TRPV1 and ITCH

Number of citations of the paper that reports this interaction (PMID 17110928)
14

Data Source:
HPRD (in vivo)

		TRPV1	ITCH
Gene Name		transient receptor potential cation channel, subfamily V, member 1	itchy E3 ubiquitin protein ligase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Cell Junction Intrinsic Component Of Plasma Membrane Dendritic Spine Membrane Postsynaptic Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Cell Cortex Membrane Cytoplasmic Vesicle Extracellular Vesicular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity Excitatory Extracellular Ligand-gated Ion Channel Activity Calcium Channel Activity Calmodulin Binding ATP Binding Calcium-release Channel Activity Phosphoprotein Binding	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Ribonucleoprotein Complex Binding CXCR Chemokine Receptor Binding Ubiquitin Protein Ligase Activity
	Biological Process	Transport Cell Surface Receptor Signaling Pathway Chemosensory Behavior Ion Transmembrane Transport Thermoception Transmembrane Transport Calcium Ion Transmembrane Transport Cellular Response To Alkaloid Cellular Response To ATP	Regulation Of Cell Growth Positive Regulation Of T Cell Anergy Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Inflammatory Response Notch Signaling Pathway Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Type I Interferon Production Protein K29-linked Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Protein Catabolic Process Negative Regulation Of JNK Cascade Negative Regulation Of Alpha-beta T Cell Proliferation Viral Entry Into Host Cell Negative Regulation Of Defense Response To Virus Defense Response To Virus Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Regulation Of Protein Deubiquitination
Pathways		Ion channel transport TRP channels Stimuli-sensing channels	Signaling by NOTCH1 HD Domain Mutants in Cancer Hedgehog 'off' state Antigen processing: Ubiquitination & Proteasome degradation Negative regulators of RIG-I/MDA5 signaling Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOD1/2 Signaling Pathway Signaling by NOTCH1 Hedgehog 'on' state Signaling by NOTCH1 in Cancer Class I MHC mediated antigen processing & presentation FBXW7 Mutants and NOTCH1 in Cancer Innate Immune System Downregulation of ERBB4 signaling Signaling by NOTCH Signaling by ERBB4 Activated NOTCH1 Transmits Signal to the Nucleus RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by Hedgehog Degradation of GLI1 by the proteasome Adaptive Immune System
Drugs		Alpha-Linolenic Acid Icosapent Aspartame
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CALM1 EGFR ITCH PRKCE SNAPIN SYT9 TRPV2	80 interactors: ARID1A ARRB2 ARRDC1 ARRDC3 ATN1 BECN1 CBL CBLC CDC34 CPSF6 CPSF7 CSNK2A1 CXCR4 CYLD DAZAP1 DTX1 DTX3L DVL2 ERBB4 EWSR1 FYN GNAI2 HNRNPL HNRNPUL1 JUN LAPTM5 LATS1 LITAF MAP2K4 MAPK8 MLANA N4BP1 NDFIP2 NEDD9 NFE2 NOTCH1 NUDT21 NUMB PABPC1 POLR2A POLR2B POLR2C POLR2E POU5F1 PRKACA RIPK1 RNF11 RPAP2 RPAP3 SCNN1A SCNN1B SF1 SGK3 SH3GL2 SMAD2 SMAD3 SMARCC1 SMARCC2 SMARCE1 SNX9 SPG20 STAM2 TP73 TRPC4 TRPV1 TRPV4 TXNIP UBAP2 UBAP2L UBC UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2G1 UBE2J2 UBE2K UBE2L3 URI1 WBP2
Entrez ID		7442	83737
HPRD ID		03648	07565
Ensembl ID		ENSG00000196689	ENSG00000078747
Uniprot IDs		E7EQ78 Q8NER1	Q96J02
PDB IDs			2DMV 2KYK 2NQ3 2P4R 2YSF 3TUG
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transport Activation Of Phospholipase C Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Cellular Localization Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Innate Immune Response Regulation Of Nitric-oxide Synthase Activity Fc Receptor Signaling Pathway Regulation Of Immune Response Negative Regulation Of Transporter Activity Negative Regulation Of Ion Transmembrane Transport Negative Regulation Of Transmembrane Transport Regulation Of Cytokinesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Abiotic Stimulus Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Ion Transmembrane Transport Regulation Of Intracellular Transport Regulation Of Oxidoreductase Activity Positive Regulation Of Ion Transmembrane Transport Immune Response Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Cellular Ketone Metabolic Process Alkanesulfonate Metabolic Process Positive Regulation Of Late Endosome To Lysosome Transport Positive Regulation Of Cellular Glucuronidation Defense Response Positive Regulation Of Calcium Ion Transport Calcium-mediated Signaling Negative Regulation Of Ion Transport Positive Regulation Of Synaptic Transmission Regulation Of Phosphorus Metabolic Process Reactive Oxygen Species Metabolic Process Cellular Response To Growth Factor Stimulus Response To Calcium Ion Response To Growth Factor Regulation Of MAPK Cascade TRAM-dependent Toll-like Receptor 4 Signaling Pathway Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling	Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Response To Stimulus RNA Metabolic Process Gene Expression Transcription From RNA Polymerase II Promoter Response To Growth Factor Positive Regulation Of Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Cellular Response To Stimulus Cellular Response To Growth Factor Stimulus Regulation Of RNA Metabolic Process Positive Regulation Of Signal Transduction Protein Ubiquitination Response To Organic Substance Cellular Response To Organic Substance Protein K48-linked Ubiquitination Positive Regulation Of Cellular Biosynthetic Process Protein Modification By Small Protein Conjugation Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Protein Polyubiquitination Regulation Of Signaling Macromolecule Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Modification Process Nucleobase-containing Compound Metabolic Process Nucleosome Disassembly TRIF-dependent Toll-like Receptor Signaling Pathway Programmed Cell Death MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Cellular Protein Catabolic Process Regulation Of Cellular Component Organization DNA-templated Transcription, Initiation Cell Death Death MRNA Splicing, Via Spliceosome
Tagcloud ?		6h ag anandamide arachidonoylglycerol ascaris beagle cannabinoid capsaicin cb1 cb2 congener dependently desensitization desensitized dogs endocannabinoid hek hypersensitive ic50 keratinocytes micronized mum palmitoylethanolamide pea spontaneously suum ultramicronized vanilloid volunteers	ascertain benzoin biweekly break clearance clinic convenience eradicating erosions ethanol individual irritation ns paint pb pe penile penis podophyllin regimens resin sequentially superficial supervised tincture treated wart warts week
Tagcloud (Difference) ?		6h ag anandamide arachidonoylglycerol ascaris beagle cannabinoid capsaicin cb1 cb2 congener dependently desensitization desensitized dogs endocannabinoid hek hypersensitive ic50 keratinocytes micronized mum palmitoylethanolamide pea spontaneously suum ultramicronized vanilloid volunteers	ascertain benzoin biweekly break clearance clinic convenience eradicating erosions ethanol individual irritation ns paint pb pe penile penis podophyllin regimens resin sequentially superficial supervised tincture treated wart warts week
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