CRHR2 and UCN3

Number of citations of the paper that reports this interaction (PMID 11416224)
149

Data Source:
HPRD (two hybrid, in vitro)

		CRHR2	UCN3
Gene Name		corticotropin releasing hormone receptor 2	urocortin 3
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface	Extracellular Space Varicosity Axon Terminus
	Molecular Function	Hormone Activity Protein Binding Corticotrophin-releasing Factor Receptor Activity	G-protein Coupled Receptor Binding Hormone Activity Corticotropin-releasing Hormone Receptor 2 Binding
	Biological Process	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Angiogenesis Positive Regulation Of CAMP-mediated Signaling Negative Regulation Of CAMP-mediated Signaling Cellular Response To Corticotropin-releasing Hormone Stimulus	Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Digestion Response To Glucose Cellular Response To Nutrient Levels Positive Regulation Of Insulin Secretion Response To Immobilization Stress Response To Starvation Positive Regulation Of Membrane Potential Response To Corticosterone Cellular Response To Hypoxia
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS			Intelligence ( 22449649)
Protein-Protein Interactions		5 interactors: APP CRH UCN UCN2 UCN3	3 interactors: CRHR1 CRHR2 IL10RB
Entrez ID		1395	114131
HPRD ID		03614	12066
Ensembl ID			ENSG00000178473
Uniprot IDs		B2R967 B3SXS6 B3SXT0 Q13324	Q969E3
PDB IDs		3N93 3N95 3N96	2RMH 3N93
Enriched GO Terms of Interacting Partners?		Response To Immobilization Stress Response To Glucocorticoid Response To Corticosteroid Regulation Of Hormone Secretion Positive Regulation Of Corticotropin Secretion Negative Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Hormone Secretion Regulation Of Corticotropin Secretion Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Associative Learning Feeding Behavior Positive Regulation Of Behavioral Fear Response Negative Regulation Of Gonadotropin Secretion Response To Steroid Hormone Positive Regulation Of Hormone Secretion Digestion Learning Regulation Of Secretion Positive Regulation Of Calcium Ion Import Negative Regulation Of Secretion By Cell Negative Regulation Of Secretion Regulation Of Peptide Hormone Secretion Response To Lipid Regulation Of Calcium Ion Import Response To Organic Cyclic Compound Response To Hormone Learning Or Memory Regulation Of Cellular Localization Cognition Response To Corticosterone Response To Abiotic Stimulus Positive Regulation Of Secretion Response To Mineralocorticoid Response To Pain Regulation Of Signaling Negative Regulation Of Blood Pressure Negative Regulation Of Transport Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Response To Nutrient Levels Positive Regulation Of CAMP Biosynthetic Process Single-organism Behavior Response To Stress Response To Extracellular Stimulus Positive Regulation Of Insulin Secretion Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Cyclic Nucleotide Metabolic Process	Cellular Response To Corticotropin-releasing Hormone Stimulus Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger General Adaptation Syndrome, Behavioral Process Corticotropin Secretion General Adaptation Syndrome Cellular Response To Organic Substance Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Corticosterone Secretion Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Epinephrine Secretion Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Feeding Behavior Negative Regulation Of CAMP-mediated Signaling Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Response To Organic Substance Locomotory Exploration Behavior Behavioral Response To Ethanol Positive Regulation Of Mast Cell Degranulation Regulation Of Feeding Behavior Positive Regulation Of CAMP-mediated Signaling Behavioral Response To Cocaine Positive Regulation Of Mast Cell Activation Cellular Response To Hormone Stimulus Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Parturition Cell Surface Receptor Signaling Pathway Negative Regulation Of Cation Channel Activity Positive Regulation Of Regulated Secretory Pathway Regulation Of Voltage-gated Calcium Channel Activity Behavioral Response To Pain Regulation Of CAMP-mediated Signaling Response To Immobilization Stress Hypothalamus Development Regulation Of Mast Cell Degranulation Exploration Behavior Response To Organonitrogen Compound Activation Of Adenylate Cyclase Activity Positive Regulation Of Adenylate Cyclase Activity Regulation Of Mast Cell Activation Response To Hormone Regulation Of Regulated Secretory Pathway Adrenal Gland Development Response To Pain Fear Response Negative Regulation Of Transporter Activity
Tagcloud ?		amygdala cns corticosterone corticotropin crf2 disparity drinking f2 gs inbred inp ip lowered maps minute nonpreferring np polymorphism preference preferring qtl releasing restraint screen trait ucns untranslated urocortins	agonists belonging cardioprotection cardiovascular congestive corticotropin crh exert gastrointestinal gpcr hormones inotropic lusitropic nervous r1 r2 releasing renin reperfusion reproductive restoration summarizes suppress sympathetic ucn1 ucn2 urocortins vasodilation
Tagcloud (Difference) ?		amygdala cns corticosterone crf2 disparity drinking f2 gs inbred inp ip lowered maps minute nonpreferring np polymorphism preference preferring qtl restraint screen trait ucns untranslated	agonists belonging cardioprotection cardiovascular congestive exert gastrointestinal gpcr hormones inotropic lusitropic nervous r1 r2 renin reperfusion reproductive restoration summarizes suppress sympathetic ucn1 ucn2 vasodilation
Tagcloud (Intersection) ?		corticotropin crh releasing urocortins