MALL and SIGLEC6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MALL	SIGLEC6
Description		mal, T cell differentiation protein like	sialic acid binding Ig like lectin 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Plasma Membrane Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Raft	Extracellular Region Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding Structural Constituent Of Myelin Sheath	Protein Binding Carbohydrate Binding Sialic Acid Binding
	Biological Process	Myelination Cholesterol Homeostasis	Cell Adhesion Cell-cell Signaling
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Carotid intima media thickness ( 26343869)
Interacting Genes		69 interacting genes: AMIGO1 AQP6 ARL13B ATP5PF BEST2 BNIP3 BNIP3L BRI3 BSCL2 CAV1 CAV2 CD79A CLDN7 CLDN9 CLEC10A CLEC12B CLEC14A CPLX4 CREB3 CREB3L1 CRHR2 CTLA4 DAGLA DCBLD2 ELOVL2 ELOVL4 EMP1 ERGIC3 EVI2A FCGR1A FFAR2 FNDC9 GGT7 GJA8 GPA33 IL7R KASH5 KLRC1 LDLRAD1 LEPROTL1 LMNA MANBAL MCEMP1 MS4A12 MSR1 MUC1 OPRM1 PGRMC2 PLA2G2E RETREG3 RNF185 SIGLEC6 SIT1 SLC10A1 SLC10A6 SLC18A1 SLC35H1 STMN4 STX1A SYNE4 SYT2 TMEM139 TMEM182 TMEM248 TMEM31 TMEM80 TMX2 UBE2I ZP3	7 interacting genes: FHL2 LEP LGALS3BP MALL PAX6 TCF4 ZNF655
Entrez ID		7851	946
HPRD ID		15997	16058
Ensembl ID		ENSG00000144063	ENSG00000105492
Uniprot IDs		Q13021	O43699
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Caveolar Macromolecular Signaling Complex Nuclear Envelope Adaptive Immune Response Natural Killer Cell Inhibitory Signaling Pathway Endoplasmic Reticulum-autophagosome Adaptor Activity Carbohydrate Binding External Side Of Plasma Membrane Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Acute Inflammatory Response Bile Acid:sodium Symporter Activity Membrane Organization Immune Response-regulating Signaling Pathway Lipid Storage Positive Regulation Of Hypersensitivity Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Substrate Localization To Autophagosome Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Fatty Acid Elongation, Saturated Fatty Acid Mitochondrial Outer Membrane Permeabilization Caveola Assembly Organic Hydroxy Compound Transport Regulation Of Response To Endoplasmic Reticulum Stress Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Regulation Of Calcium Ion-dependent Exocytosis Mitochondrial Protein Catabolic Process Plasma Membrane Raft Assembly Negative Regulation Of T Cell Mediated Cytotoxicity Meiotic Nuclear Membrane Microtubule Tethering Complex Regulation Of Acute Inflammatory Response Immune Response-inhibiting Signal Transduction	Atrial Cardiac Muscle Cell Development Regulation Of Transcription By RNA Polymerase II Elastin Metabolic Process Carbohydrate Homeostasis Leptin Receptor Binding Activation Of Protein Kinase C Activity Regulation Of Lipoprotein Lipid Oxidation Glucose Homeostasis Positive Regulation Of Fat Cell Apoptotic Process Positive Regulation Of Luteinizing Hormone Secretion Blood Vessel Development Regulation Of Follicle-stimulating Hormone Secretion Bone Mineralization Involved In Bone Maturation Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Follicle-stimulating Hormone Secretion Cellular Response To L-ascorbic Acid Positive Regulation Of Hepatic Stellate Cell Activation Response To Vitamin E Prostaglandin Secretion Response To L-ascorbic Acid Regulation Of Fat Cell Apoptotic Process Regulation Of Glucagon Secretion Regulation Of Intestinal Cholesterol Absorption Neuron Development Glycerol Biosynthetic Process Negative Regulation Of Glucagon Secretion Negative Regulation Of Glutamine Transport Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Forebrain Dorsal/ventral Pattern Formation Regulation Of Asymmetric Cell Division Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Habenula Development Oligodendrocyte Cell Fate Specification Pallium Development Formation Of Anatomical Boundary Glial Cell Fate Specification Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Regulation Of Neuron Differentiation Cerebral Cortex Regionalization Lacrimal Gland Development Telencephalon Regionalization TFIIB-class Transcription Factor Binding Beta-catenin-TCF7L2 Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Anatomical Structure Formation Involved In Morphogenesis Forebrain Neuron Fate Commitment Ventral Spinal Cord Development Iris Morphogenesis
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