XRCC2 and WFDC1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		XRCC2	WFDC1
Name		X-ray repair cross complementing 2	WAP four-disulfide core domain 1
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Cytoplasm Centrosome Cytoskeleton Rad51B-Rad51C-Rad51D-XRCC2 Complex	Extracellular Region Extracellular Space
	Molecular Function	Four-way Junction DNA Binding DNA Binding Protein Binding ATP Binding ATP-dependent DNA Damage Sensor Activity	Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity
	Biological Process	Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination In Utero Embryonic Development Somitogenesis DNA Repair DNA Recombination DNA Damage Response Centrosome Cycle Response To X-ray Response To Gamma Radiation Neurogenesis Multicellular Organism Growth DNA Strand Invasion Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neurogenesis Meiotic Cell Cycle Regulation Of Fibroblast Apoptotic Process	Regulation Of Cell Growth Negative Regulation Of Cell Growth Negative Regulation Of Inflammatory Response Negative Regulation Of Wound Healing
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to PALB2	None
GWAS		Diabetic kidney disease ( 26305897 ) Mean platelet volume ( 27863252 32888494 ) Palmitic acid (16:0) levels ( 23362303 )	Blood protein levels ( 30072576 ) Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment ( 32472697 ) Systolic blood pressure (alcohol consumption interaction) ( 24376456 ) Systolic blood pressure (baseline) ( 33603002 ) Visceral adipose tissue adjusted for BMI ( 22589738 )
Novel Interactors		None recorded	1 novel interactors: ETF1
Interacting Genes		5 interacting genes: MEOX2 NKIRAS1 RAD51 RAD51D WFDC1	5 interacting genes: EZR FOSL1 RAB40B XRCC2 ZNF677
Entrez ID		7516	58189
HPRD ID		02656	05614
Ensembl ID		ENSG00000196584	ENSG00000103175
Uniprot IDs		A0A384MEK2 O43543	Q9HC57
PDB IDs		8FAZ 8GBJ 8OUY 8OUZ	Not available
GO Terms Enriched among Interactors		DNA Strand Invasion ATP-dependent DNA Damage Sensor Activity Telomere Maintenance Via Recombination Mitotic Recombination Reciprocal Meiotic Recombination ATP-dependent Activity, Acting On DNA Homologous Recombination Interstrand Cross-link Repair Response To Glucoside Telomere Maintenance Mitotic Recombination-dependent Replication Fork Processing Single-stranded DNA Binding Double-strand Break Repair Via Homologous Recombination DNA Strand Exchange Activity Telomere Organization Presynaptic Intermediate Filament Cytoskeleton Recombinational Repair Cellular Response To Cisplatin Chromosome, Telomeric Region Rad51B-Rad51C-Rad51D-XRCC2 Complex Ral Protein Signal Transduction Somite Specification DNA Recombinase Assembly Cellular Response To Camptothecin Nuclear Ubiquitin Ligase Complex Double-strand Break Repair Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Response To Cisplatin DNA Recombination Response To Glycoside Double-strand Break Repair Involved In Meiotic Recombination Cellular Response To Hydroxyurea GTPase Activating Protein Binding Response To Hydroxyurea Chromosome Organization Lateral Element Segment Specification Somite Development Four-way Junction DNA Binding Single-stranded DNA Helicase Activity Surfactant Homeostasis DNA Polymerase Binding Regulation Of DNA Damage Checkpoint Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Nucleotide Binding Telomere Maintenance Via Telomere Lengthening Nuclear Chromosome Response To X-ray DNA Repair Cellular Response To Gamma Radiation	None