MFI2 and HPGDS

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		MFI2	HPGDS
Gene Name		antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5	hematopoietic prostaglandin D synthase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Cell Surface Anchored Component Of Plasma Membrane Extracellular Vesicular Exosome	Cytoplasm Cytosol
	Molecular Function	Iron Ion Binding Protein Binding Ferric Iron Binding	Magnesium Ion Binding Glutathione Transferase Activity Prostaglandin-D Synthase Activity Calcium Ion Binding Protein Homodimerization Activity
	Biological Process	Regulation Of Cell Growth Cellular Iron Ion Homeostasis Positive Regulation Of Plasminogen Activation Regulation Of Cell Proliferation Positive Regulation Of Extracellular Matrix Disassembly Iron Ion Import Negative Regulation Of Substrate Adhesion-dependent Cell Spreading	Prostaglandin Metabolic Process Xenobiotic Metabolic Process Signal Transduction Locomotory Behavior Arachidonic Acid Metabolic Process Cyclooxygenase Pathway Small Molecule Metabolic Process Glutathione Derivative Biosynthetic Process
Pathways			Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Metabolism of lipids and lipoproteins Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective UGT1A4 causes hyperbilirubinemia Glutathione conjugation Metabolic disorders of biological oxidation enzymes Arachidonic acid metabolism Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GGT1 causes Glutathionuria (GLUTH) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs			Glutathione 2-(2f-Benzothiazolyl)-5-Styryl-3-(4f-Phthalhydrazidyl)Tetrazolium Chloride Glycerol 3-phenyl-5-(1H-pyrazol-3-yl)isoxazole PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE 2-{[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enoyl]amino}benzoic acid 4-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acid 4-(BENZHYDRYLOXY)-1-[3-(1H-TETRAAZOL-5-YL)PROPYL]PIPERIDINE nocodazole 3-(4-nitrophenyl)-1H-pyrazole 1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
Diseases
GWAS			Testicular germ cell tumor ( 23666239)
Protein-Protein Interactions		5 interactors: DERL1 DERL2 DERL3 HPGDS NOTCH2NL	4 interactors: ABHD17A ARRDC3 HK3 MFI2
Entrez ID		4241	27306
HPRD ID		01122	04001
Ensembl ID		ENSG00000163975	ENSG00000163106
Uniprot IDs		P08582 Q53XS6	O60760
PDB IDs			1IYH 1IYI 1V40 2CVD 2VCQ 2VCW 2VCX 2VCZ 2VD0 2VD1 3EE2 3KXO 3VI5 3VI7 4EC0 4EDY 4EDZ 4EE0
Enriched GO Terms of Interacting Partners?		ER-associated Ubiquitin-dependent Protein Catabolic Process Retrograde Protein Transport, ER To Cytosol Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Signal Transduction Signaling Cell Communication Intracellular Transport Of Viral Protein In Host Cell Cellular Response To Stimulus Cellular Response To Stress Proteolysis Cyclooxygenase Pathway Catabolic Process Cellular Response To Organic Substance Prostaglandin Biosynthetic Process Suckling Behavior Glutathione Derivative Biosynthetic Process Response To Stimulus Protein Destabilization Intracellular Transport Of Virus Behavior Prostaglandin Metabolic Process Icosanoid Biosynthetic Process Response To Organic Substance Unsaturated Fatty Acid Biosynthetic Process Intracellular Protein Transport Arachidonic Acid Metabolic Process Icosanoid Metabolic Process Feeding Behavior Protein N-linked Glycosylation Via Asparagine Interaction With Host Unsaturated Fatty Acid Metabolic Process Response To Stress	Negative Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Heat Generation Positive Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Locomotion Involved In Locomotory Behavior Positive Regulation Of Extracellular Matrix Disassembly Homeostatic Process Positive Regulation Of Plasminogen Activation Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Fat Pad Development Negative Regulation Of Multicellular Organismal Metabolic Process Iron Ion Import Cellular Chemical Homeostasis Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Protein Processing Temperature Homeostasis Cellular Homeostasis Regulation Of Extracellular Matrix Disassembly Regulation Of Substrate Adhesion-dependent Cell Spreading Glucose 6-phosphate Metabolic Process Adipose Tissue Development Regulation Of Extracellular Matrix Organization Chemical Homeostasis Negative Regulation Of Cell-substrate Adhesion Carbohydrate Phosphorylation Glucose Transport Positive Regulation Of Ubiquitin-protein Transferase Activity Cellular Glucose Homeostasis Positive Regulation Of Ligase Activity Hexose Transport Iron Ion Transport
Tagcloud ?			11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc infertility peritoneal pgd2 pgf2alpha pgh2 pla2g2a pla2g4a provokes ptgds ptgfr ptgs2 reaches slco2a synthases
Tagcloud (Difference) ?			11beta 9alpha abcc4 akr1b1 akr1c1 akr1c3 catalyze diseased endometriosis endometriotic endometrium gynecological hieec hiesc infertility peritoneal pgd2 pgf2alpha pgh2 pla2g2a pla2g4a provokes ptgds ptgfr ptgs2 reaches slco2a synthases
Tagcloud (Intersection) ?