FIGNL1 and FIRRM

Number of citations of the paper that reports this interaction (PubMedID 29608566)
71

Data Source:
BioGRID (two hybrid)

		FIGNL1	FIRRM
Description		fidgetin like 1	FIGNL1 interacting regulator of recombination and mitosis
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Nucleus Nucleoplasm Cytoplasm Perinuclear Region Of Cytoplasm Extracellular Exosome	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Spindle Cytosol Cytoskeleton Midbody Spindle Midzone
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Binding ATP Binding Microtubule Severing ATPase Activity Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding	Protein Binding Protein Kinase Binding
	Biological Process	Osteoblast Differentiation Male Meiotic Nuclear Division Regulation Of Double-strand Break Repair Via Homologous Recombination Osteoblast Proliferation Negative Regulation Of Apoptotic Process ATP Metabolic Process Microtubule Severing Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Mitotic Cell Cycle Chromosome Segregation Interstrand Cross-link Repair Regulation Of Protein Kinase Activity
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Meiotic recombination	Resolution of Sister Chromatid Cohesion Resolution of D-loop Structures through Holliday Junction Intermediates Meiotic recombination
Drugs
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 21102463)
Interacting Genes		7 interacting genes: DMC1 FIRRM GCC1 IDH1 ITGB1BP1 KDM1A SPIDR	5 interacting genes: APP DMC1 FIGNL1 P4HA3 RAD51
Entrez ID		63979	55732
HPRD ID		10958	07694
Ensembl ID		ENSG00000132436	ENSG00000000460
Uniprot IDs		B3KNH6 Q6PIW4	A0A1B0GUP7 A0A1B0GV14 B4E0A9 Q9NSG2
PDB IDs		3D8B 8R64
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Regulation Of Phosphorus Metabolic Process Glyoxylate Cycle Isocitrate Metabolic Process Isocitrate Dehydrogenase (NADP+) Activity Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Regulation Of Protein Modification Process Negative Regulation Of Protein Targeting To Membrane Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Recombinational Repair DNA Strand Invasion DNA Metabolic Process DNA Recombinase Assembly Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Strand Exchange Activity Chromosome Catalytic Activity, Acting On DNA Chromosome, Telomeric Region Cell Maturation Regulation Of DNA Recombination Response To Fungicide MRF Binding Regulation Of Double-strand Break Repair Guanine Metabolic Process Protein Demethylase Activity Telomeric Repeat-containing RNA Binding Cellular Response To Radiation Response To Ionizing Radiation Cellular Response To Ionizing Radiation FAD-dependent H3K4me/H3K4me3 Demethylase Activity Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Cellular Response To Camptothecin Regulation Of Phospholipid Catabolic Process Glyoxylate Metabolic Process Activation Of Protein Kinase B Activity Developmental Maturation DNA Damage Response Histone H3K4 Demethylase Activity Regulation Of Establishment Of Protein Localization To Chromosome Golgi Trans Cisterna Double-strand Break Repair Regulation Of DNA Repair Regulation Of Protein Kinase Activity DNA Recombination Double-strand Break Repair Involved In Meiotic Recombination Histone H3K9 Demethylase Activity Integrin Activation Regulation Of Kinase Activity	DNA Strand Exchange Activity Meiotic Nuclear Division DNA Strand Invasion DNA Recombinase Assembly Nuclear Division Double-strand Break Repair Involved In Meiotic Recombination Lateral Element ATP-dependent DNA Damage Sensor Activity Mitotic Recombination Reciprocal Meiotic Recombination Nuclear Chromosome ATP-dependent Activity, Acting On DNA Homologous Recombination Meiosis I Condensed Nuclear Chromosome Male Meiotic Nuclear Division Chromosome Organization Involved In Meiotic Cell Cycle Response To Radiation Meiosis I Cell Cycle Process Reproductive Process Cellular Response To Ionizing Radiation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Cellular Response To Stress Response To Glucoside Regulation Of Double-strand Break Repair Via Homologous Recombination Site Of Double-strand Break Single-stranded DNA Binding Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Meiotic Cell Cycle Mitotic Recombination-dependent Replication Fork Processing Double-stranded DNA Binding Presynaptic Intermediate Filament Cytoskeleton Double-strand Break Repair Via Homologous Recombination Perinuclear Region Of Cytoplasm Regulation Of DNA Recombination Recombinational Repair Response To Ionizing Radiation PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Cell Maturation Positive Regulation Of Endothelin Production Growth Cone Filopodium
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