BRCC3 and IFNAR1

Number of citations of the paper that reports this interaction (PubMedID 24075985)
47

Data Source:
BioGRID (enzymatic study)

		BRCC3	IFNAR1
Description		BRCA1/BRCA2-containing complex subunit 3	interferon alpha and beta receptor subunit 1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nuclear Ubiquitin Ligase Complex Spindle Pole Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton BRCA1-A Complex BRISC Complex	Lysosome Endosome Late Endosome Plasma Membrane Membrane Receptor Complex
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Enzyme Regulator Activity Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding K63-linked Deubiquitinase Activity Metal-dependent Deubiquitinase Activity	Interferon Receptor Activity Type I Interferon Receptor Activity Protein Binding JAK Pathway Signal Transduction Adaptor Activity Cytokine Binding Type I Interferon Binding
	Biological Process	DNA Repair Regulation Of DNA Repair Double-strand Break Repair Chromatin Organization Proteolysis DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Response To X-ray Response To Ionizing Radiation Protein Deubiquitination NLRP3 Inflammasome Complex Assembly Mitotic G2/M Transition Checkpoint Positive Regulation Of DNA Repair Cell Division Protein K63-linked Deubiquitination Cellular Response To Ionizing Radiation DNA Repair-dependent Chromatin Remodeling Positive Regulation Of NLRP3 Inflammasome Complex Assembly Regulation Of DNA Damage Checkpoint	Regulation Of Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Via JAK-STAT Response To Virus Positive Regulation Of Metabolic Process Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interferon-alpha Cellular Response To Interferon-beta Regulation Of Receptor Signaling Pathway Via JAK-STAT Type I Interferon-mediated Signaling Pathway Cellular Response To Virus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Cellular Respiration
Pathways		Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling Potential therapeutics for SARS SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon alfa-2a Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon alfa-2b Interferon alfa Human interferon omega-1 Peginterferon beta-1a Anifrolumab Human interferon beta Ropeginterferon alfa-2b
Diseases
GWAS		Venous thromboembolism ( 31676865)	Blood protein levels ( 30072576) Crohn's disease ( 23128233) Psoriasis ( 25903422)
Interacting Genes		13 interacting genes: ANKRD11 BACH1 BRCA1 CD82 FANCG IFNAR1 ITSN1 NUMA1 SHMT2 SNAPC5 SUMO2 UBC UBE2D1	26 interacting genes: BRCC3 CRKL FBXW11 IFNA1 IFNA2 IFNAR2 IFNB1 IFNW1 LAPTM4B LCK LRPAP1 MAPK1 PIK3R1 PRKACA PRKD2 PRMT1 PTPN11 PTPN6 PTPRC RACK1 SOCS1 STAT2 STAT3 TYK2 USP7 ZAP70
Entrez ID		79184	3454
HPRD ID		06465	00126
Ensembl ID		ENSG00000185515	ENSG00000142166
Uniprot IDs		P46736	A0A8V8TQK8 A0A994J6F6 P17181
PDB IDs		6H3C 6R8F 8PVY 8PY2	3S98 3SE3 3SE4 4PO6 8Y31
Enriched GO Terms of Interacting Partners?		Nucleoplasm Post-translational Protein Modification Histone H2AK127 Ubiquitin Ligase Activity Damaged DNA Binding Tubulin Binding Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Type I Interferon Receptor Activity Type I Interferon Binding Regulation Of Cellular Respiration Interferon Receptor Activity Cortical Microtubule Anastral Spindle Assembly Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Lateral Cell Cortex Positive Regulation Of Mitotic Spindle Elongation Clathrin-dependent Synaptic Vesicle Endocytosis L-allo-threonine Aldolase Activity Glycine Hydroxymethyltransferase Activity Glycine Biosynthetic Process From Serine Protein Tag Activity Ubiquitin Protein Ligase Binding	Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Signal Transduction Type I Interferon-mediated Signaling Pathway Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Interferon-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Immune System Process T Cell Receptor Signaling Pathway Regulation Of Immune Response Cytokine Receptor Binding Regulation Of Hemopoiesis T Cell Activation Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Cell Adhesion Type I Interferon Receptor Binding Regulation Of Cytokine Production Cellular Response To Virus Positive Regulation Of Signal Transduction Protein Modification Process Natural Killer Cell Activation Involved In Immune Response Antigen Receptor-mediated Signaling Pathway Leukocyte Activation Involved In Immune Response Positive Regulation Of Intracellular Signal Transduction Response To Exogenous DsRNA Regulation Of Intracellular Signal Transduction Cell Activation Involved In Immune Response Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Regulation Of Developmental Process Leukocyte Activation Response To DsRNA Positive Regulation Of Immune System Process B Cell Activation Regulation Of Multicellular Organismal Process Immune System Process Lymphocyte Activation Natural Killer Cell Activation Cell Activation Phosphate-containing Compound Metabolic Process Negative Regulation Of Cytokine Production Regulation Of Lymphocyte Differentiation Positive Regulation Of Cell Adhesion Negative Regulation Of Gene Expression
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