TMEM109 and AQP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM109	AQP2
Description		transmembrane protein 109	aquaporin 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Sarcoplasmic Reticulum Membrane Monoatomic Ion Channel Complex Extracellular Exosome	Cytoplasm Golgi Apparatus Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Lumenal Side Of Membrane
	Molecular Function	Protein Binding Voltage-gated Monoatomic Cation Channel Activity	Water Transmembrane Transporter Activity Protein Binding Glycerol Transmembrane Transporter Activity Water Channel Activity Channel Activity
	Biological Process	Monoatomic Ion Transport Monoatomic Ion Transmembrane Transport Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Programmed Cell Death Cellular Response To Gamma Radiation Monoatomic Cation Transmembrane Transport	Renal Water Homeostasis Renal Water Transport Water Transport Actin Filament Organization Glycerol Transmembrane Transport Cellular Response To Water Deprivation Protein Homotetramerization Transmembrane Transport Cellular Response To Copper Ion Cellular Response To Mercury Ion Metanephric Collecting Duct Development
Pathways			Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins
Drugs
Diseases			Congenital nephrogenic diabetes insipidus (NDI)
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Obsessive-compulsive disorder ( 22889921)
Interacting Genes		16 interacting genes: AQP2 AQP9 ERGIC3 GOLM1 GPX8 LMNA MGST3 MTIF3 PDZK1IP1 RNF170 SAR1A SLC18A2 SPINT1 STOM TMEM52B TMEM80	60 interacting genes: ACTB ARLN BCAP31 CCDC167 CDIPT CERT1 CLCA4 CLDN7 CREB3 CREB3L1 CTSA CXCL16 EEF1A1 EFNA5 ELL2 ERG28 ERGIC3 ERMP1 FAM209A GPAA1 GPX8 IER3 IGFBP5 INSIG2 LEUTX LHFPL5 MRM1 MS4A13 MUC1 NDFIP2 OLFM4 OR10AG1 PANX1 PDZK1IP1 PLP2 PNLIPRP1 RTP2 SLC26A6 SLC30A2 SLC38A7 SLC5A2 SNAP47 SNX5 SPCS1 SSR3 STUB1 STX8 SUPT20H TM9SF2 TMEM109 TMEM218 TMEM230 TMEM236 TMEM60 TMEM86A TMEM97 TRARG1 UBE2J1 VAPB YIPF6
Entrez ID		79073	359
HPRD ID		14687	00141
Ensembl ID		ENSG00000110108	ENSG00000167580
Uniprot IDs		Q9BVC6	P41181
PDB IDs			4NEF 4OJ2 6QF5 8GCL 8GHJ 8OEE 8VVX
Enriched GO Terms of Interacting Partners?		Polyol Transmembrane Transport Glycerol Transmembrane Transport Amine Transport Water Channel Activity Membrane Glutathione Peroxidase Activity Water Transport Organic Hydroxy Compound Transport Fluid Transport Carbohydrate Transport Carbohydrate Transmembrane Transport Channel Activity Pyrimidine Nucleobase Transmembrane Transporter Activity Detoxification Of Arsenic-containing Substance Serotonin Secretion By Mast Cell Somato-dendritic Dopamine Secretion Transport Vesicle Membrane Lumenal Side Of Membrane Glycerol Transmembrane Transporter Activity DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Aminergic Neurotransmitter Loading Into Synaptic Vesicle Retrograde Transporter Complex, Golgi To ER Amino Acid Sensor Activity Mitochondrial Translational Initiation Cellular Response To Mercury Ion Cellular Response To Water Deprivation Purine Nucleobase Transmembrane Transporter Activity Urea Channel Activity Hydrogen Peroxide Channel Activity Cellular Oxidant Detoxification Histamine Uptake Serotonin:sodium:chloride Symporter Activity	Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Unfolded Protein Response Cellular Localization Intracellular Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Regulation Of Cellular Response To Stress Establishment Of Localization In Cell Regulation Of Chaperone-mediated Autophagy Regulation Of Response To Endoplasmic Reticulum Stress COPII-coated ER To Golgi Transport Vesicle Regulation Of Cellular Localization Host-mediated Activation Of Viral Genome Replication Carbohydrate Transmembrane Transport
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