RXRB and SPOPL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RXRB	SPOPL
Description		retinoid X receptor beta	speckle type BTB/POZ protein like
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex	Nucleus Cytoplasm Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Chromatin DNA Binding Sequence-specific DNA Binding Retinoic Acid-responsive Element Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding
	Biological Process	In Utero Embryonic Development Maternal Placenta Development Regulation Of DNA-templated Transcription Nervous System Development Hormone-mediated Signaling Pathway Cell Differentiation Positive Regulation Of Bone Mineralization Nuclear Receptor-mediated Steroid Hormone Signaling Pathway MRNA Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Ventricular Cardiac Muscle Cell Differentiation Cardiac Muscle Cell Proliferation Positive Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Retinoic Acid	Protein Ubiquitination Regulation Of Proteolysis Negative Regulation Of Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		PPARA activates gene expression Nuclear Receptor transcription pathway Signaling by Retinoic Acid NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	Hedgehog 'on' state
Drugs		Adapalene Bexarotene Rosiglitazone Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Bezafibrate LG-100268 Phthalic Acid Doconexent TO-901317 N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID
Diseases
GWAS		Wegener's granulomatosis ( 23740775)	Response to antipsychotic treatment ( 23241943)
Interacting Genes		47 interacting genes: AKAP13 CACNA1B CALCOCO2 CCDC57 EXOSC8 GOLGA2 GTF2H1 KRT40 MAP4 MID2 MYG1 NCOA1 NCOA3 NR0B2 NR1H2 NR1H3 NR1I2 NR2C2 NR2E3 NR3C1 NR4A2 NRIP1 PICK1 PLSCR1 PPARD PPARG PSTPIP1 PTMS RARA RARB RARG SIAH1 SPOP SPOPL TACC2 TADA3 TAF11 TFCP2 TFIP11 THRA THRB TP53BP2 TRIM27 TRIM37 UBL7 VDR ZDHHC12	6 interacting genes: ATF2 CREB5 EPS15 KPNA5 MYD88 RXRB
Entrez ID		6257	339745
HPRD ID		01578	11261
Ensembl ID		ENSG00000204231	ENSG00000144228
Uniprot IDs		A0A0G2JKR7 A0A0S2Z570 B7Z7J5 P28702 Q5STP9	Q6IQ16
PDB IDs		1H9U 1UHL 5HJP 5I4V 5KYA 5KYJ 7A78
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Hormone-mediated Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Nuclear Retinoid X Receptor Binding Retinoic Acid Receptor Signaling Pathway MRNA Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process MRNA Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process DNA-binding Transcription Factor Activity Transcription By RNA Polymerase II Chromatin Nuclear Receptor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm DNA-templated Transcription Zinc Ion Binding Regulation Of RNA Metabolic Process MRNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cholesterol Storage Intracellular Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Regulation Of Metabolic Process Nucleus	CAMP Response Element Binding Abducens Nucleus Development MRNA Transcription MRNA Transcription By RNA Polymerase II Hypoglossal Nucleus Development JNK Cascade Establishment Of Protein Localization To Organelle TIR Domain Binding Toll Binding ATP-dependent Histone Chaperone Activity Induced Systemic Resistance Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Anisomycin Growth Plate Cartilage Chondrocyte Differentiation Protein Localization To Organelle Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Positive Regulation Of Cardiac Muscle Myoblast Proliferation Facial Nucleus Development Histone H2B Acetyltransferase Activity Import Into Nucleus Sequence-specific Double-stranded DNA Binding H4 Histone Acetyltransferase Complex Positive Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of DNA-binding Transcription Factor Activity Growth Plate Cartilage Chondrocyte Proliferation DNA-binding Transcription Factor Activity Protein Import Into Nucleus RNA Polymerase II Transcription Regulator Complex Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 8 Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Anisomycin NK T Cell Differentiation Detection Of Cell Density Identical Protein Binding Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of DNA-binding Transcription Factor Activity Protein Localization To Nucleus Positive Regulation Of RNA Metabolic Process Response To Molecule Of Fungal Origin Ubiquitin-dependent Endocytosis Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Toll-like Receptor Binding Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Vitamin D Receptor Signaling Pathway Brainstem Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis
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