MED14

Description		mediator complex subunit 14
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane Mediator Complex Core Mediator Complex
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Nuclear Vitamin D Receptor Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription Elongation By RNA Polymerase II Somatic Stem Cell Population Maintenance Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Initiation By RNA Polymerase II
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation RSV-host interactions MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS		Migraine ( 27322543)
Interacting Genes		20 interacting genes: ACTN1 ACTN2 AR CEBPA DCTN1 ESR1 ESR2 FBXL17 HNF4A MED1 MED29 MED9 NECAB2 NR3C1 PARP1 PPARGC1A SREBF1 STAT2 UACA VDR
Entrez ID		9282
HPRD ID		02172
Ensembl ID		ENSG00000180182
Uniprot IDs		O60244
PDB IDs		7EMF 7ENA 7ENC 7ENJ 7LBM 7NVR 8GXQ 8GXS 8T9D 8TQW 8TRH
Enriched GO Terms of Interacting Partners?		Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nuclear Receptor Activity Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Intracellular Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of Biosynthetic Process Estrogen Response Element Binding Sequence-specific DNA Binding Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Mammary Gland Branching Involved In Pregnancy Nuclear Steroid Receptor Activity Hormone-mediated Signaling Pathway Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process DNA-templated Transcription DNA-binding Transcription Factor Activity Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Steroid Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Response To Lipid Nucleoplasm Response To Steroid Hormone Regulation Of Macromolecule Biosynthetic Process Nucleobase-containing Compound Biosynthetic Process Regulation Of Primary Metabolic Process Response To Hormone RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway DNA Binding Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Chromatin Binding Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
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