ACTA2 and CCT4

Number of citations of the paper that reports this interaction (PMID 11580270)
13

Data Source:
HPRD (in vitro)

		ACTA2	CCT4
Gene Name		actin, alpha 2, smooth muscle, aorta	chaperonin containing TCP1, subunit 4 (delta)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Actin Cytoskeleton Smooth Muscle Contractile Fiber Protein Complex Extracellular Vesicular Exosome	Zona Pellucida Receptor Complex Nucleoplasm Cytoplasm Centrosome Cytosol Chaperonin-containing T-complex Microtubule Melanosome Cell Body Extracellular Vesicular Exosome
	Molecular Function	ATP Binding Protein Kinase Binding	Protein Binding ATP Binding Poly(A) RNA Binding Unfolded Protein Binding
	Biological Process	Muscle Contraction Regulation Of Blood Pressure Response To Virus Vascular Smooth Muscle Contraction Glomerular Mesangial Cell Development	Protein Folding Binding Of Sperm To Zona Pellucida Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Toxin Transport
Pathways		Smooth Muscle Contraction	Cargo trafficking to the periciliary membrane Protein folding Organelle biogenesis and maintenance Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Association of TriC/CCT with target proteins during biosynthesis Chaperonin-mediated protein folding Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC
Drugs
Diseases
GWAS		Immunoglobulin A ( 20694011)
Protein-Protein Interactions		16 interactors: CCT4 CCT5 CFL1 CREBBP DNASE1 EP300 GC MINK1 MYL1 MYOC PCYT1B PRKCD SHBG SNTA1 TMSB4X YBX1	10 interactors: ACTA1 ACTA2 ACTB CCNE1 CFAP52 PRPF40A RFWD2 RPS6KA1 UBC VRK2
Entrez ID		59	10575
HPRD ID		00031	05506
Ensembl ID		ENSG00000107796	ENSG00000115484
Uniprot IDs		D2JYH4 P62736	B7Z2F4 P50991
PDB IDs
Enriched GO Terms of Interacting Partners?		N-terminal Peptidyl-lysine Acetylation Regulation Of Actin Filament-based Process N-terminal Protein Amino Acid Acetylation Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein Dephosphorylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Blood Coagulation N-terminal Protein Amino Acid Modification Hemostasis Negative Regulation Of Cytoskeleton Organization Regulation Of Cellular Response To Heat Platelet Activation Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Toxin Transport Binding Of Sperm To Zona Pellucida Positive Regulation Of Dephosphorylation Regulation Of Body Fluid Levels Sperm-egg Recognition Wound Healing Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of MAPK Cascade Regulation Of DNA-templated Transcription In Response To Stress Muscle System Process 'de Novo' Posttranslational Protein Folding Actin Filament-based Process Histone H2B Acetylation Positive Regulation Of Phospholipid Scramblase Activity Skeletal Muscle Hypertrophy Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process ERBB2-ERBB3 Signaling Pathway Regulation Of Vasoconstriction By Circulating Norepinephrine Primary Spermatocyte Growth 'de Novo' Protein Folding Developmental Process Cellular Response To Heat Cell Activation Cell-cell Recognition Termination Of Signal Transduction Response To Wounding Rhythmic Process Platelet Degranulation Negative Regulation Of Actin Filament Polymerization Regulation Of Cellular Component Size Positive Regulation Of Type I Interferon Production Positive Regulation Of Phospholipid Catabolic Process Glucosylceramide Catabolic Process ERBB2 Signaling Pathway	Cell Cycle Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Regulation Of DNA-templated Transcription In Response To Stress DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Signal Transduction Involved In DNA Damage Checkpoint Toll-like Receptor 9 Signaling Pathway Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Cell Cycle TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Toll-like Receptor 4 Signaling Pathway Signal Transduction In Response To DNA Damage Immune Response-regulating Signaling Pathway Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Toll-like Receptor Signaling Pathway Skeletal Muscle Fiber Adaptation Positive Regulation Of Hepatic Stellate Cell Activation Signal Transduction By P53 Class Mediator Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Pattern Recognition Receptor Signaling Pathway Regulation Of Interleukin-1-mediated Signaling Pathway Regulation Of G1/S Transition Of Mitotic Cell Cycle Innate Immune Response-activating Signal Transduction Regulation Of Cell Cycle G1/S Phase Transition Response To Stimulus Activation Of Innate Immune Response Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Immune Response Positive Regulation Of Cellular Protein Catabolic Process DNA Damage Checkpoint Movement Of Cell Or Subcellular Component G1/S Transition Of Mitotic Cell Cycle
Tagcloud ?		attaining buffalo calves cirbp cryopreservation cryopreserved cyp11a1 d20s20 dairies dimethylsulfoxide dismutase2 dmso fbs fcc freezing germplasm homeobox leydig maturity pou pou5f1 protein3 rbm3 sod2 subfamily surviving testicular uncontrolled vim	20s assist back carry cct5 chaperonin chaperonins cryo crystallin encapsulate gammad gradients hetero homo hydrolyzed individually oligomeric oligomers organized refolding rings sedimented stain sucrose tcp testes tric ubiquitous
Tagcloud (Difference) ?		attaining buffalo calves cirbp cryopreservation cryopreserved cyp11a1 d20s20 dairies dimethylsulfoxide dismutase2 dmso fbs fcc freezing germplasm homeobox leydig maturity pou pou5f1 protein3 rbm3 sod2 subfamily surviving testicular uncontrolled vim	20s assist back carry cct5 chaperonin chaperonins cryo crystallin encapsulate gammad gradients hetero homo hydrolyzed individually oligomeric oligomers organized refolding rings sedimented stain sucrose tcp testes tric ubiquitous
Tagcloud (Intersection) ?