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ERRFI1 and FGFR2
Number of citations of the paper that reports this interaction (PubMedID
25640309
)
0
Data Source:
BioGRID
(two hybrid)
ERRFI1
FGFR2
Description
ERBB receptor feedback inhibitor 1
fibroblast growth factor receptor 2
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Extracellular Region
Nucleus
Cytoplasm
Golgi Apparatus
Plasma Membrane
Cell Cortex
Cell Surface
Membrane
Cytoplasmic Vesicle
Receptor Complex
Excitatory Synapse
Molecular Function
GTPase Activator Activity
Protein Binding
SH3 Domain Binding
Kinase Binding
Protein Kinase Binding
Small GTPase Binding
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Fibroblast Growth Factor Receptor Activity
Protein Binding
ATP Binding
Heparin Binding
Kinase Activity
Transferase Activity
Fibroblast Growth Factor Binding
Identical Protein Binding
Protein Homodimerization Activity
Biological Process
Skeletal System Development
Liver Development
Tissue Homeostasis
Glucose Metabolic Process
Lipid Metabolic Process
Bile Acid Biosynthetic Process
Apoptotic Process
Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity
Embryo Implantation
Cholesterol Metabolic Process
Response To Xenobiotic Stimulus
Gene Expression
Cell Migration
Negative Regulation Of Protein Autophosphorylation
Response To Estradiol
Response To Progesterone
Negative Regulation Of Interleukin-1 Beta Production
Negative Regulation Of Tumor Necrosis Factor Production
Response To Insulin
Cellular Response To Insulin Stimulus
Negative Regulation Of Collagen Biosynthetic Process
Uterine Epithelium Development
Chondrocyte Proliferation
Limb Joint Morphogenesis
Cellular Response To Platelet-derived Growth Factor Stimulus
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Cholesterol Homeostasis
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Skin Development
Skin Morphogenesis
Regulation Of Keratinocyte Differentiation
Lung Alveolus Development
Response To Steroid Hormone
Epithelial Cell Proliferation
Progesterone Receptor Signaling Pathway
Cartilage Development
Uterus Development
Lung Vasculature Development
Lung Epithelium Development
Epithelium Development
Fat Pad Development
Regulation Of Type B Pancreatic Cell Proliferation
Negative Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Hyperosmotic Response
Cellular Response To Dexamethasone Stimulus
Protein Localization To Plasma Membrane
Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Response To 1-oleoyl-sn-glycerol 3-phosphate
Negative Regulation Of Transcription By RNA Polymerase II
Angiogenesis
Ureteric Bud Development
In Utero Embryonic Development
Epithelial To Mesenchymal Transition
Positive Regulation Of Mesenchymal Cell Proliferation
Outflow Tract Septum Morphogenesis
Membranous Septum Morphogenesis
Endochondral Bone Growth
Apoptotic Process
Cell-cell Signaling
Axonogenesis
Positive Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Smoothened Signaling Pathway
Post-embryonic Development
Embryonic Pattern Specification
Animal Organ Morphogenesis
Positive Regulation Of Phospholipase Activity
Negative Regulation Of Keratinocyte Proliferation
Morphogenesis Of Embryonic Epithelium
Peptidyl-tyrosine Phosphorylation
Orbitofrontal Cortex Development
Ventricular Zone Neuroblast Division
Pyramidal Neuron Development
Gland Morphogenesis
Positive Regulation Of Wnt Signaling Pathway
Bone Mineralization
Lung Development
Epithelial Cell Differentiation
Midbrain Development
Otic Vesicle Formation
Hair Follicle Morphogenesis
Response To Lipopolysaccharide
Lacrimal Gland Development
Regulation Of Osteoblast Proliferation
Organ Growth
Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow Cell
Fibroblast Growth Factor Receptor Signaling Pathway Involved In Hemopoiesis
Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow
Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development
Inner Ear Morphogenesis
Odontogenesis
Chordate Embryonic Development
Positive Regulation Of MAPK Cascade
Cellular Response To Fibroblast Growth Factor Stimulus
Cell Fate Commitment
Response To Ethanol
Regulation Of Cell Differentiation
Regulation Of Osteoblast Differentiation
Positive Regulation Of Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Protein Autophosphorylation
Lung Alveolus Development
Mesodermal Cell Differentiation
Embryonic Digestive Tract Morphogenesis
Embryonic Organ Morphogenesis
