MELTF and KRTAP1-1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MELTF	KRTAP1-1
Description		melanotransferrin	keratin associated protein 1-1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface Membrane Recycling Endosome Extracellular Exosome Side Of Membrane	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Iron Ion Binding Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Regulation Of Cell Growth Monoatomic Ion Transport Iron Ion Transport Positive Regulation Of Plasminogen Activation Regulation Of Cell Population Proliferation Positive Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Post-translational modification: synthesis of GPI-anchored proteins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Keratinization
Drugs
Diseases
GWAS		Malaria ( 31844061)
Interacting Genes		11 interacting genes: CFTR CYSRT1 DERL1 DERL2 DERL3 HPGDS KRTAP1-1 KRTAP10-8 MESD NBPF19 NOTCH2NLA	218 interacting genes: ADAM12 ADAMTSL3 ADAMTSL4 AGXT AKR7A3 ALDH3B1 ALPP AQP1 ASPSCR1 ATG9A BCAM C10orf62 C11orf87 C19orf38 CAMK2B CATIP CATSPER1 CD300LG CERK CHIC2 CHRD CHRNG CLDN2 CNNM3 CREB5 CRH CRY2 CSF1 CST2 CTRC CTSZ CYSLTR2 CYSRT1 DHRS1 DMRT3 DOCK2 DRD5 EFNA3 EMC7 FAM221A FAM76B FAM90A1 FARS2 FBXW5 FEZF1 FKBP1B FOXD4L3 FRS3 FZD10 GARIN6 GLP1R GLYAT GNE GRN GSTP1 GUCD1 HCK HEY2 HHEX HOXA1 HOXB5 HOXB9 HOXC8 HPCAL1 HSBP1 HSPA12B HYAL2 IFITM2 IGSF8 IL16 INS ITGB4 ITGB5 JOSD1 KLHL38 KLK8 KRT20 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-3 KRTAP13-2 KRTAP2-3 KRTAP2-4 KRTAP26-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LNX1 LRFN4 LRRN4 MAGOHB MAPKBP1 MELTF MGAT5B MRGBP MRPL23 MT1B MXD3 MXI1 MYOM1 NECTIN2 NECTIN3 NMU NPDC1 NR1D2 NTM NUBP2 NUFIP2 OLFM2 OLIG3 OR14I1 OTX1 P2RX4 P2RY6 PCSK5 PDE9A PGAP6 PHLDA1 POU4F2 PRF1 PRKAB2 PRKAG1 PRPF31 PSMA1 PTK7 PTPMT1 PVR QPRT R3HDM2 RASD1 REM2 RNF111 RPS19BP1 RPS28 RPUSD3 RTN4RL1 SCARF1 SCNM1 SDC3 SEMA3B SHFL SLC23A1 SLC43A2 SLC68A1 SLC6A20 SLC7A11 SLIT1 SMARCE1 SMCP SMOC1 SNAI1 SNX18 SPACA9 SPRY1 STK16 TAPBPL TCEANC TFAP2D TGFB1 TLE5 TNP2 TSFM VASN VGLL3 VSTM4 WNT11 ZBTB48 ZBTB9 ZDHHC1 ZFTRAF1 ZNF124 ZNF330 ZNF408 ZNF414 ZNF417 ZNF439 ZNF440 ZNF446 ZNF491 ZNF497 ZNF524 ZNF581 ZNF587 ZNF648 ZNF669 ZNF696 ZNF786 ZNF837
Entrez ID		4241	81851
HPRD ID		01122	12304
Ensembl ID		ENSG00000163975	ENSG00000188581
Uniprot IDs		P08582 Q53XS6	Q07627
PDB IDs		6XR0
Enriched GO Terms of Interacting Partners?		Signal Recognition Particle Binding Response To Endoplasmic Reticulum Stress Regulation Of Cellular Localization Negative Regulation Of Protein Exit From Endoplasmic Reticulum Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Retrograde Protein Transport, ER To Cytosol ERAD Pathway Regulation Of Retrograde Protein Transport, ER To Cytosol Retrograde Protein Transport, ER To Cytosol Regulation Of Protein Exit From Endoplasmic Reticulum Regulation Of Intracellular Protein Transport Regulation Of Protein Transport Protein Exit From Endoplasmic Reticulum Regulation Of Protein Localization Negative Regulation Of Intracellular Protein Transport Regulation Of Establishment Of Protein Localization Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Protein Destabilization Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Regulation Of Intracellular Transport Negative Regulation Of Intracellular Transport Early Endosome Positive Regulation Of Anion Channel Activity Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Derlin-1-VIMP Complex Response To Unfolded Protein Positive Regulation Of Monoatomic Anion Transport N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Peptide Lactyltransferase (CoA-dependent) Activity Prostaglandin-D Synthase Activity Negative Regulation Of Male Germ Cell Proliferation Protein-containing Complex Binding Keratin Filament	Protein Binding Intermediate Filament Keratin Filament Keratinization Epidermis Development Tissue Development Hair Cycle Identical Protein Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Susceptibility To T Cell Mediated Cytotoxicity
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