MIS12 and CBX3

Number of citations of the paper that reports this interaction (PMID 15502821)
80

Data Source:
HPRD (in vitro, in vivo)

		MIS12	CBX3
Gene Name		MIS12 kinetochore complex component	chromobox homolog 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	MIS12/MIND Type Complex Nucleus Cytosol	Condensed Chromosome, Centromeric Region Chromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Nuclear Euchromatin Nuclear Heterochromatin Spindle Nuclear Pericentric Heterochromatin
	Molecular Function	Protein Binding	Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Methyltransferase Binding
	Biological Process	Mitotic Cell Cycle Chromosome Segregation Mitotic Nuclear Division Cell Division Kinetochore Assembly	Chromatin Remodeling Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Rhythmic Process
Pathways		Mitotic Prometaphase Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Mitotic Anaphase Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: CASC5 CBX3 CBX5 DSN1 HSP90AA1 NDC80 NSL1 PMF1 SUGT1 ZWINT	32 interactors: ARL5A ATXN7L2 AURKA AURKB CACNB4 CBX1 CBX5 DNMT3B DSN1 H3F3A HIST1H1E HIST1H3A HIST1H4A HIST3H3 KLF11 L3MBTL1 L3MBTL2 LBR MGA MIS12 MKI67 NIPBL NSL1 PIM1 SP100 TAF4 TRIM24 TRIM28 VHL WHSC1L1 ZNF10 ZNF496
Entrez ID		79003	11335
HPRD ID		12379	05130
Ensembl ID		ENSG00000167842	ENSG00000122565
Uniprot IDs		A8K1M4 Q9H081	A4D177 B8ZZ43 Q13185
PDB IDs			2L11 3DM1 3KUP 3TZD
Enriched GO Terms of Interacting Partners?		Mitotic Nuclear Division Mitotic Cell Cycle Process Mitotic Cell Cycle Chromosome Segregation Cell Cycle Process Cell Cycle Cell Division Organelle Organization Attachment Of Spindle Microtubules To Kinetochore Chromosome Organization Microtubule Anchoring Mitotic Sister Chromatid Segregation Sister Chromatid Segregation Maintenance Of Protein Location In Cell Protein Import Into Mitochondrial Outer Membrane Chromatin Modification Maintenance Of Protein Location Maintenance Of Location In Cell Attachment Of Mitotic Spindle Microtubules To Kinetochore Chromatin Remodeling Chromatin Organization Protein Localization To Kinetochore Cell Cycle Checkpoint Protein Localization To Chromosome, Centromeric Region Histone H4-K5 Acetylation Histone H4-K8 Acetylation Chaperone-mediated Protein Complex Assembly Histone H4-K16 Acetylation Acrosome Assembly	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromosome Organization Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Chromatin Organization Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated DNA Methylation On Cytosine Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process DNA Methylation Regulation Of Nitrogen Compound Metabolic Process Chromatin Modification Organelle Organization DNA Modification Chromatin Silencing Mitotic Cell Cycle Chromatin Silencing At RDNA Mitotic Cell Cycle Process Protein-DNA Complex Assembly Mitotic Nuclear Division Negative Regulation Of Gene Expression, Epigenetic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Gene Expression Regulation Of Gene Expression, Epigenetic Protein Autophosphorylation Nucleobase-containing Compound Metabolic Process Spindle Stabilization Gene Silencing Chromosome Segregation Methylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleosome Assembly Nitrogen Compound Metabolic Process Chromatin Assembly Cellular Nitrogen Compound Metabolic Process Protein Complex Assembly Nucleosome Organization Cell Cycle Process Chromatin Assembly Or Disassembly DNA Replication-dependent Nucleosome Assembly Transcription, DNA-templated DNA Packaging
Tagcloud ?		assembled ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mitosis ndc80 orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus	1gamma actively assembled biogenesis deformed depleted dnmt3a h3k27 h3k9 heterochromatin hp1gamma linker npm1 nucleolar nucleoli nucleolus organization organized organizer perinucleolar rdna repetitive repressive ribosome silver striking tethering trimethylated u1242mg
Tagcloud (Difference) ?		ccan cenh3 cenp centromere centromeres centromeric continues deposition egg entails exit immunoprecipitate interphase kinetochore kinetochores mitosis ndc80 orchestrate precedes propagation reconstituted segregation sixteen soon spite vertebrate w xenopus	1gamma actively biogenesis deformed depleted dnmt3a h3k27 h3k9 heterochromatin hp1gamma linker npm1 nucleolar nucleoli nucleolus organization organized organizer perinucleolar rdna repetitive repressive ribosome silver striking tethering trimethylated u1242mg
Tagcloud (Intersection) ?		assembled