Digestive Tract Development
Embryonic Organ Development
Reproductive Structure Development
Embryonic Cranial Skeleton Morphogenesis
Skeletal System Morphogenesis
Epidermis Morphogenesis
Branching Morphogenesis Of A Nerve
Mesenchymal Cell Differentiation
Positive Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Epithelial Cell Proliferation
Regulation Of Smooth Muscle Cell Differentiation
Positive Regulation Of Cell Division
Ventricular Cardiac Muscle Tissue Morphogenesis
Positive Regulation Of Cardiac Muscle Cell Proliferation
Limb Bud Formation
Bone Development
Bone Morphogenesis
Branching Involved In Prostate Gland Morphogenesis
Branching Involved In Salivary Gland Morphogenesis
Bud Elongation Involved In Lung Branching
Lung Lobe Morphogenesis
Lung-associated Mesenchyme Development
Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Prostate Gland Morphogenesis
Prostate Epithelial Cord Elongation
Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis
Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development
Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification
Lateral Sprouting From An Epithelium
Mammary Gland Bud Formation
Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis
Branch Elongation Involved In Salivary Gland Morphogenesis
Branching Involved In Labyrinthine Layer Morphogenesis
Regulation Of Morphogenesis Of A Branching Structure
Mesenchymal Cell Differentiation Involved In Lung Development
Mesenchymal Cell Proliferation Involved In Lung Development
Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Retinoic Acid
Cellular Response To Hypoxia
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Cranial Skeletal System Development
Pathways
Signaling by FGFR2 amplification mutants
Activated point mutants of FGFR2
Signaling by FGFR2 in disease
Signaling by FGFR2 IIIa TM
Signaling by FGFR2 fusions
Drugs
Palifermin
Heparin
Sucrosofate
3-[4-(1-formylpiperazin-4-yl)-benzylidenyl]-2-indolinone
4-[4-(1-Amino-1-Methylethyl)Phenyl]-5-Chloro-N-[4-(2-Morpholin-4-Ylethyl)Phenyl]Pyrimidin-2-Amine
Regorafenib
Ponatinib
Lenvatinib
Nintedanib
Foreskin fibroblast (neonatal)
Foreskin keratinocyte (neonatal)
Infigratinib
Fostamatinib
Erdafitinib
Pemigatinib
Futibatinib
Selpercatinib
Pralsetinib
Diseases
Lacrimo-auriculo-dento-digital syndrome (LADD); Levy-Hollister syndrome
Gastric cancer
Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS
Crohn's disease (
28067908
)
Hair shape (
29220522
)
HDL cholesterol levels in HIV infection (
33109212
)
Inflammatory bowel disease (
28067908
)
Ischemic stroke (
24262325
)
Morning person (
30696823
)
Response to antidepressants and depression (
27622933
)
Strep throat (
28928442
)
Ulcerative colitis (
28067908
)
Waist circumference adjusted for body mass index (
34021172
)
Adiponectin levels (
24105470
)
Attention deficit hyperactivity disorder (hyperactivity-impulsivity symptoms) (
32595297
)
Benign prostatic hyperplasia and lower urinary tract symptoms (
30410027
)
Body mass index (
28892062
)
BRCA1/2-negative high-risk breast cancer (
30323354
)
Breast cancer (
17529973
31757997
29059683
25956309
24143190
23354978
22951594
21263130
19330030
20453838
20872241
23535729
17529967
)
Breast cancer (early onset) (
24493630
)
Breast cancer (estrogen-receptor positive) (
28864454
)
Breast cancer (progesterone-receptor positive) (
28864454
)
Breast cancer in BRCA2 mutation carriers (
23544012
21060860
)
Cancer (pleiotropy) (
27197191
)
Childhood ear infection (
27182965
)
Core binding factor acute myeloid leukemia (
27903959
)
Coronary artery disease (
32469254
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Estrogen receptor status in breast cancer (
27764800
)
Estrogen receptor status in HER2 negative breast cancer (
27764800
)
High density lipoprotein cholesterol levels (
29403010
33339817
)
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Magnesium levels (
26685716
)
PR interval (
32439900
)
Prostate cancer (
31562322
)
Prostate-specific antigen levels (
30410027
28139693
)
Prostate-specific antigen levels (conditioned on lead SNPs) (
28139693
)
Serum prostate-specific antigen levels (
21160077
)
Systolic blood pressure (
30224653
)
Triglyceride levels (
32203549
)
Type 2 diabetes (
30718926
32499647
)
Vaginal microbiome composition (L. iners) (
32723796
)
Waist-to-hip ratio adjusted for BMI (additive genetic model) (
30778226
)
Interacting Genes
