UPK1B and EDAR

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UPK1B	EDAR
Description		uroplakin 1B	ectodysplasin A receptor
Image		No pdb structure
GO Annotations	Cellular Component	Membrane Apical Plasma Membrane Extracellular Exosome Apical Plasma Membrane Urothelial Plaque	Plasma Membrane Membrane Apical Part Of Cell
	Molecular Function	Structural Molecule Activity Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity
	Biological Process	Response To Bacterium Epithelial Cell Differentiation	Hair Follicle Development Apoptotic Process Epidermis Development Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cell Differentiation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Canonical NF-kappaB Signal Transduction Pigmentation Positive Regulation Of JNK Cascade Salivary Gland Cavitation Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways			TNFs bind their physiological receptors
Drugs
Diseases			Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic
GWAS		Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042)	Beard thickness ( 26926045) Blood protein levels ( 30072576) Cleft lip with or without cleft palate (maternal periconceptional alcohol intake interaction) ( 29535761) Ear morphology ( 26105758) Ear protrusion ( 26105758) Eyebrow thickness ( 30248107) Helix rolling ( 26105758) Lobe attachment ( 26105758) Lobe attachment (rater scored) ( 29198719) Lobe size ( 26105758) lower facial morphology traits (quantitative measurement) ( 27193062) Lung function (FVC) ( 30061609) Male-pattern baldness ( 27182965) Monobrow ( 27182965) Monobrow thickness ( 26926045) Scalp hair shape ( 26926045) Straight vs curly hair ( 27487801 29895819) Thick vs thin eyebrows ( 29895819) Urinary albumin-to-creatinine ratio ( 32600054)
Interacting Genes		59 interacting genes: BCL2L13 BEST2 BIK BNIP2 CATSPERH CD53 CD69 CD79A CERS4 CLDN7 CYB5R3 DAGLA EDAR ERGIC3 FAM209A FFAR2 FKBP7 FNDC9 GJA8 GJB1 GPR161 GPR37L1 GPX8 ISLR2 ITGB2 KASH5 KCNJ6 KIR2DL3 KLRC1 LMNA MFF MS4A4A NEMP1 PDZK1IP1 PIK3IP1 PLPP4 RHCG SAR1A SDHAF4 SHISA4 SIT1 SLC10A1 SLC10A2 SLC16A2 SLC18A1 SLC35H1 SLC39A2 SPINT1 SSMEM1 STX1A SYT9 TMEM139 TMEM237 TMEM45B TMEM54 TMEM91 TMUB2 UPK3A VSIG1	8 interacting genes: EDA EDARADD MAP3K14 SGTA TRAF1 TRAF2 TRAF3 UPK1B
Entrez ID		7348	10913
HPRD ID		03853	04974
Ensembl ID		ENSG00000114638	ENSG00000135960
Uniprot IDs		O75841	Q9UNE0
PDB IDs			7X9G
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Bile Acid:sodium Symporter Activity	Tumor Necrosis Factor Receptor Binding Thioesterase Binding Tumor Necrosis Factor-mediated Signaling Pathway Signaling Adaptor Activity Regulation Of Canonical NF-kappaB Signal Transduction CD40 Receptor Complex Cytokine-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Non-canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding TORC2 Complex Disassembly Positive Regulation Of NF-kappaB Transcription Factor Activity Trachea Gland Development TRC Complex Protein Phosphatase Binding TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Response To Other Organism Ubiquitin Ligase Complex Cytoplasmic Side Of Plasma Membrane Positive Regulation Of DNA-binding Transcription Factor Activity Immune Response Apical Plasma Membrane Urothelial Plaque Death Receptor Agonist Activity BAT3 Complex Binding Sphingolipid Binding Response To External Biotic Stimulus IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Hair Follicle Placode Formation Salivary Gland Cavitation CD27 Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of ERAD Pathway Tumor Necrosis Factor Binding Tumor Necrosis Factor Receptor Superfamily Binding Toll Signaling Pathway Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction CD40 Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Interleukin-17-mediated Signaling Pathway Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane TRIF-dependent Toll-like Receptor Signaling Pathway Identical Protein Binding Positive Regulation Of JUN Kinase Activity Ubiquitin-protein Transferase Activity Immune System Process
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