Protein Destabilization	Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Regulation Of MRNA Processing Nucleic Acid Metabolic Process Nucleic Acid Binding RNA Metabolic Process MRNA Metabolic Process RNA Processing MRNA Processing Regulation Of RNA Splicing Nucleoplasm Regulation Of MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Binding RNA Splicing Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Spliceosomal Complex Poly(U) RNA Binding Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Gene Expression Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Memory Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of RNA Splicing Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Primary MiRNA Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Metabolic Process Protein Domain Specific Binding Negative Regulation Of RNA Metabolic Process Associative Learning Protein-containing Complex Chromatin Binding Negative Regulation Of MRNA Metabolic Process Regulation Of Amyloid-beta Clearance Poly(A) Binding