CA4 and SLC4A4

Number of citations of the paper that reports this interaction (PMID 14567693)
24

Data Source:
HPRD (in vitro, in vivo)

		CA4	SLC4A4
Gene Name		carbonic anhydrase IV	solute carrier family 4 (sodium bicarbonate cotransporter), member 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Rough Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Trans-Golgi Network Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Sarcoplasmic Reticulum Transport Vesicle Membrane Secretory Granule Membrane Anchored Component Of External Side Of Plasma Membrane Brush Border Membrane Sarcolemma Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding	Inorganic Anion Exchanger Activity Protein Binding Sodium:bicarbonate Symporter Activity
	Biological Process	One-carbon Metabolic Process Bicarbonate Transport Response To Drug Small Molecule Metabolic Process Organ Development Response To Steroid Hormone	Transport Ion Transport Bicarbonate Transport Sodium Ion Transmembrane Transport Regulation Of Intracellular PH Transmembrane Transport Anion Transmembrane Transport
Pathways		O2/CO2 exchange in erythrocytes Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Reversible hydration of carbon dioxide	Transport of inorganic cations/anions and amino acids/oligopeptides SLC-mediated transmembrane transport Bicarbonate transporters
Drugs		Methyclothiazide Topiramate Ethoxzolamide Bendroflumethiazide Benzthiazide Cyclothiazide Methazolamide Hydroflumethiazide Acetazolamide Dorzolamide Chlorothiazide Zonisamide Hydrochlorothiazide Trichlormethiazide Dichlorphenamide Brinzolamide Ellagic Acid
Diseases
GWAS
Protein-Protein Interactions		5 interactors: PIH1D1 PRDX2 SLC4A1 SLC4A3 SLC4A4	5 interactors: CA2 CA4 PRKACA SLC4A7 SREBF2
Entrez ID		762	8671
HPRD ID		00261	04516
Ensembl ID		ENSG00000167434	ENSG00000080493
Uniprot IDs		P22748 Q6FHI7	A5JJ20 Q9Y6R1
PDB IDs		1ZNC 3F7B 3F7U 3FW3
Enriched GO Terms of Interacting Partners?		Bicarbonate Transport Regulation Of Intracellular PH Regulation Of Cellular PH Regulation Of PH Inorganic Anion Transport Anion Transmembrane Transport Organic Anion Transport Cellular Cation Homeostasis Cellular Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Anion Transport Chloride Transmembrane Transport Cellular Homeostasis Chloride Transport Chemical Homeostasis Box C/D SnoRNP Assembly Ion Transmembrane Transport Homeostatic Process Transmembrane Transport Ion Transport Hydrogen Peroxide Catabolic Process Removal Of Superoxide Radicals Cellular Response To Superoxide Response To Superoxide Response To Oxygen Radical Hydrogen Peroxide Metabolic Process Superoxide Metabolic Process Cellular Response To Reactive Oxygen Species	Bicarbonate Transport Cellular Response To Fluid Shear Stress Response To Fluid Shear Stress One-carbon Metabolic Process Regulation Of Intracellular PH Regulation Of Cellular PH Positive Regulation Of Myeloid Leukocyte Differentiation Organic Anion Transport Cellular Cation Homeostasis Cellular Ion Homeostasis Regulation Of PH Positive Regulation Of Myeloid Cell Differentiation Cellular Chemical Homeostasis Ion Homeostasis Positive Regulation Of Dense Core Granule Biogenesis Anion Transport Regulation Of Myeloid Leukocyte Differentiation Cellular Homeostasis Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Histone H3-T6 Phosphorylation Positive Regulation Of Dipeptide Transmembrane Transport Small Molecule Metabolic Process Chemical Homeostasis Regulation Of Ion Homeostasis Response To Organic Cyclic Compound Regulation Of Myeloid Cell Differentiation Response To Organic Substance Response To Hormone Cochlear Nucleus Development Positive Regulation Of Cellular PH Reduction Retinal Cell Programmed Cell Death Regulation Of Chloride Transport Epithelium Development Negative Regulation Of Cholesterol Efflux Organ Development Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Cellular Response To Laminar Fluid Shear Stress Angiotensin-activated Signaling Pathway Regulation Of Synaptic Transmission Homeostatic Process Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Regulation Of Tight Junction Assembly Negative Regulation Of Cholesterol Transport Negative Regulation Of Glucose Import Positive Regulation Of Macrophage Differentiation Pons Development
Tagcloud ?		adrenal adrenalectomy adx alteration animals autoradiography ca1 decreased dentate hippocampus histochemistry hormones hybridization igf influenced insulin level like long mrna noted receptor receptors regions situ studied suggesting term vitro	bmp cacna1d ccl2 cd25 cd26 cdkn1a cml cure dpp4 dusp12 dysregulation eradication exploited il1rap il2ra kcnk5 lscs marcks microarrays mycn oncogenes perp persistence ptprd refined timeless tki transcriptome withdrawal
Tagcloud (Difference) ?		adrenal adrenalectomy adx alteration animals autoradiography ca1 decreased dentate hippocampus histochemistry hormones hybridization igf influenced insulin level like long mrna noted receptor receptors regions situ studied suggesting term vitro	bmp cacna1d ccl2 cd25 cd26 cdkn1a cml cure dpp4 dusp12 dysregulation eradication exploited il1rap il2ra kcnk5 lscs marcks microarrays mycn oncogenes perp persistence ptprd refined timeless tki transcriptome withdrawal
Tagcloud (Intersection) ?