FIGNL1 and ITGB1BP1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		FIGNL1	ITGB1BP1
Gene Name		fidgetin-like 1	integrin beta 1 binding protein 1
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nucleus Cytoplasm Extracellular Vesicular Exosome	Ruffle Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Membrane Lamellipodium Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Cell Periphery
	Molecular Function	Magnesium Ion Binding Protein Binding ATP Binding Microtubule-severing ATPase Activity Hydrolase Activity	GDP-dissociation Inhibitor Activity Integrin Binding Protein Binding Protein Transporter Activity Protein Kinase Binding Protein Complex Binding
	Biological Process	Osteoblast Differentiation Regulation Of Double-strand Break Repair Via Homologous Recombination Cytoplasmic Microtubule Organization Osteoblast Proliferation Negative Regulation Of Apoptotic Process ATP Metabolic Process Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Transcription, DNA-templated Negative Regulation Of Protein Kinase Activity Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Cell-matrix Adhesion Notch Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Fibroblast Migration Protein Transport Cell Migration Cell Differentiation Biomineral Tissue Development Negative Regulation Of Protein Binding Activation Of Protein Kinase B Activity Integrin Activation Regulation Of Cell Adhesion Mediated By Integrin Tube Formation Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Regulation Of Cdc42 GTPase Activity Receptor Clustering Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Blood Vessel Size Myoblast Migration Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Cell Division Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of Protein Targeting To Membrane Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Integrin-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Crohn's disease ( 21102463)
Protein-Protein Interactions		2 interactors: ITGB1BP1 KDM1A	10 interactors: APP CAMK2A EEF1A1 FAF1 FIGNL1 ITGB1 KRIT1 LRP1 LRP2 LRP8
Entrez ID		63979	9270
HPRD ID		10958	06194
Ensembl ID		ENSG00000132436	ENSG00000119185
Uniprot IDs		Q6PIW4	B4DQY5 O14713
PDB IDs		3D8B	1K11 4DX8 4DX9 4JIF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Protein Binding Negative Regulation Of Binding Regulation Of Protein Binding Regulation Of Primitive Erythrocyte Differentiation Regulation Of Binding Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Targeting To Membrane Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Integrin Activation Negative Regulation Of Histone H3-K4 Methylation Histone H3-K9 Demethylation Negative Regulation Of Fibroblast Migration Myoblast Migration Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Histone H3-K4 Demethylation Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Megakaryocyte Differentiation Positive Regulation Of Hormone Biosynthetic Process Cell Proliferation Negative Regulation Of Histone H3-K9 Methylation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Cell Proliferation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Granulocyte Differentiation Regulation Of Sprouting Angiogenesis Endothelial Cell Proliferation Negative Regulation Of Protein Metabolic Process Regulation Of Organelle Organization Regulation Of Megakaryocyte Differentiation Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Histone Methylation Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Adherens Junction Organization Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Histone H3-K4 Methylation Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Signal Transduction Regulation Of Hormone Biosynthetic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Notch Signaling Pathway Regulation Of Cdc42 GTPase Activity Positive Regulation Of Protein Targeting To Membrane	Response To Radiation Response To Abiotic Stimulus Response To Light Stimulus Phototransduction, Visible Light Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Regulation Of Apoptotic Process Detection Of Light Stimulus Regulation Of Cell Death Isoprenoid Metabolic Process Detection Of Abiotic Stimulus Regulation Of Signaling Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Stimulus Endocytosis Steroid Metabolic Process Brain Development Cellular Response To Ionizing Radiation Regulation Of Metabolic Process Head Development Visual Learning Visual Behavior Regulation Of Protein Tyrosine Kinase Activity Alcohol Metabolic Process Receptor-mediated Endocytosis Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Ammon Gyrus Development Beta-amyloid Clearance Associative Learning Response To External Stimulus Central Nervous System Development Response To Stimulus Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Cell Death Developmental Cell Growth Negative Regulation Of Intracellular Signal Transduction Blood Vessel Morphogenesis Blood Coagulation Hemostasis Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Forebrain Development Synaptic Growth At Neuromuscular Junction Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Signaling Blood Vessel Development Cholesterol Metabolic Process
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