MALL and CAV2

Number of citations of the paper that reports this interaction (PubMedID 11294831)
0

Data Source:
HPRD (in vitro, in vivo)

		MALL	CAV2
Description		mal, T cell differentiation protein like	caveolin 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Plasma Membrane Membrane Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Raft	Golgi Membrane Acrosomal Membrane Caveolar Macromolecular Signaling Complex Nucleus Cytoplasm Golgi Apparatus Plasma Membrane Caveola Focal Adhesion Membrane Transport Vesicle Cytoplasmic Vesicle Protein-containing Complex Plasma Membrane Raft Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Structural Constituent Of Myelin Sheath	Protein Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity D1 Dopamine Receptor Binding Heterotrimeric G-protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Molecular Adaptor Activity Scaffold Protein Binding
	Biological Process	Myelination Cholesterol Homeostasis	Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Vesicle Fusion Mitochondrion Organization Endoplasmic Reticulum Organization Regulation Of Mitotic Nuclear Division Transforming Growth Factor Beta Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell Population Proliferation Insulin Receptor Signaling Pathway Skeletal Muscle Cell Proliferation Negative Regulation Of Skeletal Muscle Cell Proliferation Vesicle Organization Receptor-mediated Endocytosis Of Virus By Host Cell Viral Release From Host Cell Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Host-mediated Activation Of Viral Process Vesicle Docking Skeletal Muscle Fiber Development Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Dopamine Receptor Signaling Pathway Caveola Assembly Basement Membrane Organization
Pathways			Extra-nuclear estrogen signaling
Drugs
Diseases
GWAS			Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Atrial fibrillation ( 33990960 30061737 29892015) Glaucoma ( 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 20835238 33627673 29891935 25173105) Heart rate increase in response to exercise ( 29497042) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Intraocular pressure ( 30054594 31959993 25173106 31798171 28073927 29785010 29617998) P wave duration ( 28794112) Pancreatic ductal adenocarcinoma ( 33975060) PR interval ( 29127183 30046033 32439900 25035420 20062060) Refractive error ( 32231278) TPE interval (resting) ( 32386560)
Interacting Genes		69 interacting genes: AMIGO1 AQP6 ARL13B ATP5PF BEST2 BNIP3 BNIP3L BRI3 BSCL2 CAV1 CAV2 CD79A CLDN7 CLDN9 CLEC10A CLEC12B CLEC14A CPLX4 CREB3 CREB3L1 CRHR2 CTLA4 DAGLA DCBLD2 ELOVL2 ELOVL4 EMP1 ERGIC3 EVI2A FCGR1A FFAR2 FNDC9 GGT7 GJA8 GPA33 IL7R KASH5 KLRC1 LDLRAD1 LEPROTL1 LMNA MANBAL MCEMP1 MS4A12 MSR1 MUC1 OPRM1 PGRMC2 PLA2G2E RETREG3 RNF185 SIGLEC6 SIT1 SLC10A1 SLC10A6 SLC18A1 SLC35H1 STMN4 STX1A SYNE4 SYT2 TMEM139 TMEM182 TMEM248 TMEM31 TMEM80 TMX2 UBE2I ZP3	13 interacting genes: CAV1 CSNK2A1 DNAJA1 DRD1 EGFR FLOT2 GOLGB1 MALL NCK1 RASA1 SDCBP SNCA SRC
Entrez ID		7851	858
HPRD ID		15997	03029
Ensembl ID		ENSG00000144063	ENSG00000105971
Uniprot IDs		Q13021	P51636 Q53X57
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Caveolar Macromolecular Signaling Complex Nuclear Envelope Adaptive Immune Response Natural Killer Cell Inhibitory Signaling Pathway Endoplasmic Reticulum-autophagosome Adaptor Activity Carbohydrate Binding External Side Of Plasma Membrane Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Acute Inflammatory Response Bile Acid:sodium Symporter Activity Membrane Organization Immune Response-regulating Signaling Pathway Lipid Storage Positive Regulation Of Hypersensitivity Fatty Acid Elongation, Monounsaturated Fatty Acid Fatty Acid Elongase Activity Fatty Acid Elongation, Polyunsaturated Fatty Acid Substrate Localization To Autophagosome Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Fatty Acid Elongation, Saturated Fatty Acid Mitochondrial Outer Membrane Permeabilization Caveola Assembly Organic Hydroxy Compound Transport Regulation Of Response To Endoplasmic Reticulum Stress Immune Response-inhibiting Cell Surface Receptor Signaling Pathway Regulation Of Calcium Ion-dependent Exocytosis Mitochondrial Protein Catabolic Process Plasma Membrane Raft Assembly Negative Regulation Of T Cell Mediated Cytotoxicity Meiotic Nuclear Membrane Microtubule Tethering Complex Regulation Of Acute Inflammatory Response Immune Response-inhibiting Signal Transduction	Membrane Raft Protein Sequestering Activity Regulation Of Intracellular Signal Transduction Regulation Of MAPK Cascade Regulation Of Primary Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Protein Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Metabolic Process Protein Localization To Plasma Membrane Raft Negative Regulation Of Signaling Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Regulation Of Locomotion Perinuclear Region Of Cytoplasm Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway Ephrin Receptor Signaling Pathway Enzyme Binding Positive Regulation Of Intracellular Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Calcium Ion Transmembrane Transport Focal Adhesion Regulation Of Dopamine Uptake Involved In Synaptic Transmission Signal Complex Assembly Protein Localization To Membrane Raft Positive Regulation Of MAPK Cascade Caveola Substrate-dependent Cell Migration, Cell Extension Positive Regulation Of Cellular Component Biogenesis ATPase Binding Regulation Of RNA Metabolic Process Regulation Of Cellular Response To Stress Positive Regulation Of T Cell Activation Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Cell Migration Plasma Membrane Regulation Of Cell Migration Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To Growth Factor Stimulus
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