CRHR2 and UCN2

Number of citations of the paper that reports this interaction (PMID 11416224)
149

Data Source:
HPRD (in vivo, in vitro)

		CRHR2	UCN2
Gene Name		corticotropin releasing hormone receptor 2	urocortin 2
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell Surface	Extracellular Region Extracellular Space
	Molecular Function	Hormone Activity Protein Binding Corticotrophin-releasing Factor Receptor Activity	G-protein Coupled Receptor Binding Receptor Binding Hormone Activity Hormone Binding Corticotropin-releasing Hormone Receptor 2 Binding
	Biological Process	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Angiogenesis Positive Regulation Of CAMP-mediated Signaling Negative Regulation Of CAMP-mediated Signaling Cellular Response To Corticotropin-releasing Hormone Stimulus	CAMP Biosynthetic Process Response To Stress Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Digestion Cell Proliferation Negative Regulation Of Gene Expression Cellular Response To Nutrient Levels Negative Regulation Of Luteinizing Hormone Secretion Response To Immobilization Stress Negative Regulation Of Follicle-stimulating Hormone Secretion Cellular Response To Glucocorticoid Stimulus Cellular Response To Hypoxia
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		5 interactors: APP CRH UCN UCN2 UCN3	2 interactors: CRHR2 IL10RB
Entrez ID		1395	90226
HPRD ID		03614	16171
Ensembl ID			ENSG00000145040
Uniprot IDs		B2R967 B3SXS6 B3SXT0 Q13324	Q96RP3
PDB IDs		3N93 3N95 3N96	2RMG 3N95
Enriched GO Terms of Interacting Partners?		Response To Immobilization Stress Response To Glucocorticoid Response To Corticosteroid Regulation Of Hormone Secretion Positive Regulation Of Corticotropin Secretion Negative Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Hormone Secretion Regulation Of Corticotropin Secretion Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Associative Learning Feeding Behavior Positive Regulation Of Behavioral Fear Response Negative Regulation Of Gonadotropin Secretion Response To Steroid Hormone Positive Regulation Of Hormone Secretion Digestion Learning Regulation Of Secretion Positive Regulation Of Calcium Ion Import Negative Regulation Of Secretion By Cell Negative Regulation Of Secretion Regulation Of Peptide Hormone Secretion Response To Lipid Regulation Of Calcium Ion Import Response To Organic Cyclic Compound Response To Hormone Learning Or Memory Regulation Of Cellular Localization Cognition Response To Corticosterone Response To Abiotic Stimulus Positive Regulation Of Secretion Response To Mineralocorticoid Response To Pain Regulation Of Signaling Negative Regulation Of Blood Pressure Negative Regulation Of Transport Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Response To Nutrient Levels Positive Regulation Of CAMP Biosynthetic Process Single-organism Behavior Response To Stress Response To Extracellular Stimulus Positive Regulation Of Insulin Secretion Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Cyclic Nucleotide Metabolic Process	Cellular Response To Corticotropin-releasing Hormone Stimulus Negative Regulation Of CAMP-mediated Signaling Positive Regulation Of CAMP-mediated Signaling Regulation Of CAMP-mediated Signaling
Tagcloud ?		amygdala cns corticosterone corticotropin crf2 disparity drinking f2 gs inbred inp ip lowered maps minute nonpreferring np polymorphism preference preferring qtl releasing restraint screen trait ucns untranslated urocortins	agonists belonging cardioprotection cardiovascular congestive corticotropin crh exert gastrointestinal gpcr hormones inotropic lusitropic nervous r1 r2 releasing renin reperfusion reproductive restoration summarizes suppress sympathetic ucn1 ucn3 urocortins vasodilation
Tagcloud (Difference) ?		amygdala cns corticosterone crf2 disparity drinking f2 gs inbred inp ip lowered maps minute nonpreferring np polymorphism preference preferring qtl restraint screen trait ucns untranslated	agonists belonging cardioprotection cardiovascular congestive exert gastrointestinal gpcr hormones inotropic lusitropic nervous r1 r2 renin reperfusion reproductive restoration summarizes suppress sympathetic ucn1 ucn3 vasodilation
Tagcloud (Intersection) ?		corticotropin crh releasing urocortins