FANCD2 and UBE2T

Number of citations of the paper that reports this interaction (PubMedID 26046368)
25

Data Source:
BioGRID (enzymatic study)

		FANCD2	UBE2T
Description		FA complementation group D2	ubiquitin conjugating enzyme E2 T
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GO Annotations	Cellular Component	Chromatin Condensed Chromosome Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Body DNA Repair Complex	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Protein Binding DNA Polymerase Binding	Nucleotide Binding Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	DNA Repair DNA Damage Response Homologous Chromosome Pairing At Meiosis Gamete Generation Response To Gamma Radiation Mitotic Intra-S DNA Damage Checkpoint Signaling Cellular Response To Oxidative Stress Interstrand Cross-link Repair Regulation Of Regulatory T Cell Differentiation Brain Morphogenesis Regulation Of Inflammatory Response Neuronal Stem Cell Population Maintenance Double-strand Break Repair Involved In Meiotic Recombination Regulation Of CD40 Signaling Pathway	Protein Polyubiquitination DNA Repair Protein Monoubiquitination DNA Damage Response Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination
Pathways		Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes	Fanconi Anemia Pathway Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Drugs
Diseases		Fanconi anemia
GWAS		Alzheimer's disease ( 24755620) Waist-to-hip ratio adjusted for BMI ( 28552196)	Breast cancer ( 23535733) Celiac disease ( 23936387)
Interacting Genes		30 interacting genes: ATM ATR BLM BRCA1 BRCA2 BRIP1 FANCC FANCE FANCI FANCL H2AC4 H2BC3 H3C1 H4C1 MEN1 MRE11 NBN PCNA RAD51 TERF1 TNFRSF1A TNFRSF1B TNKS UBB UBE2T UHRF1 UHRF2 USP1 USP2 USP7	25 interacting genes: AMFR ARIH2 BRCA1 CDK2 CHEK1 FANCD2 FANCL LNX2 MARCHF5 MGRN1 PCGF2 PRKCG PRKN RNF128 RNF144B RNF167 RNF31 RNF4 ROCK1 RPS6KA1 TRIM27 UBA1 UBA6 UBC ZNRF2
Entrez ID		2177	29089
HPRD ID		01968	13704
Ensembl ID		ENSG00000144554	ENSG00000077152
Uniprot IDs		A0A6Q8PFY3 Q9BXW9	Q9NPD8
PDB IDs		6VAA 6VAD 6VAE 6VAF 7AY1 7KZQ 7KZR 7KZS 7KZT 7KZV 7ZF1 8A9J 8A9K	1YH2 4CCG 5NGZ 5OJJ 6R75 7KZR 7KZS 7KZT 7KZV 8JUC 8JVD 8JVE 8JVL
Enriched GO Terms of Interacting Partners?		DNA Damage Response DNA Repair DNA Metabolic Process Chromosome, Telomeric Region Chromosome Telomere Organization Cellular Response To Stress Nucleoplasm Telomere Maintenance Nucleic Acid Metabolic Process Chromosome Organization Homologous Recombination Interstrand Cross-link Repair Chromatin Remodeling Chromatin Organization Double-strand Break Repair Replication Fork Nucleobase-containing Compound Metabolic Process Regulation Of DNA Metabolic Process DNA Strand Resection Involved In Replication Fork Processing Macromolecule Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Nucleus Signal Transduction In Response To DNA Damage DNA Recombination Negative Regulation Of Cell Cycle DNA Damage Checkpoint Signaling Mitotic G2/M Transition Checkpoint DNA Double-strand Break Processing Regulation Of Cell Cycle Regulation Of Telomere Maintenance Negative Regulation Of Cell Cycle Process DNA Binding Response To Stress Positive Regulation Of DNA Metabolic Process Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Radiation Negative Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To Ionizing Radiation Positive Regulation Of Telomere Maintenance Negative Regulation Of DNA Metabolic Process Mitotic G2 DNA Damage Checkpoint Signaling Response To Ionizing Radiation Regulation Of DNA Repair Post-translational Protein Modification DNA Repair Complex Regulation Of Telomere Capping Regulation Of DNA Biosynthetic Process Lateral Element	Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Ubiquitin Protein Ligase Activity Ubiquitin-protein Transferase Activity Transferase Activity Protein Polyubiquitination Protein Metabolic Process Zinc Ion Binding Metal Ion Binding Modification-dependent Protein Catabolic Process Macromolecule Metabolic Process Proteolysis Involved In Protein Catabolic Process Protein K63-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Ubiquitin Ligase Complex Protein Autoubiquitination Protein K6-linked Ubiquitination Macromolecule Catabolic Process Proteolysis Response To Stress Cellular Response To Stress Protein K27-linked Ubiquitination Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Cytosol Ubiquitin Activating Enzyme Activity DNA Damage Response DNA Damage Checkpoint Signaling Ubiquitin Conjugating Enzyme Binding Condensed Chromosome Negative Regulation Of Programmed Cell Death Regulation Of Organelle Organization Catabolic Process Regulation Of Protein Targeting To Mitochondrion Ubiquitin Protein Ligase Binding Signal Transduction In Response To DNA Damage Protein Monoubiquitination Cytoplasm Ubiquitin-like Modifier Activating Enzyme Activity Negative Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of Autophagy Negative Regulation Of Cell Cycle Protein Serine Kinase Activity Protein K29-linked Ubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling
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