MALL and CRHR2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MALL	CRHR2
Description		mal, T cell differentiation protein like	corticotropin releasing hormone receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Plasma Membrane Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Raft	Plasma Membrane Membrane Dendrite Axon Terminus
	Molecular Function	Protein Binding Structural Constituent Of Myelin Sheath	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Corticotrophin-releasing Factor Receptor Activity Peptide Hormone Binding Corticotropin-releasing Hormone Receptor Activity
	Biological Process	Myelination Cholesterol Homeostasis	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Hormone-mediated Signaling Pathway Long-term Synaptic Potentiation Cellular Response To Corticotropin-releasing Hormone Stimulus
Pathways			G alpha (s) signalling events Synthesis, secretion, and deacylation of Ghrelin
Drugs
Diseases
GWAS			Type 2 diabetes ( 24509480 30297969)
Interacting Genes		69 interacting genes: AMIGO1 AQP6 ARL13B ATP5PF BEST2 BNIP3 BNIP3L BRI3 BSCL2 CAV1 CAV2 CD79A CLDN7 CLDN9 CLEC10A CLEC12B CLEC14A CPLX4 CREB3 CREB3L1 CRHR2 CTLA4 DAGLA DCBLD2 ELOVL2 ELOVL4 EMP1 ERGIC3 EVI2A FCGR1A FFAR2 FNDC9 GGT7 GJA8 GPA33 IL7R KASH5 KLRC1 LDLRAD1 LEPROTL1 LMNA MANBAL MCEMP1 MS4A12 MSR1 MUC1 OPRM1 PGRMC2 PLA2G2E RETREG3 RNF185 SIGLEC6 SIT1 SLC10A1 SLC10A6 SLC18A1 SLC35H1 STMN4 STX1A SYNE4 SYT2 TMEM139 TMEM182 TMEM248 TMEM31 TMEM80 TMX2 UBE2I ZP3	7 interacting genes: APP CRH GPR35 MALL UCN UCN2 UCN3
Entrez ID		7851	1395
HPRD ID		15997	03614
Ensembl ID		ENSG00000144063	ENSG00000106113
Uniprot IDs		Q13021	A0A090N7T4 Q13324
PDB IDs			3N93 3N95 3N96 6PB1 7TRY 7TS0
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Caveolar Macromolecular Signaling Complex Nuclear Envelope Adaptive Immune Response Natural Killer Cell Inhibitory Signaling Pathway Endoplasmic Reticulum-autophagosome Adaptor Activity Carbohydrate Binding External Side Of Plasma Membrane Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Acute Inflammatory Response Bile Acid:sodium Symporter Activity Membrane Organization Immune Response-regulating Signaling Pathway Lipid Storage Positive Regulation Of Hypersensitivity Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Substrate Localization To Autophagosome Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Fatty Acid Elongation, Saturated Fatty Acid Mitochondrial Outer Membrane Permeabilization Caveola Assembly Organic Hydroxy Compound Transport Regulation Of Response To Endoplasmic Reticulum Stress Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Regulation Of Calcium Ion-dependent Exocytosis Mitochondrial Protein Catabolic Process Plasma Membrane Raft Assembly Negative Regulation Of T Cell Mediated Cytotoxicity Meiotic Nuclear Membrane Microtubule Tethering Complex Regulation Of Acute Inflammatory Response Immune Response-inhibiting Signal Transduction	Corticotropin-releasing Hormone Receptor 2 Binding Varicosity Positive Regulation Of CAMP/PKA Signal Transduction Hormone Activity Corticotropin-releasing Hormone Receptor Binding Regulation Of CAMP/PKA Signal Transduction Corticotropin-releasing Hormone Receptor 1 Binding Regulation Of Calcium Ion Transport Positive Regulation Of Corticotropin Secretion G Protein-coupled Receptor Binding Positive Regulation Of Behavioral Fear Response Regulation Of Corticotropin Secretion Positive Regulation Of Fear Response Associative Learning G Protein-coupled Receptor Signaling Pathway Regulation Of Metal Ion Transport Regulation Of Behavioral Fear Response Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Signaling Receptor Binding Regulation Of Monoatomic Ion Transport Response To Corticosterone Response To Glucocorticoid Response To Pain Perikaryon Hormone-mediated Signaling Pathway Positive Regulation Of Hormone Secretion Response To Auditory Stimulus Response To Corticosteroid Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Learning Response To Immobilization Stress Positive Regulation Of Calcium Ion Import Positive Regulation Of Behavior Digestion Neuropeptide Hormone Activity Regulation Of Peptide Hormone Secretion Response To Steroid Hormone Response To Mineralocorticoid Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Transport Regulation Of Hormone Secretion Regulation Of Calcium Ion Import Negative Regulation Of Blood Pressure Learning Or Memory Positive Regulation Of Secretion By Cell Regulation Of Transport Axon Terminus Cognition Positive Regulation Of Establishment Of Protein Localization
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