MFI2 and DERL2

Number of citations of the paper that reports this interaction (PMID 16449192)
22

Data Source:
HPRD (in vivo)

		MFI2	DERL2
Gene Name		antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5	derlin 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Cell Surface Anchored Component Of Plasma Membrane Extracellular Vesicular Exosome	Early Endosome Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Iron Ion Binding Protein Binding Ferric Iron Binding	Protein Binding
	Biological Process	Regulation Of Cell Growth Cellular Iron Ion Homeostasis Positive Regulation Of Plasminogen Activation Regulation Of Cell Proliferation Positive Regulation Of Extracellular Matrix Disassembly Iron Ion Import Negative Regulation Of Substrate Adhesion-dependent Cell Spreading	Suckling Behavior Positive Regulation Of Cell Proliferation Positive Regulation Of Cell Growth ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol
Pathways			Hedgehog ligand biogenesis Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease Signaling by Hedgehog
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: DERL1 DERL2 DERL3 HPGDS NOTCH2NL	5 interactors: KRTAP10-3 KRTAP10-7 KRTAP10-8 MFI2 SERPINA1
Entrez ID		4241	51009
HPRD ID		01122	16796
Ensembl ID		ENSG00000163975
Uniprot IDs		P08582 Q53XS6	Q9GZP9
PDB IDs
Enriched GO Terms of Interacting Partners?		ER-associated Ubiquitin-dependent Protein Catabolic Process Retrograde Protein Transport, ER To Cytosol Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Unfolded Protein Response To Endoplasmic Reticulum Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Signal Transduction Signaling Cell Communication Intracellular Transport Of Viral Protein In Host Cell Cellular Response To Stimulus Cellular Response To Stress Proteolysis Cyclooxygenase Pathway Catabolic Process Cellular Response To Organic Substance Prostaglandin Biosynthetic Process Suckling Behavior Glutathione Derivative Biosynthetic Process Response To Stimulus Protein Destabilization Intracellular Transport Of Virus Behavior Prostaglandin Metabolic Process Icosanoid Biosynthetic Process Response To Organic Substance Unsaturated Fatty Acid Biosynthetic Process Intracellular Protein Transport Arachidonic Acid Metabolic Process Icosanoid Metabolic Process Feeding Behavior Protein N-linked Glycosylation Via Asparagine Interaction With Host Unsaturated Fatty Acid Metabolic Process Response To Stress	Response To Methanol Response To Triglyceride Regulation Of Protein Processing Response To Chromate Positive Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Plasminogen Activation Negative Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Serine-type Peptidase Activity Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Iron Ion Import Positive Regulation Of Protein Processing Response To Lead Ion Regulation Of Extracellular Matrix Disassembly Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Extracellular Matrix Organization Acute-phase Response Negative Regulation Of Cell-substrate Adhesion Platelet Degranulation Acute Inflammatory Response Iron Ion Transport Cellular Iron Ion Homeostasis Negative Regulation Of Cell Morphogenesis Involved In Differentiation Regulation Of Protein Metabolic Process Iron Ion Homeostasis Response To Estradiol Transition Metal Ion Homeostasis
Tagcloud ?			apparatus cdt cdts chimeras complementation cytolethal derl1 derlin dispensable distending ducreyi erad evasion exit exotoxins exploited haemophilus hrd1 intoxication p97 reaching retrograde retrotranslocation ricin toxins trafficked uncharacterized undescribed wr
Tagcloud (Difference) ?			apparatus cdt cdts chimeras complementation cytolethal derl1 derlin dispensable distending ducreyi erad evasion exit exotoxins exploited haemophilus hrd1 intoxication p97 reaching retrograde retrotranslocation ricin toxins trafficked uncharacterized undescribed wr
Tagcloud (Intersection) ?