XRCC2 and RAD51D

Number of citations of the paper that reports this interaction (PubMedID 34591612)
132

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, two hybrid, in vitro)

		XRCC2	RAD51D
Description		X-ray repair cross complementing 2	RAD51 paralog D
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Cytoplasm Centrosome Cytoskeleton Rad51B-Rad51C-Rad51D-XRCC2 Complex	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Cytoplasm Centrosome Microtubule Organizing Center Cytoskeleton Rad51B-Rad51C-Rad51D-XRCC2 Complex
	Molecular Function	Four-way Junction DNA Binding DNA Binding Protein Binding ATP Binding ATP-dependent DNA Damage Sensor Activity	Nucleotide Binding Four-way Junction DNA Binding DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Gamma-tubulin Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process	Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Somitogenesis DNA Repair DNA Recombination DNA Damage Response Centrosome Cycle Response To X-ray Response To Gamma Radiation Neurogenesis Multicellular Organism Growth DNA Strand Invasion Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neurogenesis Meiotic Cell Cycle Regulation Of Fibroblast Apoptotic Process	Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination DNA Damage Response Reciprocal Meiotic Recombination Interstrand Cross-link Repair DNA Strand Invasion Chromosome Organization Regulation Of Cell Cycle
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange TP53 Regulates Transcription of DNA Repair Genes Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2
Drugs
Diseases
GWAS		Diabetic kidney disease ( 26305897) Mean platelet volume ( 27863252 32888494) Palmitic acid (16:0) levels ( 23362303)
Interacting Genes		5 interacting genes: MEOX2 NKIRAS1 RAD51 RAD51D WFDC1	49 interacting genes: AMOTL2 BLM C1orf94 CCDC33 CCNL1 CEP57L1 EFHC2 GEMIN4 HSF2BP IHO1 IKZF1 IKZF3 KATNBL1 KIFC3 KRT15 LIMS1 LNX1 LZTS2 MAPK8IP3 MEOX2 NFKBID PICK1 PNMA1 POLDIP3 PRDM14 PRDM6 RAD51B RAD51C RBM48 REL RHOU RNF138 SORBS3 SPATC1L STX11 SWSAP1 TCF4 TEPSIN TLE5 TRIM14 TTC23 VPS9D1 XRCC2 XRCC3 ZBTB42 ZC2HC1C ZNF343 ZNF774 ZSWIM7
Entrez ID		7516	5892
HPRD ID		02656	04261
Ensembl ID		ENSG00000196584	ENSG00000185379
Uniprot IDs		A0A384MEK2 O43543	O75771
PDB IDs		8FAZ 8GBJ 8OUY 8OUZ	2KZ3 8FAZ 8GBJ 8OUY 8OUZ
Enriched GO Terms of Interacting Partners?		DNA Strand Invasion ATP-dependent DNA Damage Sensor Activity Telomere Maintenance Via Recombination Mitotic Recombination Reciprocal Meiotic Recombination ATP-dependent Activity, Acting On DNA Homologous Recombination Interstrand Cross-link Repair Response To Glucoside Telomere Maintenance Mitotic Recombination-dependent Replication Fork Processing Single-stranded DNA Binding Double-strand Break Repair Via Homologous Recombination DNA Strand Exchange Activity Telomere Organization Presynaptic Intermediate Filament Cytoskeleton Recombinational Repair Cellular Response To Cisplatin Chromosome, Telomeric Region Rad51B-Rad51C-Rad51D-XRCC2 Complex Ral Protein Signal Transduction Somite Specification DNA Recombinase Assembly Cellular Response To Camptothecin Nuclear Ubiquitin Ligase Complex Double-strand Break Repair Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Response To Cisplatin DNA Recombination Response To Glycoside Double-strand Break Repair Involved In Meiotic Recombination Cellular Response To Hydroxyurea GTPase Activating Protein Binding Response To Hydroxyurea Chromosome Organization Lateral Element Segment Specification Somite Development Four-way Junction DNA Binding Single-stranded DNA Helicase Activity Surfactant Homeostasis DNA Polymerase Binding Regulation Of DNA Damage Checkpoint Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Nucleotide Binding Telomere Maintenance Via Telomere Lengthening Nuclear Chromosome Response To X-ray DNA Repair Cellular Response To Gamma Radiation	Four-way Junction DNA Binding Recombinational Repair Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Replication Fork DNA Recombination Rad51B-Rad51C-Rad51D-XRCC2 Complex ATP-dependent DNA Damage Sensor Activity Protein Binding Rad51C-XRCC3 Complex Shu Complex DNA Repair DNA Metabolic Process DNA Binding Resolution Of DNA Recombination Intermediates Single-stranded DNA Binding Crossover Junction DNA Endonuclease Activity DNA Damage Response Telomeric Loop Disassembly T-circle Formation Telomere Maintenance Via Recombination Zinc Ion Binding Somite Development Meiosis I Cell Cycle Process
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