VPS51 and NUDT3

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		VPS51	NUDT3
Gene Name		vacuolar protein sorting 51 homolog (S. cerevisiae)	nudix (nucleoside diphosphate linked moiety X)-type motif 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	GARP Complex Golgi Apparatus Integral Component Of Membrane	Cytosol Extracellular Vesicular Exosome
	Molecular Function	Molecular_function Protein Binding	Magnesium Ion Binding Diphosphoinositol-polyphosphate Diphosphatase Activity Inositol Diphosphate Tetrakisphosphate Diphosphatase Activity Inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate Diphosphatase Activity Inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate Diphosphatase Activity Inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate Diphosphatase Activity Inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase Activity Inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity Inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase Activity
	Biological Process	Lipid Transport Autophagy Protein Transport Retrograde Transport, Endosome To Golgi	Cell-cell Signaling Diadenosine Polyphosphate Catabolic Process Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Diphosphoinositol Polyphosphate Catabolic Process
Pathways			Synthesis of pyrophosphates in the cytosol Inositol phosphate metabolism
Drugs
Diseases
GWAS			Body mass index ( 20935630) Height ( 19893584)
Protein-Protein Interactions		7 interactors: CDKN1A GSK3B NUDT3 VPS52 VPS53 VPS54 YTHDC1	36 interactors: ALAS1 APEX1 ARL6IP1 ASB13 CCL11 CHCHD3 DBN1 DDR1 DNAJA1 EEF1G FXYD3 HES1 ITFG1 MAF1 MCM5 MEX3B NR2C1 NUDT5 OAT PDCD5 PEX5 PRKD3 RAB17 REEP5 RNF126 RPL17 RPL8 RPLP1 SOX30 TNNT3 TUBA1A TUBGCP4 UBR1 VPS51 WDR74 XPNPEP1
Entrez ID		738	11165
HPRD ID		12605	14849
Ensembl ID		ENSG00000149823
Uniprot IDs		Q9UID3	O95989
PDB IDs			2FVV 2Q9P
Enriched GO Terms of Interacting Partners?		Cellular Response To Heat Retrograde Transport, Endosome To Golgi Diphosphoinositol Polyphosphate Catabolic Process Diadenosine Polyphosphate Catabolic Process Protein Transport Establishment Of Protein Localization Response To Heat Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Embryonic Ectodermal Digestive Tract Development Negative Regulation Of Protein Serine/threonine Kinase Activity Phosphatidylinositol-mediated Signaling Digestive Tract Development Digestive System Development Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Protein Import Into Nucleus Hypermethylation Of CpG Island Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Protein Localization Cellular Response To Fibroblast Growth Factor Stimulus Response To Temperature Stimulus Response To Fibroblast Growth Factor Cellular Response To Interleukin-3 Intestinal Epithelial Cell Maturation Regulation Of Protein Localization To Nucleus Endosomal Transport Regulation Of Nucleocytoplasmic Transport Neurotrophin TRK Receptor Signaling Pathway Ectodermal Cell Differentiation Negative Regulation Of Protein Kinase Activity Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Neuron Maturation Negative Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Kinase Activity Cellular Response To UV-B Golgi To Vacuole Transport Protein Localization To Microtubule Negative Regulation Of Dendrite Morphogenesis Regulation Of Intracellular Protein Transport Fc Receptor Signaling Pathway Negative Regulation Of NFAT Protein Import Into Nucleus ER Overload Response Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Glycogen Biosynthetic Process Stress-induced Premature Senescence	Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Establishment Of Protein Localization To Membrane Cellular Metabolic Process Protein Targeting Intracellular Transport Protein Localization To Organelle Cellular Localization Cellular Protein Localization Translational Elongation Establishment Of Protein Localization To Organelle Catabolic Process Protein Localization To Membrane Protein Localization Intracellular Protein Transport Viral Transcription Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Cellular Process Establishment Of Localization In Cell Protein Targeting To ER Cytoplasmic Transport Aromatic Compound Catabolic Process Establishment Of Protein Localization To Endoplasmic Reticulum Protein Transport Protein Localization To Endoplasmic Reticulum DNA Strand Elongation Involved In DNA Replication Establishment Of Protein Localization Branching Involved In Mammary Gland Duct Morphogenesis DNA Strand Elongation Translational Termination Membrane Organization Cellular Macromolecule Catabolic Process Nuclear-transcribed MRNA Catabolic Process Metabolic Process MRNA Catabolic Process Transcription Factor TFIIIB Complex Assembly Negative Regulation Of Stomach Neuroendocrine Cell Differentiation Negative Regulation Of Pancreatic A Cell Differentiation Cytoplasm-associated Proteasomal Ubiquitin-dependent Protein Catabolic Process Pharyngeal Arch Artery Morphogenesis Lateral Inhibition Positive Regulation Of Protein Import Into Mitochondrial Outer Membrane Negative Regulation Of Chaperone-mediated Protein Folding Mammary Gland Duct Morphogenesis RNA Catabolic Process Cellular Nitrogen Compound Metabolic Process Response To Interleukin-4 Cellular Protein Complex Disassembly Viral Life Cycle
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