CA4

Name	carbonic anhydrase 4
Structure
Novel Interactors	1 novel interactors: XPO1
Interactors	5 interactors: PIH1D1 PRDX2 SLC4A1 SLC4A3 SLC4A4
GO Annotations	Cellular Component	Rough Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Trans-Golgi Network Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Secretory Granule Membrane Brush Border Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Side Of Membrane
	Molecular Function	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Lyase Activity Metal Ion Binding
	Biological Process	Bicarbonate Transport
Pathways	Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Reversible hydration of carbon dioxide
Drugs	Methyclothiazide Topiramate Ethoxzolamide Bendroflumethiazide Benzthiazide Benzthiazide Cyclothiazide Methazolamide Hydroflumethiazide Acetazolamide Dorzolamide Zonisamide Trichlormethiazide Diclofenamide Brinzolamide Ellagic acid Sodium carbonate
Diseases	Retinitis pigmentosa (RP)
GWAS	No GWAS studies recorded
Entrez ID	762
HPRD ID	00261
Ensembl ID	ENSG00000167434
Uniprot IDs	P22748
PDB IDs	1ZNC 3F7B 3F7U 3FW3 5IPZ 5JN8 5JN9 5JNA 5JNC 5KU6
GO Terms Enriched among Interactors ?	Monoatomic Anion Transmembrane Transporter Activity Solute:inorganic Anion Antiporter Activity Bicarbonate Transport Bicarbonate Transmembrane Transporter Activity Regulation Of Cellular PH Regulation Of Intracellular PH Regulation Of PH Chloride:bicarbonate Antiporter Activity Monoatomic Anion Transmembrane Transport Inorganic Anion Transport Monoatomic Anion Transport Cellular Homeostasis Organic Anion Transport Regulation Of Glycolytic Process Regulation Of Carbohydrate Catabolic Process Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis Transport Across Blood-brain Barrier Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process PH Elevation Respiratory Burst Involved In Inflammatory Response Homeostatic Process Monoatomic Ion Homeostasis Regulation Of Biological Quality Monoatomic Cation Homeostasis Antiporter Activity Chloride Transmembrane Transport Intracellular Chemical Homeostasis Chloride Transport Inorganic Anion Transmembrane Transport Cellular Response To Triglyceride RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding TORC1 Complex Assembly Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of Glucose Mediated Signaling Pathway Inorganic Ion Transmembrane Transport Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Response To Triglyceride Sodium:bicarbonate Symporter Activity Regulation Of Glucose Mediated Signaling Pathway Monoatomic Ion Transmembrane Transport Negative Regulation Of Urine Volume Hemoglobin Binding Thioredoxin-dependent Peroxiredoxin Activity Annulate Lamellae SnoRNA Localization R2TP Complex Peroxiredoxin Activity Thioredoxin Peroxidase Activity