MELTF and HPGDS

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		MELTF	HPGDS
Description		melanotransferrin	hematopoietic prostaglandin D synthase
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface Membrane Recycling Endosome Extracellular Exosome Side Of Membrane	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Iron Ion Binding Protein Binding Metal Ion Binding	Magnesium Ion Binding Glutathione Transferase Activity Prostaglandin-D Synthase Activity Calcium Ion Binding Protein Binding Transferase Activity Isomerase Activity Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Regulation Of Cell Growth Monoatomic Ion Transport Iron Ion Transport Positive Regulation Of Plasminogen Activation Regulation Of Cell Population Proliferation Positive Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Substrate Adhesion-dependent Cell Spreading	Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Glutathione Metabolic Process Signal Transduction Locomotory Behavior Response To Nematode Response To Selenium Ion Negative Regulation Of Male Germ Cell Proliferation
Pathways		Post-translational modification: synthesis of GPI-anchored proteins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Glutathione conjugation Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs			Glutathione Tretinoin 2-(2f-Benzothiazolyl)-5-Styryl-3-(4f-Phthalhydrazidyl)Tetrazolium Chloride Glutathione disulfide Deoxycholic acid 3-phenyl-5-(1H-pyrazol-3-yl)isoxazole PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE Tranilast 4-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acid 4-(BENZHYDRYLOXY)-1-[3-(1H-TETRAAZOL-5-YL)PROPYL]PIPERIDINE Nocodazole 3-(4-nitrophenyl)-1H-pyrazole 1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
Diseases
GWAS		Malaria ( 31844061)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Blood protein levels ( 30072576) Testicular germ cell tumor ( 23666239 28604728 28604732)
Interacting Genes		11 interacting genes: CFTR CYSRT1 DERL1 DERL2 DERL3 HPGDS KRTAP1-1 KRTAP10-8 MESD NBPF19 NOTCH2NLA	7 interacting genes: ABHD17A ARRDC3 C14orf39 HK3 LIF MELTF PDE3B
Entrez ID		4241	27306
HPRD ID		01122	04001
Ensembl ID		ENSG00000163975	ENSG00000163106
Uniprot IDs		P08582 Q53XS6	A0A384P5J0 O60760
PDB IDs		6XR0	1IYH 1IYI 1V40 2CVD 2VCQ 2VCW 2VCX 2VCZ 2VD0 2VD1 3EE2 3KXO 3VI5 3VI7 4EC0 4EDY 4EDZ 4EE0 5AIS 5AIV 5AIX 5YWE 5YWX 5YX1 6N4E 6W58 6W8H 6ZTC 7JR6 7JR8
Enriched GO Terms of Interacting Partners?		Signal Recognition Particle Binding Response To Endoplasmic Reticulum Stress Regulation Of Cellular Localization Negative Regulation Of Protein Exit From Endoplasmic Reticulum Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Retrograde Protein Transport, ER To Cytosol ERAD Pathway Regulation Of Retrograde Protein Transport, ER To Cytosol Retrograde Protein Transport, ER To Cytosol Regulation Of Protein Exit From Endoplasmic Reticulum Regulation Of Intracellular Protein Transport Regulation Of Protein Transport Protein Exit From Endoplasmic Reticulum Regulation Of Protein Localization Negative Regulation Of Intracellular Protein Transport Regulation Of Establishment Of Protein Localization Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Protein Destabilization Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Regulation Of Intracellular Transport Negative Regulation Of Intracellular Transport Early Endosome Positive Regulation Of Anion Channel Activity Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Derlin-1-VIMP Complex Response To Unfolded Protein Positive Regulation Of Monoatomic Anion Transport N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Peptide Lactyltransferase (CoA-dependent) Activity Prostaglandin-D Synthase Activity Negative Regulation Of Male Germ Cell Proliferation Protein-containing Complex Binding Keratin Filament	Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Heat Generation Hexokinase Activity Mannokinase Activity Glucokinase Activity Fructokinase Activity Leukemia Inhibitory Factor Signaling Pathway Leukemia Inhibitory Factor Receptor Binding Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Locomotion Involved In Locomotory Behavior Beta-3 Adrenergic Receptor Binding Negative Regulation Of Protein Localization To Microtubule Meiotic DNA Double-strand Break Processing Involved In Reciprocal Meiotic Recombination Meiotic DNA Double-strand Break Processing Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Postsynaptic Recycling Endosome Membrane Protein Depalmitoylation Positive Regulation Of Protein Metabolic Process Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Regulation Of Cell Adhesion Muscle Organ Morphogenesis Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Lung Lobe Morphogenesis Positive Regulation Of Plasminogen Activation Guanyl-nucleotide Exchange Factor Complex Regulation Of Locomotion Involved In Locomotory Behavior Heat Generation Central Element
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