UPK1B and KLRC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UPK1B	KLRC1
Description		uroplakin 1B	killer cell lectin like receptor C1
Image		No pdb structure
GO Annotations	Cellular Component	Membrane Apical Plasma Membrane Extracellular Exosome Apical Plasma Membrane Urothelial Plaque	Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex
	Molecular Function	Structural Molecule Activity Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding Carbohydrate Binding MHC Class Ib Receptor Activity Inhibitory MHC Class Ib Receptor Activity HLA-E Specific Inhibitory MHC Class Ib Receptor Activity Protein Antigen Binding
	Biological Process	Response To Bacterium Epithelial Cell Differentiation	Negative Regulation Of T Cell Mediated Cytotoxicity Stimulatory C-type Lectin Receptor Signaling Pathway Adaptive Immune Response CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Natural Killer Cell Inhibitory Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Natural Killer Cell Activation Regulation Of Natural Killer Cell Mediated Cytotoxicity Innate Immune Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042)	Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Granulocyte percentage of myeloid white cells ( 27863252) High light scatter reticulocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Reticulocyte count ( 32888494)
Interacting Genes		59 interacting genes: BCL2L13 BEST2 BIK BNIP2 CATSPERH CD53 CD69 CD79A CERS4 CLDN7 CYB5R3 DAGLA EDAR ERGIC3 FAM209A FFAR2 FKBP7 FNDC9 GJA8 GJB1 GPR161 GPR37L1 GPX8 ISLR2 ITGB2 KASH5 KCNJ6 KIR2DL3 KLRC1 LMNA MFF MS4A4A NEMP1 PDZK1IP1 PIK3IP1 PLPP4 RHCG SAR1A SDHAF4 SHISA4 SIT1 SLC10A1 SLC10A2 SLC16A2 SLC18A1 SLC35H1 SLC39A2 SPINT1 SSMEM1 STX1A SYT9 TMEM139 TMEM237 TMEM45B TMEM54 TMEM91 TMUB2 UPK3A VSIG1	46 interacting genes: AKT1 ATP6V0B ATP6V0C BMP10 BRICD5 C3orf52 CATSPERH CD151 CD82 CGRRF1 CLDN11 CLEC2D CLEC7A CLRN2 CTXN3 CXCL14 CYB561A3 EMP1 EMP3 ERMP1 GJB2 GJB4 GJB6 GPR61 HLA-E KLRD1 KLRG1 LSMEM2 MAL MALL MS4A13 NKG7 PLP1 PMP22 PTPN11 PTPN6 SFTPC TMEM182 TMEM54 TMPPE TSPO2 UNC93B1 UPK1B VAMP5 VTI1B ZFPL1
Entrez ID		7348	3821
HPRD ID		03853	01192
Ensembl ID		ENSG00000114638	ENSG00000134545
Uniprot IDs		O75841	P26715
PDB IDs			2RMX 2YU7 3BDW 3CDG 3CII
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Bile Acid:sodium Symporter Activity	Membrane Plasma Membrane Gap Junction-mediated Intercellular Transport Bleb Assembly Intercellular Transport Structural Constituent Of Myelin Sheath Natural Killer Cell Mediated Immunity Axon Ensheathment Protein Binding Connexin Complex Gap Junction Channel Activity Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling Gap Junction Proton-transporting Two-sector ATPase Complex, Proton-transporting Domain Innate Immune Response-activating Signaling Pathway Myelination Negative Regulation Of Neutrophil Activation Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Gap Junction Assembly Positive Regulation Of Defense Response T Cell Costimulation Activation Of Innate Immune Response Golgi Lumen Acidification Vacuolar Proton-transporting V-type ATPase, V0 Domain Proton-transporting V-type ATPase, V0 Domain Lymphocyte Mediated Immunity Regulation Of Neutrophil Activation Non-membrane Spanning Protein Tyrosine Phosphatase Activity Neutrophil Activation Involved In Immune Response Central Nervous System Myelination Endosomal Lumen Acidification Leukocyte Mediated Immunity Negative Regulation Of Leukocyte Cell-cell Adhesion Defense Response To Symbiont Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Proton-transporting V-type ATPase Complex Defense Response To Other Organism Pattern Recognition Receptor Signaling Pathway Negative Regulation Of T Cell Proliferation Phagocytic Vesicle Membrane T Cell Activation Cell Communication By Electrical Coupling Regulation Of Tumor Necrosis Factor Production Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Peptidyl-tyrosine Dephosphorylation Carbohydrate Binding
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