PRCP and AGT

Number of citations of the paper that reports this interaction (PubMedID 28321)
0

Data Source:
HPRD (in vitro)

		PRCP	AGT
Description		prolylcarboxypeptidase	angiotensinogen
Image
GO Annotations	Cellular Component	Extracellular Region Lysosome Plasma Membrane Azurophil Granule Membrane Basal Part Of Cell Extracellular Exosome Ficolin-1-rich Granule Membrane	Extracellular Region Extracellular Space Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Carboxypeptidase Activity Metallocarboxypeptidase Activity Serine-type Carboxypeptidase Activity Protein Binding Peptidase Activity Dipeptidyl-peptidase Activity Hydrolase Activity Serine-type Exopeptidase Activity	Serine-type Endopeptidase Inhibitor Activity Hormone Activity Protein Binding Growth Factor Activity Superoxide-generating NADPH Oxidase Activator Activity Sodium Channel Regulator Activity Type 1 Angiotensin Receptor Binding Type 2 Angiotensin Receptor Binding Receptor Ligand Activity
	Biological Process	Angiotensin Maturation Regulation Of Thyroid Hormone Receptor Signaling Pathway Plasma Kallikrein-kinin Cascade Negative Regulation Of Systemic Arterial Blood Pressure Proteolysis Glucose Homeostasis Regulation Of Blood Vessel Endothelial Cell Migration Angiogenesis Involved In Wound Healing Energy Homeostasis Regulation Of Reactive Oxygen Species Metabolic Process	Regulation Of Cell Growth Positive Regulation Of Cytokine Production Kidney Development Blood Vessel Remodeling Regulation Of Blood Volume By Renin-angiotensin Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Renal Output By Angiotensin Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Renal System Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Regulation Of Blood Pressure Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Macrophage Derived Foam Cell Differentiation Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Regulation Of Vasoconstriction Positive Regulation Of Superoxide Anion Generation Low-density Lipoprotein Particle Remodeling Regulation Of Renal Sodium Excretion Nitric Oxide-cGMP-mediated Signaling Angiotensin-activated Signaling Pathway Regulation Of Cell Population Proliferation Vasoconstriction Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAP Kinase Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Inflammatory Response Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Renal Sodium Ion Absorption Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Cholesterol Metabolic Process Blood Vessel Diameter Maintenance Positive Regulation Of Angiotensin-activated Signaling Pathway Regulation Of Extracellular Matrix Assembly Positive Regulation Of Extracellular Matrix Assembly Negative Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Membrane Hyperpolarization Positive Regulation Of MiRNA Transcription Positive Regulation Of Gap Junction Assembly Regulation Of Cardiac Conduction Response To Angiotensin Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Intrinsic Pathway of Fibrin Clot Formation Neutrophil degranulation	PPARA activates gene expression Metabolism of Angiotensinogen to Angiotensins Metabolism of Angiotensinogen to Angiotensins Peptide ligand-binding receptors Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs			Zinc Copper Sparsentan Zinc acetate
Diseases			Renal tubular dysgenesis
GWAS		Blood protein levels ( 30072576) Colorectal or endometrial cancer ( 26621817) Metabolite levels ( 23823483) Urate levels (BMI interaction) ( 25811787)	Blood protein levels ( 30072576) Coronary artery disease ( 33020668 29212778) Diastolic blood pressure ( 27618452 28739976 27841878) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Mean arterial pressure ( 27618448) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Pancreatic ductal adenocarcinoma ( 30541042) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Systolic blood pressure ( 27841878 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		3 interacting genes: AGT OGT VDR	24 interacting genes: ACE2 AGTR1 AGTR2 ATP6AP2 CMA1 CTSG DNPEP ECE1 ENPEP EWSR1 GRB2 GSDMB HSP90AA1 ITSN2 KNG1 LNPEP MAS1 MEP1A MME PRCP PREP PRG2 REN TP53
Entrez ID		5547	183
HPRD ID		08352	00106
Ensembl ID		ENSG00000137509	ENSG00000135744
Uniprot IDs		B7Z7Q6 P42785	A0A7P0T8D1 B0ZBE2 B2R5S1 P01019
PDB IDs		3N2Z	1N9U 1N9V 2JP8 2WXW 2X0B 3CK0 3WOO 3WOR 4AA1 4APH 4FYS 5E2Q 5M3X 5M3Y 5XJM 6I3F 6I3I 6JOD 6OS0 7C6A
Enriched GO Terms of Interacting Partners?		Regulation Of Lipid Metabolic Process Regulation Of Membrane Hyperpolarization Regulation Of Cell Junction Assembly Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Angiotensin-activated Signaling Pathway Intracellular Signal Transduction Type 1 Angiotensin Receptor Binding Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Cell Communication Positive Regulation Of Gene Expression Regulation Of Angiotensin-activated Signaling Pathway Positive Regulation Of Signaling Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Positive Regulation Of RNA Metabolic Process Renin-angiotensin Regulation Of Aldosterone Production Positive Regulation Of Intracellular Signal Transduction Regulation Of Small Molecule Metabolic Process Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Developmental Process Regulation Of Blood Volume By Renin-angiotensin Positive Regulation Of Gap Junction Assembly Positive Regulation Of Membrane Hyperpolarization Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Lipid Metabolic Process Response To Muscle Activity Involved In Regulation Of Muscle Adaptation G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Regulation Of Renal Output By Angiotensin Response To Peptide Hormone Positive Regulation Of DNA-templated Transcription Type 2 Angiotensin Receptor Binding Negative Regulation Of Transmembrane Transport Negative Regulation Of Phosphate Transmembrane Transport Calcitriol Binding Nuclear Receptor-mediated Bile Acid Signaling Pathway Apoptotic Process Involved In Mammary Gland Involution Vitamin D Response Element Binding Positive Regulation Of Apoptotic Process Involved In Morphogenesis Bile Acid Nuclear Receptor Activity Positive Regulation Of Vitamin D Receptor Signaling Pathway Response To Bile Acid Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Vitamin D Binding Mammary Gland Branching Involved In Pregnancy Vitamin D Receptor Signaling Pathway Lithocholic Acid Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein N-acetylglucosaminyltransferase Complex Non-canonical Inflammasome Complex Assembly	Angiotensin Maturation Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Protein Processing Hormone Metabolic Process Protein Maturation Peptidase Activity Regulation Of Blood Pressure Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of Hormone Levels Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Biological Quality Regulation Of Systemic Arterial Blood Pressure Peptide Metabolic Process Metallopeptidase Activity Proteolysis Blood Vessel Diameter Maintenance Regulation Of Tube Size Peptide Catabolic Process Angiotensin Type II Receptor Activity Angiotensin-activated Signaling Pathway Neuropeptide Catabolic Process Hydrolase Activity Metallocarboxypeptidase Activity Vascular Process In Circulatory System Plasma Membrane Endopeptidase Activity Circulatory System Process Extracellular Exosome Regulation Of Multicellular Organismal Process Regulation Of Reactive Oxygen Species Metabolic Process Angiotensin-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Oligopeptidase Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Systemic Arterial Blood Pressure Phospholipase C-activating Angiotensin-activated Signaling Pathway Renin-angiotensin Regulation Of Aldosterone Production Substance P Catabolic Process Protein Metabolic Process Peptide Binding Aminopeptidase Activity System Process Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Blood Circulation Regulation Of Blood Volume By Renin-angiotensin Negative Regulation Of Blood Pressure Bradykinin Catabolic Process Extracellular Region Vasodilation Positive Regulation Of Cardiac Muscle Contraction
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