FIGNL1 and ITGB1BP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		FIGNL1	ITGB1BP1
Description		fidgetin like 1	integrin subunit beta 1 binding protein 1
Image
GO Annotations	Cellular Component	Nuclear Chromosome Nucleus Nucleoplasm Cytoplasm Perinuclear Region Of Cytoplasm Extracellular Exosome	Ruffle Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Nuclear Body Lamellipodium Centriolar Satellite Cell Projection Perinuclear Region Of Cytoplasm Cell Periphery
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Binding ATP Binding Microtubule Severing ATPase Activity Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding	GDP-dissociation Inhibitor Activity Integrin Binding Protein Binding Kinase Binding Protein Kinase Binding
	Biological Process	Osteoblast Differentiation Male Meiotic Nuclear Division Regulation Of Double-strand Break Repair Via Homologous Recombination Osteoblast Proliferation Negative Regulation Of Apoptotic Process ATP Metabolic Process Microtubule Severing Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Angiogenesis Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Negative Regulation Of Protein Kinase Activity Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Cell Adhesion Cell-matrix Adhesion Notch Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Fibroblast Migration Cell Migration Cell Differentiation Negative Regulation Of Cell Migration Biomineral Tissue Development Negative Regulation Of Protein Binding Activation Of Protein Kinase B Activity Integrin Activation Regulation Of Cell Adhesion Mediated By Integrin Tube Formation Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of GTPase Activity Receptor Clustering Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Myoblast Migration Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Cell Division Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of ERK1 And ERK2 Cascade Protein Localization To Membrane Protein Localization To Plasma Membrane Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Protein Targeting To Membrane Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of Protein Targeting To Membrane Blood Vessel Diameter Maintenance Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Integrin-mediated Signaling Pathway
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Meiotic recombination
Drugs
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 21102463)
Interacting Genes		7 interacting genes: DMC1 FIRRM GCC1 IDH1 ITGB1BP1 KDM1A SPIDR	19 interacting genes: APP CAMK2A CCDC33 DLD EEF1A1 FAF1 FIGNL1 GSDME ITGB1 KRIT1 LRP1 LRP2 LRP8 RHOH SLC35F5 SMO SMURF1 SMURF2 UTRN
Entrez ID		63979	9270
HPRD ID		10958	06194
Ensembl ID		ENSG00000132436	ENSG00000119185
Uniprot IDs		B3KNH6 Q6PIW4	B4DQY5 O14713
PDB IDs		3D8B 8R64	4DX8 4DX9 4JIF
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Regulation Of Phosphorus Metabolic Process Glyoxylate Cycle Isocitrate Metabolic Process Isocitrate Dehydrogenase (NADP+) Activity Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Regulation Of Protein Modification Process Negative Regulation Of Protein Targeting To Membrane Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Recombinational Repair DNA Strand Invasion DNA Metabolic Process DNA Recombinase Assembly Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Strand Exchange Activity Chromosome Catalytic Activity, Acting On DNA Chromosome, Telomeric Region Cell Maturation Regulation Of DNA Recombination Response To Fungicide MRF Binding Regulation Of Double-strand Break Repair Guanine Metabolic Process Protein Demethylase Activity Telomeric Repeat-containing RNA Binding Cellular Response To Radiation Response To Ionizing Radiation Cellular Response To Ionizing Radiation FAD-dependent H3K4me/H3K4me3 Demethylase Activity Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Cellular Response To Camptothecin Regulation Of Phospholipid Catabolic Process Glyoxylate Metabolic Process Activation Of Protein Kinase B Activity Developmental Maturation DNA Damage Response Histone H3K4 Demethylase Activity Regulation Of Establishment Of Protein Localization To Chromosome Golgi Trans Cisterna Double-strand Break Repair Regulation Of DNA Repair Regulation Of Protein Kinase Activity DNA Recombination Double-strand Break Repair Involved In Meiotic Recombination Histone H3K9 Demethylase Activity Integrin Activation Regulation Of Kinase Activity	Apolipoprotein Binding Regulation Of Apoptotic Process Astrocyte Activation Low-density Lipoprotein Particle Receptor Activity Regulation Of Programmed Cell Death Receptor Complex Cargo Receptor Activity Positive Regulation Of Neurogenesis Regulation Of Cell Migration Astrocyte Activation Involved In Immune Response Positive Regulation Of Cell Development Negative Regulation Of Signal Transduction Regulation Of Cell Motility Positive Regulation Of Nervous System Development Positive Regulation Of Lysosomal Protein Catabolic Process Regulation Of Locomotion Regulation Of Cell Communication Regulation Of Signaling Regulation Of Spontaneous Synaptic Transmission Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Protein Catabolic Process In The Vacuole Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Cell Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Multicellular Organismal Process Regulation Of Neurogenesis Regulation Of Protein Catabolic Process Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Developmental Process Regulation Of Lysosomal Protein Catabolic Process Clathrin-coated Pit Retinoid Metabolic Process Endocytic Vesicle Membrane Positive Regulation Of Protein Catabolic Process Diterpenoid Metabolic Process Regulation Of Nervous System Development Endocytosis Protein Kinase Binding Cellular Response To Cholesterol Dendrite Terpenoid Metabolic Process Regulation Of Neural Precursor Cell Proliferation Signal Transduction Cell Surface Receptor Signaling Pathway Heparan Sulfate Proteoglycan Binding Neuron Projection Morphogenesis Developmental Process Transcytosis
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