UPK1B and CD80

Data Source: HiPPIP (Novel)

		UPK1B	CD80
Name		uroplakin 1B	CD80 molecule
Structure		No pdb structure
GO Annotations	Cellular Component	Membrane Apical Plasma Membrane Extracellular Exosome Apical Plasma Membrane Urothelial Plaque	Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Protein Complex Involved In Cell Adhesion
	Molecular Function	Structural Molecule Activity Protein Binding	Virus Receptor Activity Protein Binding Coreceptor Activity Receptor Ligand Activity
	Biological Process	Response To Bacterium Epithelial Cell Differentiation	Immune System Process Regulation Of Immune System Process Negative Regulation Of T Cell Mediated Immunity Immune Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction T Cell Costimulation Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interleukin-2 Production Intracellular Signal Transduction Positive Regulation Of T Cell Proliferation T Cell Activation Negative Regulation Of T Cell Proliferation Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of DNA-templated Transcription Symbiont Entry Into Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Lipopolysaccharide
Pathways		None	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway Co-inhibition by CTLA4 Interleukin-10 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs		None	Abatacept Galiximab Belatacept
GWAS		Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042 )	Asthma ( 32296059 ) Autoimmune thyroid disease ( 32581359 ) Carotid plaque burden ( 28282560 ) Celiac disease ( 20190752 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Lobular breast cancer (menopausal hormone therapy interaction) ( 24080446 ) Primary biliary cholangitis ( 21399635 28425483 28062665 26394269 23000144 ) Primary biliary cirrhosis ( 22961000 ) Systemic lupus erythematosus ( 25862617 23273568 ) Systemic sclerosis ( 31672989 ) Vitiligo ( 27723757 22561518 )
Novel Interactors		2 novel interactors: CD80 IQCB1	4 novel interactors: IQCB1 MRPL3 TRH UPK1B
Interacting Genes		59 interacting genes: BCL2L13 BEST2 BIK BNIP2 CATSPERH CD53 CD69 CD79A CERS4 CLDN7 CYB5R3 DAGLA EDAR ERGIC3 FAM209A FFAR2 FKBP7 FNDC9 GJA8 GJB1 GPR161 GPR37L1 GPX8 ISLR2 ITGB2 KASH5 KCNJ6 KIR2DL3 KLRC1 LMNA MFF MS4A4A NEMP1 PDZK1IP1 PIK3IP1 PLPP4 RHCG SAR1A SDHAF4 SHISA4 SIT1 SLC10A1 SLC10A2 SLC16A2 SLC18A1 SLC35H1 SLC39A2 SPINT1 SSMEM1 STX1A SYT9 TMEM139 TMEM237 TMEM45B TMEM54 TMEM91 TMUB2 UPK3A VSIG1	5 interacting genes: CD274 CD28 CD86 CTLA4 NGFR
Entrez ID		7348	941
HPRD ID		03853	00202
Ensembl ID		ENSG00000114638	ENSG00000121594
Uniprot IDs		O75841	A0N0P2 P33681
PDB IDs		Not available	1DR9 1I8L 7TPS 8FXW 8FXZ 8HXA
GO Terms Enriched among Interactors		Membrane Protein Binding Plasma Membrane Bile Acid:sodium Symporter Activity	T Cell Costimulation Regulation Of T Cell Proliferation Protein Complex Involved In Cell Adhesion Coreceptor Activity Regulation Of Mononuclear Cell Proliferation Negative Regulation Of T Cell Proliferation Regulation Of Leukocyte Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Activation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Positive Regulation Of T Cell Proliferation External Side Of Plasma Membrane Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Alpha-beta T Cell Activation Regulation Of T Cell Activation Negative Regulation Of T Cell Activation Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Interleukin-4 Production Regulation Of Cell-cell Adhesion Positive Regulation Of Leukocyte Proliferation Negative Regulation Of Lymphocyte Activation Regulation Of Lymphocyte Activation Regulation Of T Cell Differentiation Regulation Of Interleukin-4 Production Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Differentiation Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Interleukin-2 Production Negative Regulation Of Cell Activation Positive Regulation Of Interleukin-10 Production Regulation Of Cell Activation Positive Regulation Of Immune Response Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Cell Population Proliferation Positive Regulation Of Immunoglobulin Production Adaptive Immune Response Negative Regulation Of Cell Adhesion Regulation Of Cell Adhesion Regulation Of Interleukin-2 Production Regulation Of Interleukin-10 Production Thyrotropin-releasing Hormone Activity Regulation Of Activated CD4-positive, Alpha-beta T Cell Apoptotic Process Positive Regulation Of Activated CD8-positive, Alpha-beta T Cell Apoptotic Process