FIGNL1 and DMC1

Number of citations of the paper that reports this interaction (PubMedID 29608566)
71

Data Source:
BioGRID (two hybrid, two hybrid)

		FIGNL1	DMC1
Description		fidgetin like 1	DNA meiotic recombinase 1
Image
GO Annotations	Cellular Component	Nuclear Chromosome Nucleus Nucleoplasm Cytoplasm Perinuclear Region Of Cytoplasm Extracellular Exosome	Chromosome, Telomeric Region Condensed Nuclear Chromosome Lateral Element Nucleus Nucleoplasm Chromosome Site Of Double-strand Break
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Protein Binding ATP Binding Microtubule Severing ATPase Activity Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding	DNA Strand Exchange Activity Nucleotide Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Identical Protein Binding Catalytic Activity, Acting On DNA ATP-dependent DNA Damage Sensor Activity
	Biological Process	Osteoblast Differentiation Male Meiotic Nuclear Division Regulation Of Double-strand Break Repair Via Homologous Recombination Osteoblast Proliferation Negative Regulation Of Apoptotic Process ATP Metabolic Process Microtubule Severing Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly Ovarian Follicle Development Oocyte Maturation DNA Metabolic Process DNA Repair Mitotic Recombination Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Male Meiosis I Gamete Generation Spermatogenesis Spermatid Development Female Gamete Generation DNA Strand Invasion Oogenesis Meiotic Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle Double-strand Break Repair Involved In Meiotic Recombination
Pathways		Resolution of D-loop Structures through Holliday Junction Intermediates Meiotic recombination	Meiotic recombination Meiotic recombination
Drugs			Imidazole
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Crohn's disease ( 21102463)	Gamma glutamyl transferase levels ( 29403010) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Menopause (age at onset) ( 26414677) Sleep duration ( 30846698)
Interacting Genes		7 interacting genes: DMC1 FIRRM GCC1 IDH1 ITGB1BP1 KDM1A SPIDR	20 interacting genes: BRCA2 FIGNL1 FIRRM GORASP2 KCTD17 LNX1 MCPH1 MSH4 NIF3L1 PIAS2 PICK1 PSMA3 RAD51 RAD51AP1 RAD54B RPA1 SDCBP SDCBP2 TRIM23 UBE2I
Entrez ID		63979	11144
HPRD ID		10958	04099
Ensembl ID		ENSG00000132436	ENSG00000100206
Uniprot IDs		B3KNH6 Q6PIW4	Q14565
PDB IDs		3D8B 8R64	1V5W 2ZJB 4HYY 6R3P 7C98 7C99 7C9C 7CGY 8QQE 8R2G
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Metabolic Process Regulation Of Phosphorus Metabolic Process Glyoxylate Cycle Isocitrate Metabolic Process Isocitrate Dehydrogenase (NADP+) Activity Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Regulation Of Protein Modification Process Negative Regulation Of Protein Targeting To Membrane Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Recombinational Repair DNA Strand Invasion DNA Metabolic Process DNA Recombinase Assembly Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Strand Exchange Activity Chromosome Catalytic Activity, Acting On DNA Chromosome, Telomeric Region Cell Maturation Regulation Of DNA Recombination Response To Fungicide MRF Binding Regulation Of Double-strand Break Repair Guanine Metabolic Process Protein Demethylase Activity Telomeric Repeat-containing RNA Binding Cellular Response To Radiation Response To Ionizing Radiation Cellular Response To Ionizing Radiation FAD-dependent H3K4me/H3K4me3 Demethylase Activity Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Cellular Response To Camptothecin Regulation Of Phospholipid Catabolic Process Glyoxylate Metabolic Process Activation Of Protein Kinase B Activity Developmental Maturation DNA Damage Response Histone H3K4 Demethylase Activity Regulation Of Establishment Of Protein Localization To Chromosome Golgi Trans Cisterna Double-strand Break Repair Regulation Of DNA Repair Regulation Of Protein Kinase Activity DNA Recombination Double-strand Break Repair Involved In Meiotic Recombination Histone H3K9 Demethylase Activity Integrin Activation Regulation Of Kinase Activity	Recombinational Repair Lateral Element Double-strand Break Repair Via Homologous Recombination Response To Ionizing Radiation DNA Recombination Mitotic Recombination-dependent Replication Fork Processing DNA Repair Mitotic Recombination Cellular Response To Ionizing Radiation Cellular Response To Stress Reciprocal Meiotic Recombination Double-strand Break Repair Nuclear Chromosome Single-stranded DNA Binding PML Body Identical Protein Binding Condensed Chromosome Meiotic Cell Cycle Homologous Recombination DNA Metabolic Process Interstrand Cross-link Repair Nuclear Ubiquitin Ligase Complex DNA Damage Response Condensed Nuclear Chromosome Cellular Response To Radiation Chromosome, Telomeric Region Reproductive Process Meiotic Nuclear Division Macromolecule Metabolic Process Telomere Maintenance Via Recombination Response To Radiation Regulation Of Double-strand Break Repair Via Homologous Recombination Nuclear Division ATP-dependent DNA Damage Sensor Activity Telomere Maintenance SUMO Transferase Activity Response To Stress Regulation Of DNA Damage Checkpoint Synaptonemal Complex Nucleoplasm Telomere Organization Response To X-ray Double-stranded DNA Binding Mismatch Repair Regulation Of DNA Recombination Telomere Maintenance Via Telomere Lengthening Chromosome Organization Nucleus Regulation Of Double-strand Break Repair Chromosome
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