BRCC3 and NUMA1

Number of citations of the paper that reports this interaction (PubMedID 26195665)
52

Data Source:
BioGRID (enzymatic study)

		BRCC3	NUMA1
Description		BRCA1/BRCA2-containing complex subunit 3	nuclear mitotic apparatus protein 1
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nuclear Ubiquitin Ligase Complex Spindle Pole Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton BRCA1-A Complex BRISC Complex	Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule Spindle Microtubule Plasma Membrane Cell Cortex Membrane Lateral Plasma Membrane Nuclear Matrix Dendrite Spindle Pole Centrosome Protein-containing Complex Microtubule Plus-end Microtubule Minus-end Neuronal Cell Body Cortical Microtubule Mitotic Spindle Astral Microtubule Extracellular Exosome Mitotic Spindle Microtubule Bundle Mitotic Spindle Pole Lateral Cell Cortex Cell Cortex Region Cytoplasmic Microtubule Bundle Mitotic Spindle Midzone
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Enzyme Regulator Activity Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding K63-linked Deubiquitinase Activity Metal-dependent Deubiquitinase Activity	Structural Molecule Activity Protein Binding Microtubule Binding Lipid Binding Tubulin Binding Protein Domain Specific Binding Phosphatidylinositol Binding Protein-containing Complex Binding Microtubule Plus-end Binding Microtubule Minus-end Binding Dynein Complex Binding Disordered Domain Specific Binding
	Biological Process	DNA Repair Regulation Of DNA Repair Double-strand Break Repair Chromatin Organization Proteolysis DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Response To X-ray Response To Ionizing Radiation Protein Deubiquitination NLRP3 Inflammasome Complex Assembly Mitotic G2/M Transition Checkpoint Positive Regulation Of DNA Repair Cell Division Protein K63-linked Deubiquitination Cellular Response To Ionizing Radiation DNA Repair-dependent Chromatin Remodeling Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of DNA Damage Checkpoint	Establishment Of Mitotic Spindle Orientation Microtubule Bundle Formation Nucleus Organization Chromosome Segregation Positive Regulation Of BMP Signaling Pathway Astral Microtubule Organization Positive Regulation Of Microtubule Polymerization Positive Regulation Of Intracellular Transport Positive Regulation Of Keratinocyte Differentiation Cell Division Meiotic Cell Cycle Positive Regulation Of Hair Follicle Development Positive Regulation Of Chromosome Segregation Anastral Spindle Assembly Regulation Of Mitotic Spindle Organization Regulation Of Metaphase Plate Congression Positive Regulation Of Protein Localization To Spindle Pole Body Positive Regulation Of Mitotic Spindle Elongation Positive Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Chromosome Separation Positive Regulation Of Spindle Assembly
Pathways		Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	Recruitment of NuMA to mitotic centrosomes Mitotic Prophase
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Venous thromboembolism ( 31676865)	Antibody level in response to infection ( 25758998) Microalbuminuria ( 31511532) Severe influenza A (H1N1) infection ( 26379185) Urinary albumin-to-creatinine ratio ( 31511532 31630189)
Interacting Genes		13 interacting genes: ANKRD11 BACH1 BRCA1 CD82 FANCG IFNAR1 ITSN1 NUMA1 SHMT2 SNAPC5 SUMO2 UBC UBE2D1	26 interacting genes: ABRAXAS2 ACTR1A BRAP BRCC3 CCDC57 CDK6 EPB41 EPB41L1 EPB41L2 ERG GMCL1 GNAI1 GPSM2 NCOA6 PIM1 RAD21 RAE1 RNF10 SMC1A SUMO2 TERF1 TERF2 TNKS USP7 YEATS4 YWHAQ
Entrez ID		79184	4926
HPRD ID		06465	01236
Ensembl ID		ENSG00000185515	ENSG00000137497
Uniprot IDs		P46736	Q14980 Q3SYK8
PDB IDs		6H3C 6R8F 8PVY 8PY2	3RO2 5GXW 6HC2 6QJA
Enriched GO Terms of Interacting Partners?		Nucleoplasm Post-translational Protein Modification Histone H2AK127 Ubiquitin Ligase Activity Damaged DNA Binding Tubulin Binding Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Type I Interferon Receptor Activity Type I Interferon Binding Regulation Of Cellular Respiration Interferon Receptor Activity Cortical Microtubule Anastral Spindle Assembly Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Lateral Cell Cortex Positive Regulation Of Mitotic Spindle Elongation Clathrin-dependent Synaptic Vesicle Endocytosis L-allo-threonine Aldolase Activity Glycine Hydroxymethyltransferase Activity Glycine Biosynthetic Process From Serine Protein Tag Activity Ubiquitin Protein Ligase Binding	Cell Division Positive Regulation Of Protein Localization To Cell Cortex Regulation Of Protein Localization To Cell Cortex Cytoskeleton Regulation Of Cell Cycle Spindle Pole Mitotic Spindle Pole Regulation Of Cell Cycle Process Regulation Of Telomere Capping Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Organelle Organization Positive Regulation Of Protein Localization To Cell Periphery Establishment Of Meiotic Sister Chromatid Cohesion Negative Regulation Of Chromosome Organization Cell Cortex Nucleoplasm Cytoskeleton Organization Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cortical Actin Cytoskeleton Organization Mitotic Spindle Organization Negative Regulation Of Cell Cycle Positive Regulation Of Chromosome Organization Meiotic Cohesin Complex Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Regulation Of Chromosome Organization Regulation Of Establishment Of Protein Localization To Telomere Shelterin Complex BRISC Complex Regulation Of Mitotic Spindle Organization Positive Regulation Of Metabolic Process Centrosome Cortical Cytoskeleton Organization Regulation Of Organelle Organization Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Nuclear Matrix Mitotic Cohesin Complex Regulation Of Telomere Maintenance Via Telomerase Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Activity Microtubule Cytoskeleton Organization Involved In Mitosis Negative Regulation Of Cell Cycle Process Establishment Of Sister Chromatid Cohesion Positive Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Nuclear Telomere Cap Complex Telomeric D-loop Disassembly Double-stranded Telomeric DNA Binding
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