P4HA2 and TNS4

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		P4HA2	TNS4
Description		prolyl 4-hydroxylase subunit alpha 2	tensin 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Anchoring Junction
	Molecular Function	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen L-ascorbic Acid Binding Metal Ion Binding Dioxygenase Activity	Actin Binding Protein Binding
	Biological Process		Intracellular Protein Localization
Pathways		Collagen biosynthesis and modifying enzymes	MET interacts with TNS proteins
Drugs		Proline
Diseases
GWAS		Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 22412388 28067908) Giant cell arteritis ( 28041642) Height ( 28552196) Inflammatory bowel disease ( 28067908) Intracranial aneurysm ( 33199917) Intraocular pressure ( 29617998) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Ulcerative colitis ( 28067908) Youthful appearance (self-reported) ( 32339537)	Asthma ( 31959851) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042)
Interacting Genes		7 interacting genes: CLNK CREB3 FHL3 OGT P4HB PRRC2A TNS4	23 interacting genes: AR CARD9 CYSRT1 EGFR ERBB3 ERBB4 GAB1 GSTCD HSF2BP KAZN KCTD4 MET NME4 NR3C1 P4HA2 PIH1D1 PIK3R1 RABEP1 RPAIN TRIM21 TRIM27 TXK ZRANB1
Entrez ID		8974	84951
HPRD ID		11862	12223
Ensembl ID		ENSG00000072682	ENSG00000131746
Uniprot IDs		O15460 Q05DA4	Q6PJP3 Q8IZW8
PDB IDs		6EVL 6EVM 6EVN 6EVO 6EVP 7ZSC
Enriched GO Terms of Interacting Partners?		Focal Adhesion	Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Basal Plasma Membrane Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway ERBB2 Signaling Pathway Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process ErbB-3 Class Receptor Binding Positive Regulation Of Biosynthetic Process Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of MiRNA Transcription Regulation Of Signal Transduction Positive Regulation Of MiRNA Metabolic Process Estrogen Response Element Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Epithelial Cell Proliferation Regulation Of MiRNA Transcription Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Eyelid Development In Camera-type Eye Receptor Complex Morphogenesis Of An Epithelial Fold Kinase Activity Negative Regulation Of Programmed Cell Death ATPase Binding Protein Tyrosine Kinase Activator Activity Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Viral Transcription Mammary Gland Alveolus Development Suppression Of Viral Release By Host Regulation Of MiRNA Metabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Phosphatase Binding Positive Regulation Of Metabolic Process Regulation Of Cell Communication Positive Regulation Of Multicellular Organismal Process
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