UBE2G1 and SYVN1

Number of citations of the paper that reports this interaction (PubMedID 14593114)
0

Data Source:
BioGRID (enzymatic study)

		UBE2G1	SYVN1
Description		ubiquitin conjugating enzyme E2 G1	synoviolin 1
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Hrd1p Ubiquitin Ligase Complex Hrd1p Ubiquitin Ligase ERAD-L Complex Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Endomembrane System Membrane Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Unfolded Protein Binding Protein-folding Chaperone Binding ATPase Binding Ubiquitin Protein Ligase Activity DNA-binding Transcription Factor Binding Ubiquitin-specific Protease Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination	Immature B Cell Differentiation Negative Regulation Of T-helper 1 Type Immune Response Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Retrograde Protein Transport, ER To Cytosol ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Stabilization Protein K48-linked Ubiquitination Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Endoplasmic Reticulum Mannose Trimming
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	XBP1(S) activates chaperone genes Hedgehog ligand biogenesis Hh mutants are degraded by ERAD ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Plasma trimethylamine N-oxide levels ( 28439531) Refractive error ( 32231278) Schizophrenia ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Small cell lung carcinoma ( 28604730)	Crohn's disease ( 32581322)
Interacting Genes		24 interacting genes: AMFR APP CBL CRBN CUL9 DIO2 FBXL2 HUWE1 ITCH MAP3K1 MARCHF6 PRKN RBCK1 RBX1 RC3H1 SMURF1 SYVN1 TRIM2 TRIM63 UBA1 UBC UBE2E1 UBE3A ZRANB1	17 interacting genes: APP ATL1 ATN1 CLU ERN1 GPR37 SLC35F2 TP53 TRIM59 UBE2D2 UBE2D3 UBE2G1 UBE2J1 UBE2U UBE2Z USP15 USP7
Entrez ID		7326	84447
HPRD ID		03340	07618
Ensembl ID		ENSG00000132388	ENSG00000162298
Uniprot IDs		P62253	Q86TM6
PDB IDs		2AWF 6D68	6A3Z 8KES 8KET 8KEV
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Modification Process Proteolysis Ubiquitin Protein Ligase Activity Protein Polyubiquitination Macromolecule Catabolic Process Protein Metabolic Process Catabolic Process Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Macromolecule Metabolic Process Protein Catabolic Process Protein Monoubiquitination Transferase Activity Ubiquitin-ubiquitin Ligase Activity Ubiquitin-specific Protease Binding Zinc Ion Binding Protein Autoubiquitination Endoplasmic Reticulum Mannose Trimming Regulation Of Signal Transduction Protein Alpha-1,2-demannosylation Metal Ion Binding Protein Deglycosylation Regulation Of Intracellular Signal Transduction Regulation Of Wnt Signaling Pathway Endoplasmic Reticulum Quality Control Compartment Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Catabolic Process ERAD Pathway Negative Regulation Of Signal Transduction Regulation Of Necroptotic Process Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Protein-folding Chaperone Binding Positive Regulation Of Protein Ubiquitination Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Programmed Necrotic Cell Death Regulation Of Post-translational Protein Modification Regulation Of Spontaneous Synaptic Transmission Positive Regulation Of Signal Transduction Positive Regulation Of Post-translational Protein Modification	Ubiquitin Conjugating Enzyme Activity Post-translational Protein Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Modification Process Protein Polyubiquitination Proteolysis Positive Regulation Of Amyloid Fibril Formation Ubiquitin Protein Ligase Binding Apoptotic Process Protein Metabolic Process Programmed Cell Death Cell Death Regulation Of Intrinsic Apoptotic Signaling Pathway Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Monoubiquitinated Protein Deubiquitination Endoplasmic Reticulum Protein-containing Complex Regulation Of Response To Endoplasmic Reticulum Stress Nucleotide Binding Transferase Activity Protein-folding Chaperone Binding Regulation Of Amyloid Fibril Formation Regulation Of Cellular Response To Stress K48-linked Deubiquitinase Activity Protein K48-linked Ubiquitination Ubiquitin-like Protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Regulation Of Amyloid-beta Clearance Modification-dependent Protein Catabolic Process Response To Stress Negative Regulation Of Signal Transduction Release Of Cytochrome C From Mitochondria ATP Binding Catabolic Process Regulation Of Signal Transduction By P53 Class Mediator Molecular Function Activator Activity Deubiquitinase Activity Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Signaling Macromolecule Metabolic Process Negative Regulation Of Cell Communication Glial Cell Proliferation Central Nervous System Development Positive Regulation Of Apoptotic Signaling Pathway Microglial Cell Activation Regulation Of Proteolysis
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