CA3 and LXN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CA3	LXN
Description		carbonic anhydrase 3	latexin
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Sarcomere	Extracellular Space Cytoplasm
	Molecular Function	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Nickel Cation Binding Phosphatase Activity Lyase Activity Metal Ion Binding	Enzyme Inhibitor Activity Protein Binding Metalloendopeptidase Inhibitor Activity Heparin Binding Peptidase Inhibitor Activity
	Biological Process	Skeletal Muscle Contraction Response To Oxidative Stress Positive Regulation Of Cell Population Proliferation Response To Bacterium Cellular Response To Insulin Stimulus Response To Lipid Negative Regulation Of Apoptotic Process Cellular Response To Leptin Stimulus Response To Ethanol Cellular Response To Hypoxia Response To Alcohol Liver Regeneration Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide	Inflammatory Response Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain
Pathways		Reversible hydration of carbon dioxide
Drugs		Topiramate Ethoxzolamide Sulpiride Celecoxib Benzthiazide Valdecoxib Cyclothiazide Methazolamide Acetazolamide Dorzolamide Zonisamide Diclofenamide Brinzolamide Ellagic acid Saccharin
Diseases
GWAS		Blood protein levels ( 30072576) Blood trace element (Zn levels) ( 23720494) Estimated glomerular filtration rate ( 31152163) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin concentration ( 27863252)	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143)
Interacting Genes		3 interacting genes: HPCAL1 LXN SRC	25 interacting genes: BOC CA3 COX6A1 CYBC1 DNAJC11 DPYD FCGR3A GSG1L IGSF11 MAGEA8 MCMDC2 NSMF PAX6 PPP1R3C RNF4 SHKBP1 SPAG7 TMEM14A TRAIP TRIM39 YIF1B ZCCHC17 ZKSCAN4 ZNF430 ZNF679
Entrez ID		761	56925
HPRD ID		00260	14327
Ensembl ID		ENSG00000164879	ENSG00000079257
Uniprot IDs		P07451	Q9BS40
PDB IDs		1Z93 1Z97 2HFW 3UYN 3UYQ	2BO9
Enriched GO Terms of Interacting Partners?		Regulation Of Catalytic Activity G Protein-coupled Glutamate Receptor Signaling Pathway Scaffold Protein Binding Group II Metabotropic Glutamate Receptor Activity Astrocyte Projection Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Glutamate Receptor Activity Bone Resorption Angiotensin-activated Signaling Pathway Negative Regulation Of Hippo Signaling Negative Regulation Of Neutrophil Activation Regulation Of Toll-like Receptor 3 Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of Caveolin-mediated Endocytosis Connexin Binding Regulation Of Lamellipodium Morphogenesis Regulation Of Integrin Activation Positive Regulation Of Dephosphorylation Cellular Response To Progesterone Stimulus Positive Regulation Of Protein Maturation Intestinal Epithelial Cell Development Positive Regulation Of Podosome Assembly Regulation Of Podosome Assembly Signal Complex Assembly Positive Regulation Of Protein Processing Positive Regulation Of Integrin Activation Osteoclast Development Phospholipase Activator Activity Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Mitochondrial Depolarization Uterus Development Negative Regulation Of Focal Adhesion Assembly Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Neutrophil Activation Response To Platelet-derived Growth Factor Endolysosomal Toll-like Receptor Signaling Pathway Contractile Actin Filament Bundle Assembly Regulation Of Dephosphorylation Stress Fiber Assembly Progesterone Receptor Signaling Pathway Protein Tyrosine Kinase Activator Activity Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Phospholipase Binding Negative Regulation Of Mitochondrial Depolarization Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Columnar/cuboidal Epithelial Cell Development Negative Regulation Of Anoikis
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