SCG2 and ATRIP

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SCG2	ATRIP
Description		secretogranin II	ATR interacting protein
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Secretory Granule Dense Core Granule Neuronal Dense Core Vesicle	Nucleus Nucleoplasm ATR-ATRIP Complex
	Molecular Function	Cytokine Activity Protein Binding Chemoattractant Activity	Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	MAPK Cascade Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Inflammatory Response Protein Secretion Intracellular Signal Transduction Endothelial Cell Migration Eosinophil Chemotaxis Positive Chemotaxis Induction Of Positive Chemotaxis Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	DNA Damage Checkpoint Signaling Nucleobase-containing Compound Metabolic Process DNA Repair DNA Damage Response Regulation Of Double-strand Break Repair
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Impaired BRCA2 binding to RAD51
Drugs
Diseases
GWAS		Airway wall thickness ( 25517131) Depression in smokers ( 30219690) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Fasting plasma glucose ( 32902719) Night sleep phenotypes ( 27126917) Osteoporosis-related phenotypes ( 20200953) Recurrent major depressive disorder x sex interaction ( 34099189) Response to hepatitis C treatment ( 22095909) Sodium levels ( 29403010) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		5 interacting genes: ATRIP NRIP1 TUBB4B UBQLN1 UBQLN4	28 interacting genes: BRCA1 C1orf94 CCDC28B CDC23 CDC6 CDK16 CEP164 CINP ETAA1 FAAP100 FAM156A LNX1 MCM2 MCM3 MCM5 MCM6 METTL21A MID2 MOS MX2 POLR1C PRKDC RPA3 SCG2 SIRT2 SPRY2 TASOR2 ZBTB14
Entrez ID		7857	84126
HPRD ID		06762
Ensembl ID		ENSG00000171951	ENSG00000164053
Uniprot IDs		P13521	Q8WXE1
PDB IDs			4IGK 4NB3 5YZ0 7XV4
Enriched GO Terms of Interacting Partners?		Polyubiquitin Modification-dependent Protein Binding Ovarian Follicle Rupture Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Cellular Response To Stress Autophagosome Nuclear Proteasome Complex ATR-ATRIP Complex Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Autophagosome Maturation Regulation Of Double-strand Break Repair Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macroautophagy Cytosolic Proteasome Complex Regulation Of DNA Repair Autophagy K48-linked Polyubiquitin Modification-dependent Protein Binding Nuclear Retinoid X Receptor Binding Ovulation Nuclear Glucocorticoid Receptor Binding Nuclear Retinoic Acid Receptor Binding MHC Class I Protein Binding Response To Stress Aggrephagy Positive Regulation Of ERAD Pathway Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Autophagy Regulation Of Autophagosome Maturation	DNA Metabolic Process DNA Repair DNA Replication Initiation Double-strand Break Repair Via Homologous Recombination CMG Complex MCM Complex Recombinational Repair DNA Replication Double-strand Break Repair Via Break-induced Replication Regulation Of DNA-templated DNA Replication Initiation DNA Damage Response Double-strand Break Repair DNA Recombination Chromosome, Telomeric Region Regulation Of Cell Cycle Phase Transition Single-stranded DNA Binding Regulation Of DNA Replication DNA Replication Origin Binding Cellular Response To Stress Single-stranded DNA Helicase Activity Regulation Of Cell Cycle Nucleic Acid Metabolic Process Regulation Of DNA Metabolic Process Regulation Of Mitotic Cell Cycle Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Mitotic DNA Replication Initiation Regulation Of Cell Cycle Process Response To Stress Negative Regulation Of Cell Cycle Phase Transition Helicase Activity Regulation Of Chromosome Segregation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Mitotic G2/M Transition Checkpoint Nucleoplasm Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Meiotic Cell Cycle 3'-5' DNA Helicase Activity Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Regulation Of Exit From Mitosis Negative Regulation Of Mitotic Cell Cycle Regulation Of Protein Phosphorylation Negative Regulation Of Fatty Acid Biosynthetic Process Regulation Of Phosphorylation Regulation Of DNA Damage Checkpoint Nucleolus
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