CRHR2 and UCN

Number of citations of the paper that reports this interaction (PMID 11416224)
149

Data Source:
HPRD (in vivo, in vitro)

		CRHR2	UCN
Gene Name		corticotropin releasing hormone receptor 2	urocortin
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface	Extracellular Region Dendrite Varicosity Perikaryon Axon Terminus
	Molecular Function	Hormone Activity Protein Binding Corticotrophin-releasing Factor Receptor Activity	Neuropeptide Hormone Activity Protein Binding Histone Deacetylase Inhibitor Activity Corticotropin-releasing Hormone Receptor 1 Binding Corticotropin-releasing Hormone Receptor 2 Binding
	Biological Process	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Angiogenesis Positive Regulation Of CAMP-mediated Signaling Negative Regulation Of CAMP-mediated Signaling Cellular Response To Corticotropin-releasing Hormone Stimulus	Inflammatory Response Response To Oxidative Stress G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Sensory Perception Of Sound Associative Learning Aerobic Respiration Negative Regulation Of Gene Expression Pancreatic Juice Secretion Positive Regulation Of Cell Growth Positive Regulation Of CAMP Biosynthetic Process Negative Regulation Of Histone Deacetylation Neuron Projection Development Negative Regulation Of Appetite Response To Estradiol Positive Regulation Of Interleukin-6 Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Activation Of Protein Kinase A Activity Social Behavior Gastric Emptying Drinking Behavior Negative Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Positive Regulation Of Translation Positive Regulation Of DNA Replication Negative Regulation Of Blood Pressure Negative Regulation Of Cell Size Positive Regulation Of Vasodilation Negative Regulation Of Hormone Secretion Response To Pain Response To Glucocorticoid Positive Regulation Of Corticotropin Secretion Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Gastric Acid Secretion Negative Regulation Of Necrotic Cell Death Positive Regulation Of Calcium Ion Import Negative Regulation Of Neuron Death Negative Regulation Of Feeding Behavior Positive Regulation Of Behavioral Fear Response
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS			Crohn's disease ( 23128233)
Protein-Protein Interactions		5 interactors: APP CRH UCN UCN2 UCN3	4 interactors: CRHBP CRHR1 CRHR2 LEP
Entrez ID		1395	7349
HPRD ID		03614	02970
Ensembl ID
Uniprot IDs		B2R967 B3SXS6 B3SXT0 Q13324	P55089
PDB IDs		3N93 3N95 3N96	2RMF 3N96
Enriched GO Terms of Interacting Partners?		Response To Immobilization Stress Response To Glucocorticoid Response To Corticosteroid Regulation Of Hormone Secretion Positive Regulation Of Corticotropin Secretion Negative Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Hormone Secretion Regulation Of Corticotropin Secretion Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Associative Learning Feeding Behavior Positive Regulation Of Behavioral Fear Response Negative Regulation Of Gonadotropin Secretion Response To Steroid Hormone Positive Regulation Of Hormone Secretion Digestion Learning Regulation Of Secretion Positive Regulation Of Calcium Ion Import Negative Regulation Of Secretion By Cell Negative Regulation Of Secretion Regulation Of Peptide Hormone Secretion Response To Lipid Regulation Of Calcium Ion Import Response To Organic Cyclic Compound Response To Hormone Learning Or Memory Regulation Of Cellular Localization Cognition Response To Corticosterone Response To Abiotic Stimulus Positive Regulation Of Secretion Response To Mineralocorticoid Response To Pain Regulation Of Signaling Negative Regulation Of Blood Pressure Negative Regulation Of Transport Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Response To Nutrient Levels Positive Regulation Of CAMP Biosynthetic Process Single-organism Behavior Response To Stress Response To Extracellular Stimulus Positive Regulation Of Insulin Secretion Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Cyclic Nucleotide Metabolic Process	Cellular Response To Corticotropin-releasing Hormone Stimulus Negative Regulation Of Hormone Secretion Response To Peptide Hormone Response To Peptide Cellular Response To Hormone Stimulus Negative Regulation Of Secretion By Cell Adult Behavior Behavioral Response To Ethanol Response To Organonitrogen Compound Negative Regulation Of Secretion Response To Hormone Female Pregnancy Regulation Of Hormone Secretion Regulation Of Hormone Levels Negative Regulation Of Signaling Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Negative Regulation Of Transport Negative Regulation Of Peptide Secretion Response To Cocaine Single-organism Behavior Cellular Response To Organonitrogen Compound Secretion By Cell Cellular Response To Organic Substance Peptide Hormone Secretion Peptide Secretion Behavior Regulation Of Ion Transport Secretion Hormone Secretion Regulation Of Secretion Hormone Transport Response To Ammonium Ion Regulation Of Lipid Transport Peptide Transport Negative Regulation Of Ion Transport Response To Organic Substance Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Corticotropin Secretion Cellular Response To L-ascorbic Acid Negative Regulation Of Corticotropin-releasing Hormone Receptor Activity Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Glutamine Transport General Adaptation Syndrome, Behavioral Process Amide Transport Hormone-mediated Signaling Pathway Response To Organic Cyclic Compound Response To Ethanol Regulation Of Ion Transmembrane Transporter Activity Cell-cell Signaling
Tagcloud ?		amygdala cns corticosterone corticotropin crf2 disparity drinking f2 gs inbred inp ip lowered maps minute nonpreferring np polymorphism preference preferring qtl releasing restraint screen trait ucns untranslated urocortins	agonists belonging cardioprotection cardiovascular congestive corticotropin crh exert gastrointestinal gpcr hormones inotropic lusitropic nervous r1 r2 releasing renin reperfusion reproductive restoration summarizes suppress sympathetic ucn1 ucn2 ucn3 urocortins vasodilation
Tagcloud (Difference) ?		amygdala cns corticosterone crf2 disparity drinking f2 gs inbred inp ip lowered maps minute nonpreferring np polymorphism preference preferring qtl restraint screen trait ucns untranslated	agonists belonging cardioprotection cardiovascular congestive exert gastrointestinal gpcr hormones inotropic lusitropic nervous r1 r2 renin reperfusion reproductive restoration summarizes suppress sympathetic ucn1 ucn2 ucn3 vasodilation
Tagcloud (Intersection) ?		corticotropin crh releasing urocortins