CA4 and SLC4A3

Number of citations of the paper that reports this interaction (PMID 11994299)
34

Data Source:
HPRD (in vivo, in vitro)

		CA4	SLC4A3
Gene Name		carbonic anhydrase IV	solute carrier family 4 (anion exchanger), member 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Rough Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Trans-Golgi Network Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Sarcoplasmic Reticulum Transport Vesicle Membrane Secretory Granule Membrane Anchored Component Of External Side Of Plasma Membrane Brush Border Membrane Sarcolemma Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Membrane
	Molecular Function	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding	Inorganic Anion Exchanger Activity
	Biological Process	One-carbon Metabolic Process Bicarbonate Transport Response To Drug Small Molecule Metabolic Process Organ Development Response To Steroid Hormone	Transport Ion Transport Bicarbonate Transport Regulation Of Intracellular PH Transmembrane Transport Chloride Transmembrane Transport
Pathways		O2/CO2 exchange in erythrocytes Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Reversible hydration of carbon dioxide	Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport Bicarbonate transporters
Drugs		Methyclothiazide Topiramate Ethoxzolamide Bendroflumethiazide Benzthiazide Cyclothiazide Methazolamide Hydroflumethiazide Acetazolamide Dorzolamide Chlorothiazide Zonisamide Hydrochlorothiazide Trichlormethiazide Dichlorphenamide Brinzolamide Ellagic Acid
Diseases
GWAS
Protein-Protein Interactions		5 interactors: PIH1D1 PRDX2 SLC4A1 SLC4A3 SLC4A4	4 interactors: ANK1 CA2 CA4 PRKCE
Entrez ID		762	6508
HPRD ID		00261	00109
Ensembl ID		ENSG00000167434	ENSG00000114923
Uniprot IDs		P22748 Q6FHI7	P48751
PDB IDs		1ZNC 3F7B 3F7U 3FW3
Enriched GO Terms of Interacting Partners?		Bicarbonate Transport Regulation Of Intracellular PH Regulation Of Cellular PH Regulation Of PH Inorganic Anion Transport Anion Transmembrane Transport Organic Anion Transport Cellular Cation Homeostasis Cellular Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Anion Transport Chloride Transmembrane Transport Cellular Homeostasis Chloride Transport Chemical Homeostasis Box C/D SnoRNP Assembly Ion Transmembrane Transport Homeostatic Process Transmembrane Transport Ion Transport Hydrogen Peroxide Catabolic Process Removal Of Superoxide Radicals Cellular Response To Superoxide Response To Superoxide Response To Oxygen Radical Hydrogen Peroxide Metabolic Process Superoxide Metabolic Process Cellular Response To Reactive Oxygen Species	Positive Regulation Of Synaptic Transmission, GABAergic Bicarbonate Transport Regulation Of Synaptic Transmission, GABAergic One-carbon Metabolic Process Ion Transport Ion Homeostasis Positive Regulation Of Synaptic Transmission Positive Regulation Of Cellular Glucuronidation Response To Lipid Chemical Homeostasis Response To Organic Cyclic Compound Regulation Of Ion Homeostasis Positive Regulation Of Dipeptide Transmembrane Transport TRAM-dependent Toll-like Receptor 4 Signaling Pathway Regulation Of Chloride Transport Positive Regulation Of Cellular PH Reduction Homeostatic Process Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Synaptic Transmission Maintenance Of Apical/basal Cell Polarity Negative Regulation Of Sodium Ion Transmembrane Transport Angiotensin-activated Signaling Pathway Cellular Response To Ethanol Positive Regulation Of Fibroblast Migration Positive Regulation Of Organelle Organization Macrophage Activation Involved In Immune Response Locomotory Exploration Behavior Maintenance Of Cell Polarity Transport Organic Anion Transport Cellular Cation Homeostasis Negative Regulation Of Sodium Ion Transport Cellular Ion Homeostasis Metal Ion Homeostasis Response To Steroid Hormone Positive Regulation Of Bone Resorption Positive Regulation Of Mucus Secretion Cellular Response To Fluid Shear Stress Cellular Chemical Homeostasis Regulation Of Mucus Secretion Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Ion Transport Secretion Positive Regulation Of Lipid Catabolic Process Response To Organic Substance Positive Regulation Of Osteoclast Differentiation Establishment Or Maintenance Of Apical/basal Cell Polarity Exploration Behavior Anion Transport
Tagcloud ?		adrenal adrenalectomy adx alteration animals autoradiography ca1 decreased dentate hippocampus histochemistry hormones hybridization igf influenced insulin level like long mrna noted receptor receptors regions situ studied suggesting term vitro	camk1 centriole dkk1 enah endosome geo gpsm2 inference kcnq3 kpna2 lcn2 lef1 lysosome map2k6 multivesicular nkx2 nr5a1 nup62 ontology phosphoinositide sfrp4 sort1 sstr5 stx1a subnetwork tbl3 transport tshb ube2c
Tagcloud (Difference) ?		adrenal adrenalectomy adx alteration animals autoradiography ca1 decreased dentate hippocampus histochemistry hormones hybridization igf influenced insulin level like long mrna noted receptor receptors regions situ studied suggesting term vitro	camk1 centriole dkk1 enah endosome geo gpsm2 inference kcnq3 kpna2 lcn2 lef1 lysosome map2k6 multivesicular nkx2 nr5a1 nup62 ontology phosphoinositide sfrp4 sort1 sstr5 stx1a subnetwork tbl3 transport tshb ube2c
Tagcloud (Intersection) ?