EPS8L3 and FASLG

Number of citations of the paper that reports this interaction (PubMedID 19807924)
40

Data Source:
BioGRID (unspecified method)

		EPS8L3	FASLG
Description		EPS8 signaling adaptor L3	Fas ligand
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Ruffle Membrane	Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Plasma Membrane Caveola External Side Of Plasma Membrane Cell Surface Membrane Cytoplasmic Vesicle Lysosomal Lumen Perinuclear Region Of Cytoplasm Cytoplasmic Vesicle Lumen Extracellular Exosome
	Molecular Function	Actin Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Actin Filament Binding	Signaling Receptor Binding Death Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Rho Protein Signal Transduction Regulation Of Rho Protein Signal Transduction Regulation Of Hair Cycle Positive Regulation Of Ruffle Assembly	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Inflammatory Cell Apoptotic Process Immune Response Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Angiogenesis Intracellular Chloride Ion Homeostasis Response To Lipopolysaccharide Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Retinal Cell Programmed Cell Death Endosomal Lumen Acidification T Cell Apoptotic Process Necroptotic Process Response To Growth Factor Cellular Response To Type II Interferon Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited Interleukin-4 and Interleukin-13 signaling Dimerization of procaspase-8 FasL/ CD95L signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models FOXO-mediated transcription of cell death genes TNFs bind their physiological receptors
Drugs
Diseases			Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Alcohol dependence ( 33290381) Colorectal cancer ( 31826910) Fibrinogen levels (smoking status, alcohol consumption or body mass index interaction) ( 25551457) Heel bone mineral density ( 30598549)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic sensitization ( 30013184) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 22057235 24999842 25920553 20190752) Crohn's disease ( 21102463 23128233) Daytime sleep phenotypes ( 27126917) Itch intensity from mosquito bite ( 28199695) Psoriasis ( 28537254) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 34127860) Vitiligo ( 27723757)
Interacting Genes		2 interacting genes: FASLG SRPK2	82 interacting genes: APBB1 ARHGAP9 BAIAP2L1 BTK CACNB3 CACNB4 CRK CYSRT1 DAXX DLG2 DMD DNMBP DOCK4 ECM1 EPS8L3 EZR FADD FAS FGR FN1 FNBP1 FYB1 FYN GRAP GRAP2 GRB2 HCK IHO1 ITK ITSN2 KALRN KMT2A KRT33B KRT40 KRTAP11-1 KRTAP12-3 LCK LYN MACC1 MIA MMP7 MPP4 MYO15A NCF1 NCK1 NCK2 NCKIPSD NOTCH2NLA OSTF1 PACSIN2 PDCD6 PIK3CA PIK3R1 PIN1 PPIAP11 PRPF40A PSTPIP1 PTPN13 RGS20 RIMBP3C SAMSN1 SEC23A SH3GL3 SH3PXD2A SH3PXD2B SH3RF2 SKAP2 SNX33 SNX9 SORBS3 SPTA1 SRC SRGAP1 SRGAP2 SRGAP3 SUMO1 TEC TJP3 TNFRSF6B TNS2 TRIP6 YES1
Entrez ID		79574	356
HPRD ID		13277	00610
Ensembl ID		ENSG00000198758	ENSG00000117560
Uniprot IDs		A8K2J6 Q8TE67	P48023 Q53ZZ1
PDB IDs		1WXT	4MSV 5L19 5L36
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Neuron Apoptotic Process Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of Phospholipid Translocation Cytoplasmic Vesicle Lumen Retinal Cell Programmed Cell Death Nuclear Speck Organization Inflammatory Cell Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Necroptotic Signaling Pathway Intracellular Chloride Ion Homeostasis R-loop Processing Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Positive Regulation Of Phospholipid Transport Endosomal Lumen Acidification Necroptotic Process Regulation Of Plasma Membrane Organization Death Receptor Binding Nuclear Body Organization Chloride Ion Homeostasis Programmed Necrotic Cell Death Monoatomic Anion Homeostasis Programmed Cell Death Involved In Cell Development Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway T Cell Apoptotic Process Tumor Necrosis Factor Receptor Binding Positive Regulation Of Viral Genome Replication 14-3-3 Protein Binding Positive Regulation Of ERBB Signaling Pathway Lymphocyte Apoptotic Process Immune Response Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Membrane Lipid Distribution Leukocyte Apoptotic Process Peptidyl-serine Phosphorylation Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Response To External Biotic Stimulus Regulation Of Endothelial Cell Apoptotic Process Regulation Of Apoptotic Process Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Intracellular PH Reduction Negative Regulation Of Sequestering Of Calcium Ion Regulation Of Programmed Cell Death Positive Regulation Of Viral Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway	Phosphotyrosine Residue Binding Non-membrane Spanning Protein Tyrosine Kinase Activity Cytosol Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Signal Transduction Antigen Receptor-mediated Signaling Pathway Immune Response-activating Signaling Pathway Regulation Of Immune Response Immune Response-regulating Signaling Pathway T Cell Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Activation Of Immune Response Regulation Of Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Fc Receptor Signaling Pathway Protein Tyrosine Kinase Activity Plasma Membrane Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Cellular Component Organization Cytoplasm Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Binding Peptidyl-tyrosine Phosphorylation Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Immune System Process Positive Regulation Of Immune Response Regulation Of Cell Shape Regulation Of Cell Morphogenesis Negative Regulation Of Immune System Process Regulation Of Actin Filament-based Process Positive Regulation Of Immune System Process T Cell Costimulation Regulation Of Cell Communication Regulation Of Signaling Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Regulation Of Signal Transduction Developmental Process Phospholipase Activator Activity Endocytosis B Cell Receptor Signaling Pathway Regulation Of Cell Motility Immune System Process Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Actin Polymerization Or Depolymerization Anchoring Junction Positive Regulation Of T Cell Activation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?