PRCP

Description		prolylcarboxypeptidase
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GO Annotations	Cellular Component	Extracellular Region Lysosome Plasma Membrane Azurophil Granule Membrane Basal Part Of Cell Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Carboxypeptidase Activity Metallocarboxypeptidase Activity Serine-type Carboxypeptidase Activity Protein Binding Peptidase Activity Dipeptidyl-peptidase Activity Hydrolase Activity Serine-type Exopeptidase Activity
	Biological Process	Angiotensin Maturation Regulation Of Thyroid Hormone Receptor Signaling Pathway Plasma Kallikrein-kinin Cascade Negative Regulation Of Systemic Arterial Blood Pressure Proteolysis Glucose Homeostasis Regulation Of Blood Vessel Endothelial Cell Migration Angiogenesis Involved In Wound Healing Energy Homeostasis Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Intrinsic Pathway of Fibrin Clot Formation Neutrophil degranulation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Colorectal or endometrial cancer ( 26621817) Metabolite levels ( 23823483) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		3 interacting genes: AGT OGT VDR
Entrez ID		5547
HPRD ID		08352
Ensembl ID		ENSG00000137509
Uniprot IDs		B7Z7Q6 P42785
PDB IDs		3N2Z
Enriched GO Terms of Interacting Partners?		Regulation Of Lipid Metabolic Process Regulation Of Membrane Hyperpolarization Regulation Of Cell Junction Assembly Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Angiotensin-activated Signaling Pathway Intracellular Signal Transduction Type 1 Angiotensin Receptor Binding Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Gene Expression Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Signaling Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Positive Regulation Of RNA Metabolic Process Renin-angiotensin Regulation Of Aldosterone Production Positive Regulation Of Intracellular Signal Transduction Regulation Of Small Molecule Metabolic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Developmental Process Regulation Of Blood Volume By Renin-angiotensin Positive Regulation Of Gap Junction Assembly Positive Regulation Of Membrane Hyperpolarization Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Lipid Metabolic Process Response To Muscle Activity Involved In Regulation Of Muscle Adaptation G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Regulation Of Renal Output By Angiotensin Response To Peptide Hormone Positive Regulation Of DNA-templated Transcription Type 2 Angiotensin Receptor Binding Negative Regulation Of Transmembrane Transport Negative Regulation Of Phosphate Transmembrane Transport Calcitriol Binding Nuclear Receptor-mediated Bile Acid Signaling Pathway Apoptotic Process Involved In Mammary Gland Involution Vitamin D Response Element Binding Positive Regulation Of Apoptotic Process Involved In Morphogenesis Bile Acid Nuclear Receptor Activity Positive Regulation Of Vitamin D Receptor Signaling Pathway Response To Bile Acid Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Vitamin D Binding Mammary Gland Branching Involved In Pregnancy Vitamin D Receptor Signaling Pathway Lithocholic Acid Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein N-acetylglucosaminyltransferase Complex Non-canonical Inflammasome Complex Assembly
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