IRX6 and PFDN5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IRX6	PFDN5
Description		iroquois homeobox 6	prefoldin subunit 5
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Cytoplasm Cytosol Prefoldin Complex Protein-containing Complex Intermediate Filament Cytoskeleton
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding	Amyloid-beta Binding Transcription Corepressor Activity Protein Binding Unfolded Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Development	Regulation Of DNA-templated Transcription Protein Folding Negative Regulation Of DNA-templated Transcription Retina Development In Camera-type Eye Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Amyloid Fibril Formation RNA Polymerase I Assembly RNA Polymerase II Core Complex Assembly RNA Polymerase III Assembly
Pathways			Prefoldin mediated transfer of substrate to CCT/TriC
Drugs
Diseases
GWAS		Hypospadias ( 25108383) Lack of premeditation ( 30718321) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355) Visceral fat ( 22589738)
Interacting Genes		11 interacting genes: ARID5A CRX GLRX3 HOXA1 KRTAP19-7 MEOX2 NFKBID PFDN5 TBX19 TLE5 TRIB3	113 interacting genes: ABI2 ANKRD55 ATOSB BCAS2 BCL6 BHLHE40 BRMS1 C10orf55 C10orf62 C22orf39 CALCOCO2 CCDC198 CEBPA CIMIP1 CSPP1 DMRT3 DOK4 DOK5 EEIG1 ELK3 ESPNL FAAP20 FAM110A FAM221A FAM222B FAM90A1 GLRX3 GLYCTK GPANK1 GSTO2 GUCD1 HAPLN2 HHEX HOXB9 HOXC8 IKBKG IKZF3 IL16 INCA1 IRX2 IRX6 ITSN1 KCTD9 KDM1A KLHL38 KLHL42 LARP4 LNX1 MAP2K5 METTL21A MISP MRPL45 MYC MYOT MYOZ1 NEUROG2 NOXA1 NTAQ1 PATZ1 PAX9 PFDN6 PHF1 PHF24 PILRA PITX1 PITX2 POGZ PRKAB2 PRPF18 PRR35 PSMB4 PSMB8 PSME3 RIBC1 RIPPLY1 RSRC2 RUSC1 SAXO1 SAXO4 SCNM1 SDCBP SHISA6 SLAIN1 SMAP1 SMG9 SNAI1 SNRNP25 SNRPB SOHLH1 SPAG8 SPG21 SPMIP2 SPMIP4 SYCE1L SYT17 TAF6L TBX3 TCF19 TFG TLE5 TP73 TRAPPC6A TRIM28 TUBA1B TUBA3C VAX2 VEZF1 VGLL1 WDR25 WHR1 YPEL5 ZC2HC1C ZNF148
Entrez ID		79190	5204
HPRD ID		12091	05359
Ensembl ID		ENSG00000159387	ENSG00000123349
Uniprot IDs		P78412	Q99471
PDB IDs			6NR8 6NR9 6NRB 6NRC 6NRD 7WU7
Enriched GO Terms of Interacting Partners?		Transcription Corepressor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of T-helper 17 Type Immune Response Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of T-helper 17 Type Immune Response Regulation Of Macromolecule Biosynthetic Process Nucleus Sequence-specific Double-stranded DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of Transcription By RNA Polymerase II Semicircular Canal Formation RNA Polymerase III Assembly RNA Polymerase I Assembly Regulation Of Macromolecule Metabolic Process Retina Development In Camera-type Eye Abducens Nerve Formation Optokinetic Behavior RNA Polymerase II Core Complex Assembly Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Sequence-specific DNA Binding Somite Specification Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of Adaptive Immune Response Ubiquitin-protein Transferase Regulator Activity Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of RNA Metabolic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of 3'-UTR-mediated MRNA Stabilization	Protein Binding Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process Pattern Specification Process MRF Binding Regionalization Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process E-box Binding Axonemal A Tubule Inner Sheath
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