58 interacting genes:
ACBD3
ADAM5
AGPAT4-IT1
AOX1
ARRDC5
ATM
AURKA
BAG4
BCAR3
CASP8
CDC42
CIAO2B
COPS5
CRHBP
DCTN6
EFEMP1
EGFR
ERBB2
FGFR2
FGFR4
GAS1
GNPDA2
GTF2H2
HYDIN
IL2RG
MMP26
NEDD4
NEU1
NPC2
OSTF1
PALB2
PAPSS1
PCCA
PCNA
PDCD2
PHYHIPL
PLEKHA3
PPIA
PPM1D
PSMA7
PSMB6
RAB18
RB1CC1
RUBCNL
SH3YL1
SKIC8
SLC61A1
SLC7A13
SMIM30
SRC
TC2N
TIMP4
TM2D3
TMEM165
TMEM59
WEE1
YWHAB
ZPBP
45 interacting genes:
ANOS1
APP
BEX1
BEX2
CACNA1D
CTDSP1
CTDSPL
DUSP14
EPHA4
ERBB2
ERRFI1
FBXO7
FGF1
FGF10
FGF17
FGF18
FGF23
FGF3
FGF4
FGF5
FGF6
FGF7
FGF8
FGF9
GLCE
HOXC6
ITGA5
LRRK1
MTA3
MTMR3
NECTIN1
NEDD4
PAK4
PDLIM2
PLCG1
PPM1A
PTK2B
PTPN11
PTPN12
PTPRR
RASL10B
RHOBTB2
S100A14
SHC1
TFF1
Entrez ID
54206
2263
HPRD ID
09218
01492
Ensembl ID
ENSG00000116285
ENSG00000066468
Uniprot IDs
B3KTV8
I6S2Y9
Q9UJM3
A0A141AXF1
D2CGD1
P21802
S4R381
PDB IDs
2RF9
2RFD
2RFE
4I21
4R3P
4R3R
4ZJV
1DJS
1E0O
1EV2
1GJO
1II4
1IIL
1NUN
1OEC
1WVZ
2FDB
2PSQ
2PVF
2PVY
2PWL
2PY3
2PZ5
2PZP
2PZR
2Q0B
3B2T
3CAF
3CLY
3CU1
3DAR
3EUU
3OJ2
3OJM
3RI1
4J23
4J95
4J96
4J97
4J98
4J99
4WV1
5EG3
5UGL
5UGX
5UHN
5UI0
6AGX
6LVK
6LVL
6V6Q
7KIA
7KIE
7OZY
8E1X
8H75
8STG
8SWE
8U1F
8W2X
8W38
8W3B
8W3D
Enriched GO Terms of Interacting Partners
?
Peptidyl-tyrosine Phosphorylation
Epidermal Growth Factor Receptor Signaling Pathway
Protein Tyrosine Kinase Activity
Enzyme Binding
ERBB Signaling Pathway
Positive Regulation Of MAPK Cascade
Transmembrane Receptor Protein Tyrosine Kinase Activity
Epidermal Growth Factor Receptor Activity
Protein Autophosphorylation
Regulation Of MAPK Cascade
ERBB2 Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Catalytic Activity
Fibroblast Growth Factor Receptor Activity
Protein Phosphorylation
Phosphoserine Residue Binding
Kinase Activity
Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Phosphorylation
Protein Kinase Activity
ERBB2-EGFR Signaling Pathway
Cellular Response To Growth Factor Stimulus
Ruffle Membrane
Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis
Positive Regulation Of DNA Replication
Positive Regulation Of DNA Biosynthetic Process
Animal Organ Development
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Response To Estradiol
Endothelin Receptor Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cellular Response To Epidermal Growth Factor Stimulus
Receptor Complex
Response To Epidermal Growth Factor
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Response To Growth Factor
Progesterone Receptor Signaling Pathway
G2/M Transition Of Mitotic Cell Cycle
Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Cis-Golgi Network Membrane
Cell Cycle G2/M Phase Transition
DNA Repair Complex
Fibroblast Growth Factor Receptor Signaling Pathway
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Regulation Of MAPK Cascade
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of MAPK Cascade
Growth Factor Activity
Neurogenesis
Fibroblast Growth Factor Receptor Binding
Regulation Of ERK1 And ERK2 Cascade
Regulation Of Locomotion
Type 2 Fibroblast Growth Factor Receptor Binding
Regulation Of Cell Migration
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Cell Motility
Positive Regulation Of Cell Population Proliferation
Regulation Of Intracellular Signal Transduction
Regulation Of Cell Population Proliferation
Regulation Of Signal Transduction
Positive Regulation Of Signal Transduction
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Cell Surface Receptor Signaling Pathway
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Cell Division
Type 1 Fibroblast Growth Factor Receptor Binding
Signal Transduction
ERBB Signaling Pathway
Protein Dephosphorylation
Phosphoprotein Phosphatase Activity
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Developmental Process
Developmental Process
Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Cell Division
Positive Regulation Of Cell Migration
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cell Motility
Dephosphorylation
Cellular Response To Growth Factor Stimulus
Positive Regulation Of Locomotion
Regulation Of Anatomical Structure Morphogenesis
Cellular Response To Epidermal Growth Factor Stimulus
Regulation Of Multicellular Organismal Process
Response To Growth Factor
Protein Tyrosine Phosphatase Activity
Heparin Binding
Response To Epidermal Growth Factor
Lung Development
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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