TMEM109 and STOM

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM109	STOM
Description		transmembrane protein 109	stomatin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Sarcoplasmic Reticulum Membrane Monoatomic Ion Channel Complex Extracellular Exosome	Extracellular Space Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Cytoskeleton Plasma Membrane Membrane Cytoplasmic Vesicle Vesicle Azurophil Granule Membrane Specific Granule Membrane Melanosome Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome Tertiary Granule Membrane Blood Microparticle
	Molecular Function	Protein Binding Voltage-gated Monoatomic Cation Channel Activity	Protein Binding Ion Channel Inhibitor Activity Identical Protein Binding Protein Homodimerization Activity RNA Polymerase Binding
	Biological Process	Monoatomic Ion Transport Monoatomic Ion Transmembrane Transport Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Programmed Cell Death Cellular Response To Gamma Radiation Monoatomic Cation Transmembrane Transport	Regulation Of Monoatomic Ion Transmembrane Transport Host-mediated Activation Of Viral Genome Replication Positive Regulation Of Viral Process Positive Regulation Of Protein Targeting To Membrane
Pathways			Stimuli-sensing channels Neutrophil degranulation RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle
Drugs
Diseases			Hereditary stomatocytosis (HSt); Dehydrated hereditary stomatocytosis (DHS); Overhydrated hereditary stomatocytosis (OHS); Familial pseudohyperkalemia (FP)
GWAS
Interacting Genes		16 interacting genes: AQP2 AQP9 ERGIC3 GOLM1 GPX8 LMNA MGST3 MTIF3 PDZK1IP1 RNF170 SAR1A SLC18A2 SPINT1 STOM TMEM52B TMEM80	81 interacting genes: AIG1 APOA2 ASIC1 ASIC2 ASIC3 ATP1B3 ATP6V0B ATP6V0C BCL2L2 BNIP1 C2 C3orf52 CFHR5 CHST1 CLDN19 CLRN2 CMTM5 CNIH3 CTXN3 CYB5B CYB5R3 DAGLA DVL3 EMP1 ERG28 FAXDC2 FUNDC2 GIMAP1 GIMAP5 GPR25 GPR37L1 GRM2 HMOX2 KCNK1 KTN1 LANCL1 LNPEP MGLL MMP14 NKG7 ORMDL1 PEDS1-UBE2V1 PEMT PGA4 PMP22 PTCH1 RPL13A RPRM RTP2 RUVBL1 RUVBL2 SCD SELENOK SERP2 SFT2D1 SFT2D2 SFXN1 SFXN5 SLC2A1 SLC35B4 SMCO4 STX6 TECR THSD7B TMEM109 TMEM120B TMEM140 TMEM14B TMEM203 TMEM208 TMEM254 TMEM60 TMEM86B TMEM98 TMPO TNF TNFRSF10C TSPO2 VAMP4 WFDC2 YIPF6
Entrez ID		79073	2040
HPRD ID		14687	00585
Ensembl ID		ENSG00000110108	ENSG00000148175
Uniprot IDs		Q9BVC6	F8VSL7 P27105
PDB IDs			7WH3
Enriched GO Terms of Interacting Partners?		Polyol Transmembrane Transport Glycerol Transmembrane Transport Amine Transport Water Channel Activity Membrane Glutathione Peroxidase Activity Water Transport Organic Hydroxy Compound Transport Fluid Transport Carbohydrate Transport Carbohydrate Transmembrane Transport Channel Activity Pyrimidine Nucleobase Transmembrane Transporter Activity Detoxification Of Arsenic-containing Substance Serotonin Secretion By Mast Cell Somato-dendritic Dopamine Secretion Transport Vesicle Membrane Lumenal Side Of Membrane Glycerol Transmembrane Transporter Activity DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Aminergic Neurotransmitter Loading Into Synaptic Vesicle Retrograde Transporter Complex, Golgi To ER Amino Acid Sensor Activity Mitochondrial Translational Initiation Cellular Response To Mercury Ion Cellular Response To Water Deprivation Purine Nucleobase Transmembrane Transporter Activity Urea Channel Activity Hydrogen Peroxide Channel Activity Cellular Oxidant Detoxification Histamine Uptake Serotonin:sodium:chloride Symporter Activity	Membrane Endoplasmic Reticulum Membrane Sensory Perception Of Sour Taste Endoplasmic Reticulum Response To Acidic PH Sodium Channel Activity PH-gated Sodium Channel Activity Monoatomic Ion-gated Channel Activity Ligand-gated Sodium Channel Activity Protein Binding Cellular Response To Type II Interferon Response To PH PH-gated Monoatomic Ion Channel Activity Nitric-oxide Synthase Complex Synaptic Vesicle To Endosome Fusion Mitochondrial Outer Membrane Response To Type II Interferon Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Nitrite Reductase (NO-forming) Activity R2TP Complex Cellular Response To PH Detection Of Mechanical Stimulus Involved In Sensory Perception Acylglycerol Catabolic Process Diacylglycerol Catabolic Process Lipid Biosynthetic Process Amino Acid Transport Organic Anion Transport Telomerase RNA Localization To Cajal Body Sensory Perception Of Taste Response To Mechanical Stimulus Plasma Membrane
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