RXRB and ZDHHC12

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RXRB	ZDHHC12
Description		retinoid X receptor beta	zDHHC palmitoyltransferase 12
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Dendritic Spine
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Chromatin DNA Binding Sequence-specific DNA Binding Retinoic Acid-responsive Element Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Palmitoyltransferase Activity Transferase Activity Acyltransferase Activity Protein-cysteine S-palmitoyltransferase Activity
	Biological Process	In Utero Embryonic Development Maternal Placenta Development Regulation Of DNA-templated Transcription Nervous System Development Hormone-mediated Signaling Pathway Cell Differentiation Positive Regulation Of Bone Mineralization Nuclear Receptor-mediated Steroid Hormone Signaling Pathway MRNA Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Ventricular Cardiac Muscle Cell Differentiation Cardiac Muscle Cell Proliferation Positive Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Retinoic Acid	Protein Targeting To Membrane Peptidyl-L-cysteine S-palmitoylation Protein Catabolic Process Positive Regulation Of Synaptic Transmission, GABAergic Synaptic Transmission, GABAergic Chaperone-mediated Autophagy Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Gamma-aminobutyric Acid Receptor Clustering Gephyrin Clustering Involved In Postsynaptic Density Assembly Negative Regulation Of NLRP3 Inflammasome Complex Assembly
Pathways		PPARA activates gene expression Nuclear Receptor transcription pathway Signaling by Retinoic Acid NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Drugs		Adapalene Bexarotene Rosiglitazone Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Bezafibrate LG-100268 Phthalic Acid Doconexent TO-901317 N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID
Diseases
GWAS		Wegener's granulomatosis ( 23740775)	Asthma ( 31361310 32296059) Axial length ( 24144296) Body mass index ( 26426971) Eating disorders (purging via substances) ( 23568457)
Interacting Genes		47 interacting genes: AKAP13 CACNA1B CALCOCO2 CCDC57 EXOSC8 GOLGA2 GTF2H1 KRT40 MAP4 MID2 MYG1 NCOA1 NCOA3 NR0B2 NR1H2 NR1H3 NR1I2 NR2C2 NR2E3 NR3C1 NR4A2 NRIP1 PICK1 PLSCR1 PPARD PPARG PSTPIP1 PTMS RARA RARB RARG SIAH1 SPOP SPOPL TACC2 TADA3 TAF11 TFCP2 TFIP11 THRA THRB TP53BP2 TRIM27 TRIM37 UBL7 VDR ZDHHC12	1 interacting genes: RXRB
Entrez ID		6257	84885
HPRD ID		01578	15709
Ensembl ID		ENSG00000204231	ENSG00000160446
Uniprot IDs		A0A0G2JKR7 A0A0S2Z570 B7Z7J5 P28702 Q5STP9	Q96GR4
PDB IDs		1H9U 1UHL 5HJP 5I4V 5KYA 5KYJ 7A78
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Hormone-mediated Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Nuclear Retinoid X Receptor Binding Retinoic Acid Receptor Signaling Pathway MRNA Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process MRNA Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Sequence-specific DNA Binding Positive Regulation Of Biosynthetic Process DNA-binding Transcription Factor Activity Transcription By RNA Polymerase II Chromatin Nuclear Receptor Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleoplasm DNA-templated Transcription Zinc Ion Binding Regulation Of RNA Metabolic Process MRNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cholesterol Storage Intracellular Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Regulation Of Metabolic Process Nucleus	Ventricular Cardiac Muscle Cell Differentiation Maternal Placenta Development Positive Regulation Of Vitamin D Receptor Signaling Pathway Regulation Of Vitamin D Receptor Signaling Pathway Retinoic Acid-responsive Element Binding Muscle Cell Proliferation MRNA Transcription By RNA Polymerase II Cardiac Muscle Cell Proliferation Cardiac Muscle Cell Differentiation Regulation Of Response To Nutrient Levels Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Ossification Cardiocyte Differentiation Nuclear Receptor Activity Positive Regulation Of Bone Mineralization Maternal Process Involved In Female Pregnancy Positive Regulation Of Biomineral Tissue Development Nuclear Steroid Receptor Activity MRNA Transcription Regulation Of Bone Mineralization Striated Muscle Cell Differentiation Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Cellular Response To Retinoic Acid Chromatin DNA Binding Response To Retinoic Acid Nuclear Receptor-mediated Signaling Pathway Muscle Cell Differentiation Regulation Of Ossification RNA Polymerase II Transcription Regulator Complex Hormone-mediated Signaling Pathway
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