CA4 and PRDX2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CA4	PRDX2
Description		carbonic anhydrase 4	peroxiredoxin 2
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GO Annotations	Cellular Component	Rough Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Trans-Golgi Network Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Secretory Granule Membrane Brush Border Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Side Of Membrane	Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Lyase Activity Metal Ion Binding	Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Peroxiredoxin Activity Thioredoxin-dependent Peroxiredoxin Activity
	Biological Process	Bicarbonate Transport	Defense Response To Tumor Cell Respiratory Burst Involved In Inflammatory Response Response To Oxidative Stress Regulation Of Hydrogen Peroxide Metabolic Process Removal Of Superoxide Radicals Positive Regulation Of Blood Coagulation Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Oxidative Stress T Cell Proliferation Hydrogen Peroxide Metabolic Process Hydrogen Peroxide Catabolic Process Regulation Of Apoptotic Process T Cell Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Leukocyte Activation Cell Redox Homeostasis Negative Regulation Of T Cell Differentiation Thymus Development Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Reversible hydration of carbon dioxide	Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs		Methyclothiazide Topiramate Ethoxzolamide Bendroflumethiazide Benzthiazide Benzthiazide Cyclothiazide Methazolamide Hydroflumethiazide Acetazolamide Dorzolamide Zonisamide Trichlormethiazide Diclofenamide Brinzolamide Ellagic acid Sodium carbonate	3-sulfino-L-alanine N-Carbamoyl-Alanine Copper
Diseases		Retinitis pigmentosa (RP)
GWAS			Platelet distribution width ( 32888494)
Interacting Genes		5 interacting genes: PIH1D1 PRDX2 SLC4A1 SLC4A3 SLC4A4	24 interacting genes: A2M APOE APP BAD CA4 CD320 CDC37 CDK1 COPS5 ECSIT EXOC6 IFIT5 MAST1 NLGN3 PDGFRB PPP2R1A PPP2R1B PSEN1 RNF32 RPL4 SAT1 SUMO4 TXNDC5 UTY
Entrez ID		762	7001
HPRD ID		00261	02763
Ensembl ID		ENSG00000167434	ENSG00000167815
Uniprot IDs		P22748	P32119 V9HW12
PDB IDs		1ZNC 3F7B 3F7U 3FW3 5IPZ 5JN8 5JN9 5JNA 5JNC 5KU6	1QMV 5B8A 5B8B 5IJT 7KIZ 7KJ0 7KJ1
Enriched GO Terms of Interacting Partners?		Monoatomic Anion Transmembrane Transporter Activity Solute:inorganic Anion Antiporter Activity Bicarbonate Transport Bicarbonate Transmembrane Transporter Activity Regulation Of Cellular PH Regulation Of Intracellular PH Regulation Of PH Chloride:bicarbonate Antiporter Activity Monoatomic Anion Transmembrane Transport Inorganic Anion Transport Monoatomic Anion Transport Cellular Homeostasis Organic Anion Transport Regulation Of Glycolytic Process Regulation Of Carbohydrate Catabolic Process Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Transport Across Blood-brain Barrier Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process PH Elevation Respiratory Burst Involved In Inflammatory Response Homeostatic Process Monoatomic Ion Homeostasis Regulation Of Biological Quality Monoatomic Cation Homeostasis Antiporter Activity Chloride Transmembrane Transport Intracellular Chemical Homeostasis Chloride Transport Inorganic Anion Transmembrane Transport Cellular Response To Triglyceride RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding TORC1 Complex Assembly Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Glucose Mediated Signaling Pathway Inorganic Ion Transmembrane Transport Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Response To Triglyceride Sodium:bicarbonate Symporter Activity Regulation Of Glucose Mediated Signaling Pathway Monoatomic Ion Transmembrane Transport Negative Regulation Of Urine Volume Hemoglobin Binding Thioredoxin-dependent Peroxiredoxin Activity Annulate Lamellae SnoRNA Localization R2TP Complex Peroxiredoxin Activity Thioredoxin Peroxidase Activity	Positive Regulation Of Amyloid Fibril Formation Regulation Of Amyloid Fibril Formation Lipoprotein Particle Regulation Of Protein Localization To Nucleus Astrocyte Activation Involved In Immune Response Meiotic Sister Chromatid Cohesion, Centromeric Intermediate-density Lipoprotein Particle Growth Factor Receptor Binding Rough Endoplasmic Reticulum Positive Regulation Of Protein Transport Positive Regulation Of Protein Localization Cellular Response To Amyloid-beta Positive Regulation Of Apoptotic Signaling Pathway Extracellular Exosome Positive Regulation Of Establishment Of Protein Localization Regulation Of Signal Transduction Positive Regulation Of Signaling Response To Amyloid-beta Regulation Of Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Meiotic Sister Chromatid Cohesion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Programmed Cell Death Regulation Of Dendritic Spine Maintenance Neuron Projection Maintenance Enzyme Binding Positive Regulation Of Proteolysis Low-density Lipoprotein Particle Regulation Of Protein Localization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Regulation Of Apoptotic Signaling Pathway Protein Phosphatase Type 2A Complex Regulation Of Immune System Process Positive Regulation Of Signal Transduction Heparan Sulfate Proteoglycan Binding Astrocyte Activation Negative Regulation Of DNA Binding Regulation Of Immune Response Regulation Of Innate Immune Response Very-low-density Lipoprotein Particle Regulation Of Amyloid-beta Clearance Regulation Of Protein Transport Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Protein Localization To Nucleus High-density Lipoprotein Particle Dendrite Positive Regulation Of Glycolytic Process Amyloid Precursor Protein Metabolic Process
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