FANCD2 and BRIP1

Number of citations of the paper that reports this interaction (PubMedID 31180492)
58

Data Source:
BioGRID (pull down, affinity chromatography technology)

		FANCD2	BRIP1
Description		FA complementation group D2	BRCA1 interacting DNA helicase 1
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GO Annotations	Cellular Component	Chromatin Condensed Chromosome Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Body DNA Repair Complex	Nucleus Nucleoplasm Replication Fork Cytoplasm Nuclear Membrane BRCA1-B Complex
	Molecular Function	Protein Binding DNA Polymerase Binding	Nucleotide Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity Hydrolase Activity, Acting On Acid Anhydrides, In Phosphorus-containing Anhydrides Isomerase Activity ATP Hydrolysis Activity 5'-3' DNA Helicase Activity Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding Catalytic Activity, Acting On A Nucleic Acid
	Biological Process	DNA Repair DNA Damage Response Homologous Chromosome Pairing At Meiosis Gamete Generation Response To Gamma Radiation Mitotic Intra-S DNA Damage Checkpoint Signaling Cellular Response To Oxidative Stress Interstrand Cross-link Repair Regulation Of Regulatory T Cell Differentiation Brain Morphogenesis Regulation Of Inflammatory Response Neuronal Stem Cell Population Maintenance Double-strand Break Repair Involved In Meiotic Recombination Regulation Of CD40 Signaling Pathway	DNA Damage Checkpoint Signaling Nucleobase-containing Compound Metabolic Process DNA Repair Nucleotide-excision Repair Double-strand Break Repair Regulation Of Transcription By RNA Polymerase II DNA Damage Response Homologous Chromosome Pairing At Meiosis Spermatogenesis Spermatogonial Cell Division Spermatid Development Male Gonad Development Meiotic DNA Double-strand Break Processing Involved In Reciprocal Meiotic Recombination Homologous Recombination Interstrand Cross-link Repair Chiasma Assembly Seminiferous Tubule Development Protein-DNA Covalent Cross-linking Repair Double-strand Break Repair Involved In Meiotic Recombination
Pathways		Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes	Cytosolic iron-sulfur cluster assembly HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs
Diseases		Fanconi anemia	Fanconi anemia
GWAS		Alzheimer's disease ( 24755620) Waist-to-hip ratio adjusted for BMI ( 28552196)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Ovarian cancer ( 21964575) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		30 interacting genes: ATM ATR BLM BRCA1 BRCA2 BRIP1 FANCC FANCE FANCI FANCL H2AC4 H2BC3 H3C1 H4C1 MEN1 MRE11 NBN PCNA RAD51 TERF1 TNFRSF1A TNFRSF1B TNKS UBB UBE2T UHRF1 UHRF2 USP1 USP2 USP7	10 interacting genes: BLM BRCA1 CREBBP FANCD2 HDAC3 HNRNPC HSD17B14 RPA1 SIRT1 TOPBP1
Entrez ID		2177	83990
HPRD ID		01968	05797
Ensembl ID		ENSG00000144554	ENSG00000136492
Uniprot IDs		A0A6Q8PFY3 Q9BXW9	A0A804HJU1 A0A804HL36 J3QKX0 Q9BX63
PDB IDs		6VAA 6VAD 6VAE 6VAF 7AY1 7KZQ 7KZR 7KZS 7KZT 7KZV 7ZF1 8A9J 8A9K	1T15 1T29 3AL3
Enriched GO Terms of Interacting Partners?		DNA Damage Response DNA Repair DNA Metabolic Process Chromosome, Telomeric Region Chromosome Telomere Organization Cellular Response To Stress Nucleoplasm Telomere Maintenance Nucleic Acid Metabolic Process Chromosome Organization Homologous Recombination Interstrand Cross-link Repair Chromatin Remodeling Chromatin Organization Double-strand Break Repair Replication Fork Nucleobase-containing Compound Metabolic Process Regulation Of DNA Metabolic Process DNA Strand Resection Involved In Replication Fork Processing Macromolecule Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleus Signal Transduction In Response To DNA Damage DNA Recombination Negative Regulation Of Cell Cycle DNA Damage Checkpoint Signaling Mitotic G2/M Transition Checkpoint DNA Double-strand Break Processing Regulation Of Cell Cycle Regulation Of Telomere Maintenance Negative Regulation Of Cell Cycle Process DNA Binding Response To Stress Positive Regulation Of DNA Metabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Radiation Negative Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To Ionizing Radiation Positive Regulation Of Telomere Maintenance Negative Regulation Of DNA Metabolic Process Mitotic G2 DNA Damage Checkpoint Signaling Response To Ionizing Radiation Regulation Of DNA Repair Post-translational Protein Modification DNA Repair Complex Regulation Of Telomere Capping Regulation Of DNA Biosynthetic Process Lateral Element	Recombinational Repair Double-strand Break Repair Double-strand Break Repair Via Homologous Recombination DNA Repair Response To Ionizing Radiation Male Germ Cell Nucleus Lateral Element Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling P53 Binding DNA Metabolic Process Response To Radiation DNA Recombination DNA Damage Response DNA Damage Checkpoint Signaling Regulation Of Mitotic Cell Cycle PML Body Chromatin Organization Negative Regulation Of Cell Cycle Process Mitotic G2 DNA Damage Checkpoint Signaling Condensed Chromosome BRCA1-B Complex Nucleic Acid Metabolic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Cell Cycle Condensed Nuclear Chromosome Cellular Response To Radiation Cellular Response To Stress Mitotic G2/M Transition Checkpoint Nucleoplasm Damaged DNA Binding Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Phase Transition Cellular Response To Ionizing Radiation Deacetylase Activity Regulation Of DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Random Inactivation Of X Chromosome Peptidyl-lysine Acetylation Protein Deacetylation Protein Lysine Deacetylase Activity DNA Repair Complex Regulation Of Cellular Response To Heat Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin-protein Adaptor Activity Histone Deacetylase Activity Regulation Of Cell Cycle
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