EPS8L3

Description		EPS8 signaling adaptor L3
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Ruffle Membrane
	Molecular Function	Actin Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Actin Filament Binding
	Biological Process	Rho Protein Signal Transduction Regulation Of Rho Protein Signal Transduction Regulation Of Hair Cycle Positive Regulation Of Ruffle Assembly
Pathways
Drugs
Diseases
GWAS		Alcohol dependence ( 33290381) Colorectal cancer ( 31826910) Fibrinogen levels (smoking status, alcohol consumption or body mass index interaction) ( 25551457) Heel bone mineral density ( 30598549)
Interacting Genes		2 interacting genes: FASLG SRPK2
Entrez ID		79574
HPRD ID		13277
Ensembl ID		ENSG00000198758
Uniprot IDs		A8K2J6 Q8TE67
PDB IDs		1WXT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Neuron Apoptotic Process Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of Phospholipid Translocation Cytoplasmic Vesicle Lumen Retinal Cell Programmed Cell Death Nuclear Speck Organization Inflammatory Cell Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Necroptotic Signaling Pathway Intracellular Chloride Ion Homeostasis R-loop Processing Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Positive Regulation Of Phospholipid Transport Endosomal Lumen Acidification Necroptotic Process Regulation Of Plasma Membrane Organization Death Receptor Binding Nuclear Body Organization Chloride Ion Homeostasis Programmed Necrotic Cell Death Monoatomic Anion Homeostasis Programmed Cell Death Involved In Cell Development Positive Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway T Cell Apoptotic Process Tumor Necrosis Factor Receptor Binding Positive Regulation Of Viral Genome Replication 14-3-3 Protein Binding Positive Regulation Of ERBB Signaling Pathway Lymphocyte Apoptotic Process Immune Response Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Membrane Lipid Distribution Leukocyte Apoptotic Process Peptidyl-serine Phosphorylation Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Response To External Biotic Stimulus Regulation Of Endothelial Cell Apoptotic Process Regulation Of Apoptotic Process Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Intracellular PH Reduction Negative Regulation Of Sequestering Of Calcium Ion Regulation Of Programmed Cell Death Positive Regulation Of Viral Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
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