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XRCC2
Description
X-ray repair cross complementing 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Replication Fork
Cytoplasm
Centrosome
Cytoskeleton
Rad51B-Rad51C-Rad51D-XRCC2 Complex
Molecular Function
Four-way Junction DNA Binding
DNA Binding
Protein Binding
ATP Binding
ATP-dependent DNA Damage Sensor Activity
Biological Process
Mitotic Cell Cycle
Double-strand Break Repair Via Homologous Recombination
In Utero Embryonic Development
Somitogenesis
DNA Repair
DNA Recombination
DNA Damage Response
Centrosome Cycle
Response To X-ray
Response To Gamma Radiation
Neurogenesis
Multicellular Organism Growth
DNA Strand Invasion
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Neurogenesis
Meiotic Cell Cycle
Regulation Of Fibroblast Apoptotic Process
Pathways
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Presynaptic phase of homologous DNA pairing and strand exchange
Defective homologous recombination repair (HRR) due to BRCA1 loss of function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Impaired BRCA2 binding to PALB2
Drugs
Diseases
GWAS
Diabetic kidney disease (
26305897
)
Mean platelet volume (
27863252
32888494
)
Palmitic acid (16:0) levels (
23362303
)
Interacting Genes
5 interacting genes:
MEOX2
NKIRAS1
RAD51
RAD51D
WFDC1
Entrez ID
7516
HPRD ID
02656
Ensembl ID
ENSG00000196584
Uniprot IDs
A0A384MEK2
O43543
PDB IDs
8FAZ
8GBJ
8OUY
8OUZ
Enriched GO Terms of Interacting Partners
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DNA Strand Invasion
ATP-dependent DNA Damage Sensor Activity
Telomere Maintenance Via Recombination
Mitotic Recombination
Reciprocal Meiotic Recombination
ATP-dependent Activity, Acting On DNA
Homologous Recombination
Interstrand Cross-link Repair
Response To Glucoside
Telomere Maintenance
Mitotic Recombination-dependent Replication Fork Processing
Single-stranded DNA Binding
Double-strand Break Repair Via Homologous Recombination
DNA Strand Exchange Activity
Telomere Organization
Presynaptic Intermediate Filament Cytoskeleton
Recombinational Repair
Cellular Response To Cisplatin
Chromosome, Telomeric Region
Rad51B-Rad51C-Rad51D-XRCC2 Complex
Ral Protein Signal Transduction
Somite Specification
DNA Recombinase Assembly
Cellular Response To Camptothecin
Nuclear Ubiquitin Ligase Complex
Double-strand Break Repair
Replication-born Double-strand Break Repair Via Sister Chromatid Exchange
Response To Cisplatin
DNA Recombination
Response To Glycoside
Double-strand Break Repair Involved In Meiotic Recombination
Cellular Response To Hydroxyurea
GTPase Activating Protein Binding
Response To Hydroxyurea
Chromosome Organization
Lateral Element
Segment Specification
Somite Development
Four-way Junction DNA Binding
Single-stranded DNA Helicase Activity
Surfactant Homeostasis
DNA Polymerase Binding
Regulation Of DNA Damage Checkpoint
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Nucleotide Binding
Telomere Maintenance Via Telomere Lengthening
Nuclear Chromosome
Response To X-ray
DNA Repair
Cellular Response To Gamma Radiation
Tagcloud
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